scholarly journals Editorial Commentary: Surveillance of the Molecular Epidemiology of Hepatitis B Virus in Industrialized Countries: Necessary Despite Low Prevalence and an Available, Effective Vaccine?

2004 ◽  
Vol 39 (7) ◽  
pp. 953-954 ◽  
Author(s):  
Bernhard Zöllner
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Epidemiology ◽  
Effective Vaccine ◽  
Industrialized Countries ◽  
Editorial Commentary ◽  
B Virus ◽  
Low Prevalence

scholarly journals Állásfoglalás az egészségügyi dolgozók hepatitis B-vírus-fertőzéssel szembeni immunizációjáról

2019 ◽  
Vol 160 (41) ◽  
pp. 1607-1616
Author(s):  
Csilla Jekkel ◽  
Beáta Onozó ◽  
Petra Scharek ◽  
Andrea Kulcsár
Keyword(s):  
Health Care ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Occupational Exposures ◽  
Hbv Infection ◽  
Effective Vaccine ◽  
Care Workers ◽  
B Virus ◽  
Increasing Risk ◽  
Induced Immunity

Abstract: More than 200 million HBV surface antigen (HBsAg) positive, hepatitis B virus (HBV) carriers live worldwide. Health-care personnel have increasing risk for aquiring the HBV infection. An effective vaccine is available against the infection, however, a certain proportion of the vaccinated patients do not respond to the vaccine depending on certain factors. Therefore, vaccine-induced immunity (anti-HBs) should be tested at health-care workers. For nonresponders, there are other vaccination strategies to try to achieve protection. This recommendation also provides a guidance for postexposure prophylaxis following occupational exposures against HBV infection. This is the first Hungarian recommendation about this topic. Orv Hetil. 2019; 160(41): 1607–1616.

scholarly journals In Vitro Systems for Studying Different Genotypes/Sub-Genotypes of Hepatitis B Virus: Strengths and Limitations

Viruses ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 353 ◽  
Author(s):  
Constance N. Wose Kinge ◽  
Nimisha H. Bhoola ◽  
Anna Kramvis
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
In Vitro Model ◽  
Antiviral Agents ◽  
Model Systems ◽  
Effective Vaccine ◽  
B Virus ◽  
In Vitro Systems ◽  
Vitro Model

Hepatitis B virus (HBV) infects the liver resulting in end stage liver disease, cirrhosis, and hepatocellular carcinoma. Despite an effective vaccine, HBV poses a serious health problem globally, accounting for 257 million chronic carriers. Unique features of HBV, including its narrow virus–host range and its hepatocyte tropism, have led to major challenges in the development of suitable in vivo and in vitro model systems to recapitulate the HBV replication cycle and to test various antiviral strategies. Moreover, HBV is classified into at least nine genotypes and 35 sub-genotypes with distinct geographical distributions and prevalence, which have different natural histories of infection, clinical manifestation, and response to current antiviral agents. Here, we review various in vitro systems used to study the molecular biology of the different (sub)genotypes of HBV and their response to antiviral agents, and we discuss their strengths and limitations. Despite the advances made, no system is ideal for pan-genotypic HBV research or drug development and therefore further improvement is required. It is necessary to establish a centralized repository of HBV-related generated materials, which are readily accessible to HBV researchers, with international collaboration toward advancement and development of in vitro model systems for testing new HBV antivirals to ensure their pan-genotypic and/or customized activity.

scholarly journals Molecular epidemiology of hepatitis B virus infection in Switzerland: a retrospective cohort study

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Cédric Hirzel ◽  
Gilles Wandeler ◽  
Marta Owczarek ◽  
Meri Gorgievski-Hrisoho ◽  
Jean-Francois Dufour ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Molecular Epidemiology ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Hepatitis B Virus Infection ◽  
B Virus

Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France

1993 ◽  
Vol 18 (1) ◽  
pp. 119-122 ◽  
Author(s):  
Cyrille Féray ◽  
Michelle Gigou ◽  
Didier Samuel ◽  
Jacques Bernuau ◽  
Henri Bismuth ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Fulminant Hepatitis ◽  
Type B ◽  
Hepatitis B Virus Dna ◽  
B Virus ◽  
Low Prevalence ◽  
Hepatitis Type B

scholarly journals Molecular epidemiology of hepatitis B virus in Iran

2008 ◽  
Vol 14 (9) ◽  
pp. 858-866 ◽  
Author(s):  
S.R. Mohebbi ◽  
S. Amini-Bavil-Olyaee ◽  
N. Zali ◽  
B. Noorinayer ◽  
F. Derakhshan ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Epidemiology ◽  
B Virus

Detection of HBsAg mutants in a population with a low prevalence of hepatitis B virus infection

2007 ◽  
Vol 79 (4) ◽  
pp. 351-355 ◽  
Author(s):  
Robert Gibb ◽  
Graeme R. Nimmo ◽  
Peter O'Loughlin ◽  
Peter Lowe ◽  
David Drummond
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Low Prevalence
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