scholarly journals Eagle Effect inCorynebacterium diphtheriae

2005 ◽  
Vol 191 (12) ◽  
pp. 2118-2120 ◽  
Author(s):  
Lucia Grandière‐Pérez ◽  
Cedric Jacqueline ◽  
Virginie Lemabecque ◽  
Olivier Patey ◽  
Gilles Potel ◽  
...  
Keyword(s):  
Eagle Effect

scholarly journals Eagle Effect in Nonreplicating Persister Mycobacteria

2015 ◽  
Vol 59 (12) ◽  
pp. 7786-7789 ◽  
Author(s):  
Mu-Lu Wu ◽  
Jasmie Tan ◽  
Thomas Dick
Keyword(s):  
Cell Death ◽  
Protein Synthesis ◽  
Dose Response ◽  
Mycobacterium Smegmatis ◽  
Content Type ◽  
Cell Death Pathway ◽  
Low Concentrations ◽  
Eagle Effect ◽  
Dependent Cell ◽  
Gyrase Inhibitors

ABSTRACTWe determined the microbicidal activities of antibacterials against nonreplicatingMycobacterium smegmatisgrown in a starvation-based Loebel model for persistence. Whereas most drugs lost their activity, fluoroquinolones retained lethal potency. Dose-response characterizations showed a paradoxical more-drug-kills-less Eagle effect. Pretreatment of cultures with chloramphenicol blocked the lethal action of the gyrase inhibitors. These results suggest that fluoroquinolones at low concentrations trigger a protein synthesis-dependent cell death pathway and shut off this suicide pathway at elevated concentrations.

The Eagle Effect and Antibiotic-Induced Persistence: Two Sides of the Same Coin?

2019 ◽  
Vol 27 (4) ◽  
pp. 339-354 ◽  
Author(s):  
Anggia Prasetyoputri ◽  
Angie M. Jarrad ◽  
Matthew A. Cooper ◽  
Mark A.T. Blaskovich
Keyword(s):  
Eagle Effect ◽  
Two Sides

scholarly journals Antilisterial Potential of Lactic Acid Bacteria in Eliminating Listeria monocytogenes in Host and Ready-to-Eat Food Application

2021 ◽  
Vol 12 (1) ◽  
pp. 234-257
Author(s):  
Phui-Chyng Yap ◽  
Nor-Aziyah MatRahim ◽  
Sazaly AbuBakar ◽  
Hai Yen Lee
Keyword(s):  
Lactic Acid ◽  
Listeria Monocytogenes ◽  
Lactic Acid Bacteria ◽  
Vaccine Development ◽  
Antimicrobial Properties ◽  
Listeriolysin O ◽  
Gene Coding ◽  
Food Borne ◽  
Eagle Effect ◽  
Contaminated Food

Listeriosis is a severe food borne disease with a mortality rate of up to 30% caused by pathogenic Listeria monocytogenes via the production of several virulence factors including listeriolysin O (LLO), transcriptional activator (PrfA), actin (Act), internalin (Int), etc. It is a foodborne disease predominantly causing infections through consumption of contaminated food and is often associated with ready-to-eat food (RTE) and dairy products. Common medication for listeriosis such as antibiotics might cause an eagle effect and antibiotic resistance if it is overused. Therefore, exploration of the use of lactic acid bacteria (LAB) with probiotic characteristics and multiple antimicrobial properties is increasingly getting attention for their capability to treat listeriosis, vaccine development, and hurdle technologies. The antilisterial gene, a gene coding to produce antimicrobial peptide (AMP), one of the inhibitory substances found in LAB, is one of the potential key factors in listeriosis treatment, coupled with the vast array of functions and strategies; this review summarizes the various strategies by LAB against L. monocytogenes and the prospect in development of a ‘generally regarded as safe’ LAB for treatment of listeriosis.

scholarly journals Detection and Investigation of Eagle Effect Resistance to Vancomycin in Clostridium difficile With an ATP-Bioluminescence Assay

2018 ◽  
Vol 9 ◽  
Author(s):  
Angie M. Jarrad ◽  
Mark A. T. Blaskovich ◽  
Anggia Prasetyoputri ◽  
Tomislav Karoli ◽  
Karl A. Hansford ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Eagle Effect ◽  
Atp Bioluminescence ◽  
Bioluminescence Assay ◽  
Atp Bioluminescence Assay

High Concentration of Ampicillin and the Eagle Effect among Gram-Negative Rods

Chemotherapy ◽  
1981 ◽  
Vol 27 (5) ◽  
pp. 313-317 ◽  
Author(s):  
Karin Goldstein ◽  
Vibeke Thamdrup Rosdahl
Keyword(s):  
High Concentration ◽  
Gram Negative ◽  
Eagle Effect

The Eagle Effect Revisited: Efficacy of Clindamycin, Erythromycin, and Penicillin in the Treatment of Streptococcal Myositis

1988 ◽  
Vol 158 (1) ◽  
pp. 23-28 ◽  
Author(s):  
D. L. Stevens ◽  
A. E. Gibbons ◽  
R. Bergstrom ◽  
V. Winn
Keyword(s):  
Eagle Effect

scholarly journals Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris

2018 ◽  
Vol 62 (6) ◽  
Author(s):  
Milena Kordalewska ◽  
Annie Lee ◽  
Steven Park ◽  
Indira Berrio ◽  
Anuradha Chowdhary ◽  
...  
Keyword(s):  
Hot Spot ◽  
Antifungal Susceptibility ◽  
Antifungal Drugs ◽  
Clinical Isolates ◽  
Growth Effect ◽  
Candida Auris ◽  
Content Type ◽  
Broth Microdilution Method ◽  
Eagle Effect

ABSTRACT Candida auris has simultaneously emerged on five continents as a fungal pathogen causing nosocomial outbreaks. The challenges in the treatment of C. auris infections are the variable antifungal susceptibility profiles among clinical isolates and the development of resistance to single or multiple classes of available antifungal drugs. Here, the in vitro susceptibility to echinocandin antifungal drugs was determined and FKS1 sequencing was performed on 106 C. auris clinical isolates. Four isolates were identified to be resistant to all tested echinocandins (MIC ≥ 4 mg/liter) and harbored an S639F mutation in FKS1 hot spot region 1. All remaining isolates were FKS1 wild type (WT) and echinocandin susceptible, with micafungin being the most potent echinocandin (MIC 50 = 0.125 mg/liter). Antifungal susceptibility testing with caspofungin was challenging due to the fact that all FKS1 WT isolates exhibited an Eagle effect (also known as the paradoxical growth effect), which occurred at various intensities. To assess whether the Eagle effect resulted in pharmacodynamic resistance, 8 representative isolates were evaluated for their in vivo drug response in a murine model of invasive candidiasis. All isolates were susceptible to caspofungin at a human therapeutic dose, except for those harboring the S639F mutation. The data suggest that only isolates carrying mutations in FKS1 are echinocandin resistant and that routine in vitro testing of C. auris isolates for susceptibility to caspofungin by the broth microdilution method should be viewed cautiously or avoided.

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