scholarly journals Molecular Epidemiology of Hepatitis B Virus in Central America Reflected in the Genetic Variability of the Small S Gene

1997 ◽  
Vol 176 (4) ◽  
pp. 851-858 ◽  
Author(s):  
Patricia Arauz‐Ruiz ◽  
Heléne Norder ◽  
Kirsten A. Visoná ◽  
Lars O. Magnius
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genetic Variability ◽  
Molecular Epidemiology ◽  
Central America ◽  
S Gene ◽  
B Virus

scholarly journals Hepatitis B Virus Pre-S Gene Deletions and Pre-S Deleted Proteins: Clinical and Molecular Implications in Hepatocellular Carcinoma

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 862
Author(s):  
Yueh-Te Lin ◽  
Long-Bin Jeng ◽  
Wen-Ling Chan ◽  
Ih-Jen Su ◽  
Chiao-Fang Teng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Mechanisms ◽  
Incidence Rates ◽  
Gene Deletions ◽  
S Gene ◽  
B Virus ◽  
Potential Applications ◽  
Prevention And Therapy

Hepatocellular carcinoma (HCC) is one of the most frequent and fatal human cancers worldwide and its development and prognosis are intimately associated with chronic infection with hepatitis B virus (HBV). The identification of genetic mutations and molecular mechanisms that mediate HBV-induced tumorigenesis therefore holds promise for the development of potential biomarkers and targets for HCC prevention and therapy. The presence of HBV pre-S gene deletions in the blood and the expression of pre-S deleted proteins in the liver tissues of patients with chronic hepatitis B and HBV-related HCC have emerged as valuable biomarkers for higher incidence rates of HCC development and a higher risk of HCC recurrence after curative surgical resection, respectively. Moreover, pre-S deleted proteins are regarded as important oncoproteins that activate multiple signaling pathways to induce DNA damage and promote growth and proliferation in hepatocytes, leading to HCC development. The signaling molecules dysregulated by pre-S deleted proteins have also been validated as potential targets for the prevention of HCC development. In this review, we summarize the clinical and molecular implications of HBV pre-S gene deletions and pre-S deleted proteins in HCC development and recurrence and highlight their potential applications in HCC prevention and therapy.

scholarly journals Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice

2018 ◽  
Vol 6 (8) ◽  
pp. 183-191
Author(s):  
Shu-Rong Xiao ◽  
Gui-Dan Xu ◽  
Wu-Jun Wei ◽  
Bin Peng ◽  
Yi-Bin Deng
Keyword(s):  
Hepatitis B Virus ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Transgenic Mice ◽  
Locked Nucleic Acid ◽  
S Gene ◽  
Antiviral Effects ◽  
B Virus

scholarly journals Genetic variability of Hepatitis B virus in Morocco

2011 ◽  
Vol 5 (S1) ◽  
Author(s):  
B Kitab ◽  
R Afifi ◽  
A Essaid El Feydi ◽  
M Benazzouz ◽  
H Salih Alj ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Genetic Variability ◽  
B Virus
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