scholarly journals Increased Adhesion Molecule and Chemokine Receptor Expression on CD8+T Cells Trafficking to Cerebrospinal Fluid in HIV‐1 Infection

2004 ◽  
Vol 189 (12) ◽  
pp. 2202-2212 ◽  
Author(s):  
Barbara L. Shacklett ◽  
Catherine A. Cox ◽  
David T. Wilkens ◽  
R. Karl Karlsson ◽  
Annelie Nilsson ◽  
...  
Keyword(s):  
T Cells ◽  
Cerebrospinal Fluid ◽  
Adhesion Molecule ◽  
Chemokine Receptor ◽  
Cd8 T Cells ◽  
Receptor Expression ◽  
Chemokine Receptor Expression ◽  
Hiv 1

scholarly journals Fetal exposure to HIV-1 alters chemokine receptor expression by CD4+T cells and increases susceptibility to HIV-1

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Madeleine J. Bunders ◽  
John L. van Hamme ◽  
Machiel H. Jansen ◽  
Kees Boer ◽  
Neeltje A. Kootstra ◽  
...  
Keyword(s):  
T Cells ◽  
Chemokine Receptor ◽  
Cd4 T Cells ◽  
Receptor Expression ◽  
Fetal Exposure ◽  
Chemokine Receptor Expression ◽  
Hiv 1

IL-8 responsiveness defines a subset of CD8 T cells poised to kill

Blood ◽  
2004 ◽  
Vol 104 (12) ◽  
pp. 3463-3471 ◽  
Author(s):  
Christoph Hess ◽  
Terry K. Means ◽  
Patrick Autissier ◽  
Tonia Woodberry ◽  
Marcus Altfeld ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chemokine Receptor ◽  
Cd8 T Cells ◽  
Molecular Mechanisms ◽  
Cell Subset ◽  
Cd8 T Cell ◽  
Effector Memory ◽  
Immune System Activation ◽  
Hiv 1

CD8 T cells play a key role in host defense against intracellular pathogens. Efficient migration of these cells into sites of infection is therefore intimately linked to their effector function. The molecular mechanisms that control CD8 T-cell trafficking into sites of infection and inflammation are not well understood, but the chemokine/chemokine receptor system is thought to orchestrate this process. Here we systematically examined the chemokine receptor profile expressed on human CD8 T cells. Surprisingly, we found that CXC chemokine receptor 1 (CXCR1), the predominant neutrophil chemokine receptor, defined a novel interleukin-8/CXC ligand 8 (IL-8/CXCL8)–responsive CD8 T-cell subset that was enriched in perforin, granzyme B, and interferon-γ (IFNγ), and had high cytotoxic potential. CXCR1 expression was down-regulated by antigen stimulation both in vitro and in vivo, suggesting antigen-dependent shaping of the migratory characteristics of CD8 T cells. On virus-specific CD8 T cells from persons with a history of Epstein-Barr virus (EBV) and influenza infection, CXCR1 expression was restricted to terminally differentiated effector memory cells. In HIV-1 infection, CXCR1-expressing HIV-1–specific CD8 T cells were present only in persons who were able to control HIV-1 replication during structured treatment interruptions. Thus, CXCR1 identifies a subset of CD8 T cells poised for immediate cytotoxicity and early recruitment into sites of innate immune system activation.

scholarly journals Changes in Chemokine Receptor Expression of Regulatory T Cells After Ex Vivo Culture

2012 ◽  
Vol 35 (4) ◽  
pp. 329-336 ◽  
Author(s):  
Rikhia Chakraborty ◽  
Cliona Rooney ◽  
Gianpietro Dotti ◽  
Barbara Savoldo
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Chemokine Receptor ◽  
Ex Vivo ◽  
Receptor Expression ◽  
Chemokine Receptor Expression ◽  
Ex Vivo Culture

Chemokine receptor expression on T cells is related to new lesion development in multiple sclerosis

2002 ◽  
Vol 133 (1-2) ◽  
pp. 225-232 ◽  
Author(s):  
M.J Eikelenboom ◽  
J Killestein ◽  
T Izeboud ◽  
N.F Kalkers ◽  
R.A.W van Lier ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Chemokine Receptor ◽  
Receptor Expression ◽  
Lesion Development ◽  
Chemokine Receptor Expression

Circulating T Cells Derived From Patients with Low Risk Myelodysplastic Syndromes Show Altered Chemokine Receptor Expression

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4018-4018
Author(s):  
Kristoffer E Sand ◽  
Astrid Olsnes Kittang ◽  
Øystein Bruserud
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chemokine Receptor ◽  
Cd8 T Cells ◽  
Central Memory ◽  
Low Risk ◽  
Receptor Expression ◽  
Effector Memory ◽  
Circulating T Cells ◽  
Cx3cr1 Expression

Abstract Abstract 4018 Several T cell abnormalities have been described in myelodysplastic syndromes (MDS), and such abnormalities may become important for identification of patients who will benefit from T cell targeting immunosuppressive treatment. Chemokine receptor repertoires are important in the regulation of both T cell migration and function and may therefore be important in the development of MDS. Materials and Methods: The chemokine receptor expression by circulating T cells were investigated by multicolor flow cytometry for patients with newly diagnosed low risk MDS (N=16) and for healthy controls (N=18). CD3+CD8+ and CD3+CD8- cells were examined for expression of CCR2-7, CXCR3-4 and CX3CR1 (only 7 unselected patients examined for CX3CR1 expression). CCR6 and CXCR4 expression was also investigated for specific T cell subsets defined by CD62L and CD45RA expression (naïve, central memory, effector memory and terminal effector). CX3CR1 expression was stratified for CD8+ and CD8- subpopulations according to high, low and negative expression of CCR5. Results: Chemokine receptor profiles showed several differences between low risk MDS patients and controls. Total CD8+ T cells from MDS patients showed increased expression of CCR3 (p=0.005) and decreased expression of CCR7 and CCR4 (p=0.023 and p=0.036 respectively), whereas the CD8- T cells from MDS patients showed increased expression of CX3CR1 (p=0.043). In contrast, CCR6 expression was increased only by CD8+ central memory T cells (p=0.044). Finally, CD8+CCR5- and CD8-CCR5high cells from MDS patients showed increased expression of CX3CR1 compared with the controls (p=0.011 and p=0.049). Discussion: CCR7 is mainly expressed by central memory and naïve T cells whereas CX3CR1 is especially expressed by cytotoxic effector lymphocytes independent of the lymphocyte subclass (i.e. CD4, CD8, delta/gamma and NK cells). The observed changes are in line with a shift from naïve/central memory to effector/effector memory dominance, especially in the CD8+ population. A similar shift has been described previously using CD45RA and CD62L (Zou et al, Leukemia 2009). Our median values are in line with such a shift. CCR6 expression is associated with IL17 production both for CD8+ and CD4+cells, and increased levels of circulating CD4+ IL17 producing cells in low risk MDS have been described. Conclusions: The chemokine receptor profiles of circulating T cells differ between low risk MDS patients and healthy controls, especially for the CD8+ T cell subset. These differences may be important for T cell trafficking and disease development, and they may reflect a shift from naïve to effector/effector memory cell dominance in low risk MDS. Disclosures: No relevant conflicts of interest to declare.

Sign in / Sign up

Export Citation Format

Share Document