Reactivation of Hepatitis B Virus Infection Associated with Anti-Tumor Necrosis Factor-α Therapy

2014 ◽  
Vol 06 (03) ◽  
Author(s):  
Lorenzo Nobili Lisa Albani
Keyword(s):  
Hepatitis B Virus ◽  
Tumor Necrosis Factor ◽  
Virus Infection ◽  
Hepatitis B ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Factor Α ◽  
Necrosis Factor

Interaction of interferon-α with interleukin-1β or tumor necrosis factor-α on hepatitis B virus enhancer activity

1992 ◽  
Vol 183 (2) ◽  
pp. 904-909 ◽  
Author(s):  
Keisuke Hamasaki ◽  
Keisuke Nakata ◽  
Kazuhiko Nakao ◽  
Satoru Mitsuoka ◽  
Takuya Tsutsumi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Tumor Necrosis Factor ◽  
Hepatitis B ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interferon Α ◽  
Enhancer Activity ◽  
B Virus ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor-α and interferon-γ inhibit synergistically viral replication in hepatitis B virus-replicating cells

1995 ◽  
Vol 47 (3) ◽  
pp. 272-277 ◽  
Author(s):  
Yuko Kawanishi ◽  
Norio Hayashi ◽  
Kazuhiro Katayama ◽  
Keiji Ueda ◽  
Tetsuo Takehara ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Tumor Necrosis Factor ◽  
Hepatitis B ◽  
Viral Replication ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interferon Γ ◽  
B Virus ◽  
Factor Α ◽  
Necrosis Factor

Use of Tumor Necrosis Factor-α-blocking Agents in Hepatitis B Virus-positive Patients: Reports of 3 Cases and Review of the Literature

2009 ◽  
Vol 36 (6) ◽  
pp. 1188-1194 ◽  
Author(s):  
STEFANIA ZINGARELLI ◽  
MICOL FRASSI ◽  
CHIARA BAZZANI ◽  
MIRKO SCARSI ◽  
MASSIMO PUOTI ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Tumor Necrosis Factor ◽  
Hepatitis B ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Viral Reactivation ◽  
Hbsag Carriers ◽  
B Virus ◽  
Factor Α ◽  
Necrosis Factor

Objective.To evaluate the development of hepatitis B virus (HBV) infection in patients receiving tumor necrosis factor-α-blocking agents (TNFBA), and to evaluate whether lamivudine (LAM) prophylaxis can reduce the risk of viral reactivation in inactive HBsAg carriers.Methods.Local experience and published reports were reviewed. Patients with HBV infection were classified as having chronic HBV hepatitis, or being inactive HBsAg carriers or occult carriers.Results.Three patients in our series and 24 patients in the literature were identified: 2 had active HBV-associated disease, 23 were inactive HBsAg carriers, and 2 occult carriers. When exposed to TNFBA, HBsAg-inactive carriers pretreated with LAM had lower risk of having detectable HBV-DNA (p = 0.02) or viral reactivation (p = 0.046) than those without LAM prophylaxis. In 3 patients who discontinued TNFBA, LAM prophylaxis was also discontinued 10–12 months thereafter without hepatitis flares. Two cases of reactivation in occult carriers (HBsAg-negative, anti-HBs+, anti-HBc+) were described in the literature.Conclusion.TNFBA should be avoided in patients with active HBV replication and should be used with caution in inactive HBsAg carriers. In these patients, the risk of viral reactivation seems to be high, but it might be reduced by prophylactic LAM, which should probably be given for a long time when TNFBA are discontinued (e.g., 12 mo). Potential occult carriers might carry a low, but not negligible, risk of viral reactivation. They should therefore be monitored with particular care.

scholarly journals The hepatitis B virus X protein up-regulates tumor necrosis factor α gene expression in hepatocytes

Hepatology ◽  
1998 ◽  
Vol 28 (4) ◽  
pp. 1013-1021 ◽  
Author(s):  
Enrique Lara-Pezzi ◽  
Pedro L. Majano ◽  
Marta Gómez-Gonzalo ◽  
Carmelo García-Monzón ◽  
Ricardo Moreno-Otero ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis B Virus ◽  
Tumor Necrosis Factor ◽  
Hepatitis B ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
X Protein ◽  
B Virus ◽  
Factor Α ◽  
Necrosis Factor
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