scholarly journals Role of Human Neutrophil Peptide–1 as a Possible Adjunct to Antituberculosis Chemotherapy

2004 ◽  
Vol 190 (8) ◽  
pp. 1476-1480 ◽  
Author(s):  
Anjana Kalita ◽  
Indu Verma ◽  
G. K. Khuller
Keyword(s):  
Human Neutrophil ◽  
Antituberculosis Chemotherapy ◽  
Human Neutrophil Peptide

Serglycin participates in retention of α-defensin in granules during myelopoiesis

Blood ◽  
2011 ◽  
Vol 118 (16) ◽  
pp. 4440-4448 ◽  
Author(s):  
Andreas Glenthøj ◽  
Jack B. Cowland ◽  
Niels H. Heegaard ◽  
Maria T. Larsen ◽  
Niels Borregaard
Keyword(s):  
Transgenic Mouse ◽  
Cell Lines ◽  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Myeloid Cell ◽  
Human Bone ◽  
Human Neutrophils ◽  
Azurophil Granule ◽  
Human Neutrophil Peptide

AbstractThe mechanism by which proteins are targeted to neutrophil granules is largely unknown. The intracellular proteoglycan serglycin has been shown to have important functions related to storage of proteins in several types of granules. The possible role of serglycin in the localization of the α-defensin, human neutrophil peptide 1 (HNP-1), a major azurophil granule protein in human neutrophils, was investigated. Murine myeloid cells, stably transfected to express HNP-1, were capable of processing HNP-1, and HNP-1 was found to associate with serglycin in murine and human myeloid cell lines as well as in human bone marow cells. A transgenic mouse expressing HNP-1 in the myeloid compartment was crossed with mice deficient in serglycin or neutrophil elastase to investigate HNP-1 sorting and processing. Neither deficiency affected processing of HNP-1, but the ability to retain fully processed HNP-1 intracellularly was reduced in mice that lack serglycin. Human granulocyte precursors transfected with siRNA against serglycin displayed similar reduced capability to retain fully processed HNP-1, demonstrating a role of serglycin in retaining mature HNP-1 intracellularly, thus preventing potential toxic effects of extracellular HNP-1.

scholarly journals Stimulus-response coupling in the human neutrophil. The role of anion fluxes in degranulation.

1982 ◽  
Vol 257 (12) ◽  
pp. 6916-6922
Author(s):  
H M Korchak ◽  
B A Eisenstat ◽  
J E Smolen ◽  
L E Rutherford ◽  
P B Dunham ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Stimulus Response

scholarly journals Nonenzymatic Conversion of ADP-Ribosylated Arginines to Ornithine Alters the Biological Activities of Human Neutrophil Peptide-1

2014 ◽  
Vol 193 (12) ◽  
pp. 6144-6151 ◽  
Author(s):  
Linda A. Stevens ◽  
Joseph T. Barbieri ◽  
Grzegorz Piszczek ◽  
Amy N. Otuonye ◽  
Rodney L. Levine ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Biological Activities ◽  
Human Neutrophil Peptide

Role of different Ca2+ sources in the superoxide production of human neutrophil granulocytes

1999 ◽  
Vol 26 (9-10) ◽  
pp. 1092-1099 ◽  
Author(s):  
Miklós Geiszt ◽  
Júlia B Szeberényi ◽  
Krisztina Káldi ◽  
Erzsébet Ligeti
Keyword(s):  
Human Neutrophil ◽  
Superoxide Production ◽  
Neutrophil Granulocytes

scholarly journals Role of secretory events in modulating human neutrophil chemotaxis.

1978 ◽  
Vol 62 (6) ◽  
pp. 1364-1374 ◽  
Author(s):  
J I Gallin ◽  
D G Wright ◽  
E Schiffmann
Keyword(s):  
Human Neutrophil ◽  
Neutrophil Chemotaxis

scholarly journals Therapeutic Potential of Human Neutrophil Peptide 1 against Experimental Tuberculosis

2001 ◽  
Vol 45 (2) ◽  
pp. 639-640 ◽  
Author(s):  
Sudhir Sharma ◽  
Indu Verma ◽  
G. K. Khuller
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Human Neutrophil ◽  
Therapeutic Efficacy ◽  
Therapeutic Potential ◽  
Therapeutic Activity ◽  
Experimental Tuberculosis ◽  
Dose Dependent ◽  
Different Doses ◽  
Human Neutrophil Peptide

ABSTRACT The therapeutic efficacy of human neutrophil peptide 1 (HNP-1) against experimental tuberculosis in mice on the basis of numbers of CFU has been examined. Mice infected with 1.5 × 104CFU of Mycobacterium tuberculosisH37Rv and treated with different doses of HNP-1 injected subcutaneously exhibited significant clearance of bacilli from lungs, livers, and spleens. There were time- and dose-dependent decreases in the bacillary load in lungs, livers, and spleens of the HNP-1-treated animals compared to that in controls (untreated animals). These observations strongly suggest the therapeutic activity of HNP-1 against tuberculosis.

scholarly journals Role of human neutrophil peptides in the initial interaction between lung epithelial cells and CD4+lymphocytes

2007 ◽  
Vol 81 (4) ◽  
pp. 1022-1031 ◽  
Author(s):  
Rosanna Vaschetto ◽  
Jonathan Grinstein ◽  
Lorenzo Del Sorbo ◽  
Aye Aye Khine ◽  
Stefanos Voglis ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Human Neutrophil ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Initial Interaction ◽  
Cd4 Lymphocytes
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