scholarly journals Markedly Elevated Levels of Interferon (IFN)‐σ, IFN‐α, Interleukin (IL)‐2, IL‐10, and Tumor Necrosis Factor‐α Associated with Fatal Ebola Virus Infection

1999 ◽  
Vol 179 (s1) ◽  
pp. S188-S191 ◽  
Author(s):  
Francois Villinger ◽  
Pierre E. Rollin ◽  
Sukhdev S. Brar ◽  
Nathaniel F. Chikkala ◽  
Jorn Winter ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Virus Infection ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Ebola Virus ◽  
Factor Α ◽  
Necrosis Factor ◽  
Ebola Virus Infection

scholarly journals Infection and Activation of Monocytes by Marburg and Ebola Viruses

2001 ◽  
Vol 75 (22) ◽  
pp. 11025-11033 ◽  
Author(s):  
Ute Ströher ◽  
Elmar West ◽  
Harald Bugany ◽  
Hans-Dieter Klenk ◽  
Hans-Joachim Schnittler ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Ebola Virus ◽  
Culture Conditions ◽  
Marburg Virus ◽  
Hemorrhagic Disease ◽  
Virus Species ◽  
Factor Α ◽  
Necrosis Factor

ABSTRACT In this study we investigated the effects of Marburg virus and Ebola virus (species Zaire and Reston) infections on freshly isolated suspended monocytes in comparison to adherent macrophages under culture conditions. Our data showed that monocytes are permissive for both filoviruses. As is the case in macrophages, infection resulted in the activation of monocytes which was largely independent of virus replication. The activation was triggered similarly by Marburg and Ebola viruses, species Zaire and Reston, as indicated by the release of the proinflammatory cytokines interleukin-1β (IL-1β), tumor necrosis factor α, and IL-6 as well as the chemokines IL-8 and gro-α. Our data suggest that infected monocytes may play an important role in the spread of filoviruses and in the pathogenesis of filoviral hemorrhagic disease.

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