scholarly journals Single Nucleotide Polymorphisms in Human Genes and Increased Susceptibility to West Nile Virus Disease

2006 ◽  
Vol 193 (8) ◽  
pp. 1187-1188 ◽  
Author(s):  
Stephen J. Seligman
Keyword(s):  
West Nile Virus ◽  
Single Nucleotide Polymorphisms ◽  
Virus Disease ◽  
Nucleotide Polymorphisms ◽  
West Nile ◽  
Single Nucleotide ◽  
Human Genes ◽  
Increased Susceptibility

scholarly journals Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans

Pathogens ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 168 ◽  
Author(s):  
Aitor Nogales ◽  
Marta L. DeDiego
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Influenza A Virus ◽  
Protein Function ◽  
Influenza A ◽  
Viral Infections ◽  
Virus Disease ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Human Genes ◽  
Genomic Regions

A large number of human genes associated with viral infections contain single nucleotide polymorphisms (SNPs), which represent a genetic variation caused by the change of a single nucleotide in the DNA sequence. SNPs are located in coding or non-coding genomic regions and can affect gene expression or protein function by different mechanisms. Furthermore, they have been linked to multiple human diseases, highlighting their medical relevance. Therefore, the identification and analysis of this kind of polymorphisms in the human genome has gained high importance in the research community, and an increasing number of studies have been published during the last years. As a consequence of this exhaustive exploration, an association between the presence of some specific SNPs and the susceptibility or severity of many infectious diseases in some risk population groups has been found. In this review, we discuss the relevance of SNPs that are important to understand the pathology derived from influenza A virus (IAV) infections in humans and the susceptibility of some individuals to suffer more severe symptoms. We also discuss the importance of SNPs for IAV vaccine effectiveness.

Genetic variants associated with susceptibility of Ashkenazi Jews to West Nile virus infection

2014 ◽  
Vol 143 (4) ◽  
pp. 857-863 ◽  
Author(s):  
N. DANIAL-FARRAN ◽  
S. EGHBARIA ◽  
N. SCHWARTZ ◽  
Z. KRA-OZ ◽  
N. BISHARAT
Keyword(s):  
West Nile Virus ◽  
Genetic Variants ◽  
Disease Burden ◽  
West Nile Virus Infection ◽  
Ashkenazi Jewish ◽  
Nucleotide Polymorphisms ◽  
Ashkenazi Jews ◽  
West Nile ◽  
Single Nucleotide ◽  
Negative Controls

SUMMARYThe epidemiology of West Nile virus (WNV) in Israel is different from other neighbouring countries in the Middle East where disease burden has been minimal. We analysed a cohort of Ashkenazi Jewish patients with symptomatic WNV infection (n = 39), and WNV-negative controls (n = 61), for nine genetic variants that has been suggested to be associated with susceptibility to WNV. Two single nucleotide polymorphisms were significantly more frequent in WNV-infected than non-infected individuals, rs7280422 (MX1) [odds ratio (OR) 4·05, 95% confidence interval (CI) 2·04–8·03, P < 0·001] and rs3213545 (OASL) (OR 1·85, 95% CI 1·03–3·3, P = 0·03). Genetic polymorphism may play a significant role in susceptibility to WNV infection in Ashkenazi Jews

Characterization of single-nucleotide polymorphisms in coding regions of human genes

10.1038/10290 ◽  
1999 ◽  
Vol 22 (3) ◽  
pp. 231-238 ◽  
Author(s):  
Michele Cargill ◽  
David Altshuler ◽  
James Ireland ◽  
Pamela Sklar ◽  
Kristin Ardlie ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Coding Regions ◽  
Human Genes

scholarly journals Efficient discovery of single-nucleotide polymorphisms in coding regions of human genes

2002 ◽  
Vol 2 (4) ◽  
pp. 236-242 ◽  
Author(s):  
G Hu ◽  
B Modreck ◽  
H M F Riise Stensland ◽  
J Saarela ◽  
P Pajukanta ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Coding Regions ◽  
Human Genes
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