Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns

2008 ◽  
Vol 9 (3) ◽  
pp. 292-300 ◽  
Author(s):  
Eric Sebzda ◽  
Zhiying Zou ◽  
John S Lee ◽  
Tao Wang ◽  
Mark L Kahn
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
Chemokine Receptor ◽  
Expression Patterns ◽  
Receptor Expression ◽  
Naive T Cells ◽  
Chemokine Receptor Expression ◽  
Naïve T Cells

scholarly journals Changes in Chemokine Receptor Expression of Regulatory T Cells After Ex Vivo Culture

2012 ◽  
Vol 35 (4) ◽  
pp. 329-336 ◽  
Author(s):  
Rikhia Chakraborty ◽  
Cliona Rooney ◽  
Gianpietro Dotti ◽  
Barbara Savoldo
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Chemokine Receptor ◽  
Ex Vivo ◽  
Receptor Expression ◽  
Chemokine Receptor Expression ◽  
Ex Vivo Culture

Chemokine receptor expression on T cells is related to new lesion development in multiple sclerosis

2002 ◽  
Vol 133 (1-2) ◽  
pp. 225-232 ◽  
Author(s):  
M.J Eikelenboom ◽  
J Killestein ◽  
T Izeboud ◽  
N.F Kalkers ◽  
R.A.W van Lier ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Chemokine Receptor ◽  
Receptor Expression ◽  
Lesion Development ◽  
Chemokine Receptor Expression

Limited expression of R5-tropic HIV-1 in CCR5-positive type 1–polarized T cells explained by their ability to produce RANTES, MIP-1α, and MIP-1β

Blood ◽  
2000 ◽  
Vol 95 (4) ◽  
pp. 1167-1174 ◽  
Author(s):  
Francesco Annunziato ◽  
Grazia Galli ◽  
Filomena Nappi ◽  
Lorenzo Cosmi ◽  
Roberto Manetti ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Memory T Cells ◽  
Receptor Expression ◽  
Th2 Cells ◽  
Th1 Cells ◽  
Naive T Cells ◽  
Naïve T Cells ◽  
Viral Spread ◽  
Hiv 1

Human T helper (Th) cells (Th1- or Th2-oriented memory T cells as well as Th1- or Th2-polarized naive T cells) were infected in vitro with an R5-tropic HIV-1 strain (BaL) and assessed for their profile of cytokine production, CCR5 receptor expression, and HIV-1 p24 antigen (p24 Ag) production. Higher p24 Ag production was found in CCR5-negative Th2-like memory T cells than in CCR5-positive Th1-like memory T cells. By contrast, p24 Ag production was higher in Th1-polarized activated naive T cells in the first 4 days after infection. However, p24 Ag production in Th1-polarized T cells became comparable or even lower than the production in Th2-polarized populations later in infection or when the cells were infected with HIV-1BaL after secondary stimulation. The higher levels of p24 Ag production by Th1-polarized naive T cells soon after infection reflected a higher virus entry, as assessed by the single round infection assay using the HIV–chloramphenicol acetyl transferase (HIV-CAT) R5-tropic virus that contains the envelope protein of HIV-1 YU2 strain. The limitation of viral spread in the Th1-polarized populations, despite the initial higher level of T-cell entry of R5-tropic strains, was due to the ability of Th1 cells to produce greater amounts of β-chemokines than Th2 cells. In fact, an inverse correlation was observed between Th1-polarized naive T cells and Th1-like memory-activated T cells in regards to p24 Ag production and the release of the following CCR5-binding chemokines: regulated on activation normal T expressed and secreted (RANTES), macrophage inflammatory protein–1 (MIP-1), and MIP-1β. Moreover, infection with the HIV-1BaL strain of Th1-polarized T cells in the presence of a mixture of anti-RANTES, anti–MIP-1, and anti–MIP-1β neutralizing antibodies resulted in a significant increase of HIV-1 expression. These findings suggest that Th1-type responses may favor CD4+ T-cell infection by R5-tropic HIV-1 strains, but HIV-1 spread in Th1 cells is limited by their ability to produce CCR5-binding chemokines.

scholarly journals Increased Adhesion Molecule and Chemokine Receptor Expression on CD8+T Cells Trafficking to Cerebrospinal Fluid in HIV‐1 Infection

2004 ◽  
Vol 189 (12) ◽  
pp. 2202-2212 ◽  
Author(s):  
Barbara L. Shacklett ◽  
Catherine A. Cox ◽  
David T. Wilkens ◽  
R. Karl Karlsson ◽  
Annelie Nilsson ◽  
...  
Keyword(s):  
T Cells ◽  
Cerebrospinal Fluid ◽  
Adhesion Molecule ◽  
Chemokine Receptor ◽  
Cd8 T Cells ◽  
Receptor Expression ◽  
Chemokine Receptor Expression ◽  
Hiv 1
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