scholarly journals Support for the Homeobox Transcription Factor Gene ENGRAILED 2 as an Autism Spectrum Disorder Susceptibility Locus

2005 ◽  
Vol 77 (5) ◽  
pp. 851-868 ◽  
Author(s):  
Rym Benayed ◽  
Neda Gharani ◽  
Ian Rossman ◽  
Vincent Mancuso ◽  
Gloria Lazar ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Transcription Factor ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Susceptibility Locus ◽  
Transcription Factor Gene ◽  
Factor Gene ◽  
Homeobox Transcription Factor

scholarly journals Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder

2004 ◽  
Vol 9 (5) ◽  
pp. 474-484 ◽  
Author(s):  
N Gharani ◽  
R Benayed ◽  
V Mancuso ◽  
L M Brzustowicz ◽  
J H Millonig
Keyword(s):  
Autism Spectrum Disorder ◽  
Transcription Factor ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Homeobox Transcription Factor

scholarly journals Erratum: Association of the homeobox transcription factor, ENGRAILED 2, with autism spectrum disorder

2004 ◽  
Vol 9 (5) ◽  
pp. 540-540
Author(s):  
N Gharani ◽  
R Benayed ◽  
V Mancuso ◽  
L M Brzustowicz ◽  
J H Millonig
Keyword(s):  
Autism Spectrum Disorder ◽  
Transcription Factor ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Homeobox Transcription Factor

Association of the Homeobox Transcription Factor Gene ENGRAILED 2 with Autistic Disorder in Chinese Children

2008 ◽  
Vol 57 (1-2) ◽  
pp. 3-8 ◽  
Author(s):  
Pinchen Yang ◽  
For-Wey Lung ◽  
Yuh-Jyh Jong ◽  
Hsin-Yi Hsieh ◽  
Chung-Ling Liang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Autistic Disorder ◽  
Chinese Children ◽  
Transcription Factor Gene ◽  
Factor Gene ◽  
Homeobox Transcription Factor

scholarly journals Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder

PLoS Genetics ◽  
2021 ◽  
Vol 17 (2) ◽  
pp. e1009309
Author(s):  
Kunling Huang ◽  
Yuchang Wu ◽  
Junha Shin ◽  
Ye Zheng ◽  
Alireza Fotuhi Siahpirani ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Transcription Factor ◽  
Association Studies ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Genome Wide Association Studies ◽  
Transmission Disequilibrium ◽  
Fold Enrichment ◽  
Common Genetic Variants ◽  
Regulated Gene Expression

Recent advances in consortium-scale genome-wide association studies (GWAS) have highlighted the involvement of common genetic variants in autism spectrum disorder (ASD), but our understanding of their etiologic roles, especially the interplay with rare variants, is incomplete. In this work, we introduce an analytical framework to quantify the transmission disequilibrium of genetically regulated gene expression from parents to offspring. We applied this framework to conduct a transcriptome-wide association study (TWAS) on 7,805 ASD proband-parent trios, and replicated our findings using 35,740 independent samples. We identified 31 associations at the transcriptome-wide significance level. In particular, we identified POU3F2 (p = 2.1E-7), a transcription factor mainly expressed in developmental brain. Gene targets regulated by POU3F2 showed a 2.7-fold enrichment for known ASD genes (p = 2.0E-5) and a 2.7-fold enrichment for loss-of-function de novo mutations in ASD probands (p = 7.1E-5). These results provide a novel connection between rare and common variants, whereby ASD genes affected by very rare mutations are regulated by an unlinked transcription factor affected by common genetic variations.

Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome

1996 ◽  
Vol 14 (4) ◽  
pp. 392-399 ◽  
Author(s):  
Elena V. Semina ◽  
Rebecca Reiter ◽  
Nancy J. Leysens ◽  
W. Lee M. Alward ◽  
Kent W. Small ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factor Gene ◽  
Factor Gene ◽  
Rieger Syndrome ◽  
Homeobox Transcription Factor

scholarly journals Downregulation ofHlxClosely Related to the Decreased Expressions ofT-betandRunx3in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yan Xu ◽  
Jingjing Gao ◽  
Zhaoliang Su ◽  
Xiaoli Dai ◽  
Yazhen Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Associated Factors ◽  
Mrna Level ◽  
Tumor Development ◽  
Transcription Factor Gene ◽  
Factor Gene ◽  
Homeobox Transcription Factor ◽  
Pathological Event ◽  
Development Of Gastric Cancer

T-betplays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor geneHlx. Recent studies show thatT-betand Th1-associated factors are critical in regulating tumor development. However, the contributions ofHlxin the occurrence and development of cancer remain unknown. In this study, theHlx,T-bet,Runx3, and IFN-γwere measured in PBMC from patients with gastric cancer and the correlation betweenHlxandT-betor IFN-γwas assessed. The expression levels ofHlx,T-bet, andIFN-γwere significantly decreased, and there was a positive correlation betweenHlxandT-betor IFN-γ. In addition, theRunx3expression was also downregulated with the lowerT-betmRNA level. These results suggested that the decreasedHlxexpression was closely associated withT-betandRunx3downregulations and may contribute to the development of gastric cancer.

Sign in / Sign up

Export Citation Format

Share Document