scholarly journals Role of secretory events in modulating human neutrophil chemotaxis.

1978 ◽  
Vol 62 (6) ◽  
pp. 1364-1374 ◽  
Author(s):  
J I Gallin ◽  
D G Wright ◽  
E Schiffmann
Keyword(s):  
Human Neutrophil ◽  
Neutrophil Chemotaxis

scholarly journals Key role of proline-rich tyrosine kinase 2 in interleukin-8 (CXCL8/IL-8)-mediated human neutrophil chemotaxis

Immunology ◽  
2004 ◽  
Vol 111 (4) ◽  
pp. 407-415 ◽  
Author(s):  
Vito Di Cioccio ◽  
Raffaele Strippoli ◽  
Cinzia Bizzarri ◽  
Giulia Troiani ◽  
Maria Neve Cervellera ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Human Neutrophil ◽  
Interleukin 8 ◽  
Neutrophil Chemotaxis ◽  
Tyrosine Kinase 2

scholarly journals Stimulus-response coupling in the human neutrophil. The role of anion fluxes in degranulation.

1982 ◽  
Vol 257 (12) ◽  
pp. 6916-6922
Author(s):  
H M Korchak ◽  
B A Eisenstat ◽  
J E Smolen ◽  
L E Rutherford ◽  
P B Dunham ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Stimulus Response

scholarly journals Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment

2021 ◽  
Vol 22 (4) ◽  
pp. 1825
Author(s):  
Li Hao ◽  
Aaron J. Marshall ◽  
Lixin Liu
Keyword(s):  
Small Gtpases ◽  
Neutrophil Recruitment ◽  
Neutrophil Chemotaxis ◽  
Wild Type ◽  
Adaptor Molecule ◽  
Geranylgeranyltransferase I ◽  
And Migration ◽  
Rap1 Activation

Bam32 (B cell adaptor molecule of 32 kDa) functions in the immune responses of various leukocytes. However, the role of neutrophil Bam32 in inflammation is entirely unknown. Here, we determined the role of Bam32 in chemokine CXCL2-induced neutrophil chemotaxis in three mouse models of neutrophil recruitment. By using intravital microscopy in the mouse cremaster muscle, we found that transmigrated neutrophil number, neutrophil chemotaxis velocity, and total neutrophil chemotaxis distance were increased in Bam32−/− mice when compared with wild-type (WT) mice. In CXCL2-induced mouse peritonitis, the total emigrated neutrophils were increased in Bam32−/− mice at 2 but not 4 h. The CXCL2-induced chemotaxis distance and migration velocity of isolated Bam32−/− neutrophils in vitro were increased. We examined the activation of small GTPases Rac1, Rac2, and Rap1; the levels of phospho-Akt2 and total Akt2; and their crosstalk with Bam32 in neutrophils. The deficiency of Bam32 suppressed Rap1 activation without changing the activation of Rac1 and Rac2. The pharmacological inhibition of Rap1 by geranylgeranyltransferase I inhibitor (GGTI298) increased WT neutrophil chemotaxis. In addition, the deficiency of Bam32, as well as the inhibition of Rap1 activation, increased the levels of CXCL2-induced Akt1/2 phosphorylation at Thr308/309 in neutrophils. The inhibition of Akt by SH-5 attenuated CXCL2-induced adhesion and emigration in Bam32−/− mice. Together, our results reveal that Bam32 has a suppressive role in chemokine-induced neutrophil chemotaxis by regulating Rap1 activation and that this role of Bam32 in chemokine-induced neutrophil recruitment relies on the activation of PI3K effector Akt.

scholarly journals EFFECT OF METHYL-PREDNISOLONF. AND POLYMIXIN B-SULPHATE ON ENDOTOXIN INDUCED INHIBITION OF HUMAN NEUTROPHIL CHEMOTAXIS

1977 ◽  
Vol 11 (4) ◽  
pp. 501-501
Author(s):  
Andrew C Issekutz ◽  
Matilda Ng ◽  
W Douglas Biggar ◽  
A Sass-Kortsak
Keyword(s):  
Human Neutrophil ◽  
Neutrophil Chemotaxis

Role of different Ca2+ sources in the superoxide production of human neutrophil granulocytes

1999 ◽  
Vol 26 (9-10) ◽  
pp. 1092-1099 ◽  
Author(s):  
Miklós Geiszt ◽  
Júlia B Szeberényi ◽  
Krisztina Káldi ◽  
Erzsébet Ligeti
Keyword(s):  
Human Neutrophil ◽  
Superoxide Production ◽  
Neutrophil Granulocytes

Role of Neutrophil Chemotaxis in the Pathogenesis of Urinary Tract Infection

1987 ◽  
Vol 137 (2) ◽  
pp. 342-344 ◽  
Author(s):  
Abdul J. Khan ◽  
Kusum Kumar ◽  
Hugh E. Evans
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Neutrophil Chemotaxis

The role of neutrophil chemotaxis activity as an immunologic biomarker to predict mortality in critically-ill patients with severe sepsis

2020 ◽  
Vol 56 ◽  
pp. 215-221 ◽  
Author(s):  
Nattachai Srisawat ◽  
Win Kulvichit ◽  
Somkanya Tungsanga ◽  
Sadudee Peerapornratana ◽  
Suttinan Vorasitchai ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Neutrophil Chemotaxis
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