scholarly journals A Proof‐of‐Concept Study of Short‐Cycle Intermittent Antiretroviral Therapy with a Once‐Daily Regimen of Didanosine, Lamivudine, and Efavirenz for the Treatment of Chronic HIV Infection

2004 ◽  
Vol 189 (11) ◽  
pp. 1974-1982 ◽  
Author(s):  
Mark Dybul ◽  
Elizabeth Nies‐Kraske ◽  
Robin Dewar ◽  
Frank Maldarelli ◽  
Claire W. Hallahan ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Daily Regimen ◽  
Proof Of Concept ◽  
Once Daily ◽  
Short Cycle ◽  
Concept Study ◽  
Chronic Hiv Infection

Efficacy and Safety of a Once Daily Regimen with Efavirenz, Lamivudine, and Didanosine, with and without Food, as Initial Therapy for HIV Infection: The ELADI Study

2007 ◽  
Vol 23 (10) ◽  
pp. 1237-1241 ◽  
Author(s):  
Matilde Sánchez-Conde ◽  
Rosario Palacios ◽  
José Sanz ◽  
Sonia Rodríguez-Novoa ◽  
Pablo Rivas ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Initial Therapy ◽  
Daily Regimen ◽  
Efficacy And Safety ◽  
Once Daily

Structured Intermittent Interruption of Chronic HIV Infection Treatment with Highly Active Antiretroviral Therapy: Effects on Leptin and TNF-α

2006 ◽  
Vol 22 (4) ◽  
pp. 307-314 ◽  
Author(s):  
M. Montes De Oca Arjona ◽  
R. Pérez-Cano ◽  
R. Garcia-Juárez ◽  
A. Martín-Aspas ◽  
C. Fernández Gutiérrez Del Álamo ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Infection Treatment ◽  
Tnf Α ◽  
Chronic Hiv Infection

scholarly journals B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy

Blood ◽  
2010 ◽  
Vol 116 (25) ◽  
pp. 5571-5579 ◽  
Author(s):  
Susan Moir ◽  
Clarisa M. Buckner ◽  
Jason Ho ◽  
Wei Wang ◽  
Jenny Chen ◽  
...  
Keyword(s):  
B Cells ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
B Cell ◽  
Immune Cell ◽  
Memory B Cells ◽  
Early Initiation ◽  
Cell Counts ◽  
The Impact ◽  
Chronic Hiv Infection

Abstract Characterization of lymphocytes including B cells during early versus chronic HIV infection is important for understanding the impact of chronic viremia on immune cell function. In this setting, we investigated B cells before and after reduction of HIV plasma viremia by antiretroviral therapy (ART). At baseline, peripheral blood B-cell counts were significantly lower in both early and chronic HIV-infected individuals compared with uninfected controls. Similar to CD4+ but not CD8+ T cells, B-cell numbers in both groups increased significantly after ART. At baseline, B cells of early HIV-infected individuals were composed of a higher percentage of plasmablasts and resting memory B cells compared with chronic HIV-infected individuals whose B cells were composed of a higher percentage of immature/transitional and exhausted B cells compared with their early infection counterparts. At 1 year after ART, the percentage of resting memory B cells remained higher in early compared with chronic HIV-infected individuals. This difference translated into a better functional profile in that memory B-cell responses to HIV and non-HIV antigens were superior in early- compared with chronic-treated HIV infected individuals. These findings provide new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage.

scholarly journals Combination antiretroviral therapy and chronic HIV infection affect serum retinoid concentrations: longitudinal and cross-sectional assessments

2012 ◽  
Vol 9 (1) ◽  
pp. 3 ◽  
Author(s):  
Maude Loignon ◽  
Hélène Brodeur ◽  
Sonia Deschênes ◽  
Denis Phaneuf ◽  
Pangala V Bhat ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Combination Antiretroviral Therapy ◽  
Cross Sectional ◽  
Chronic Hiv Infection

scholarly journals Immunity to Human Immunodeficiency Virus (HIV) in Children with Chronic HIV Infection Receiving Highly Active Antiretroviral Therapy

2003 ◽  
Vol 10 (5) ◽  
pp. 821-825 ◽  
Author(s):  
Adriana Weinberg ◽  
Gregory B. Pott
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Lymphocyte Proliferation ◽  
Specific Cell ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Ifn Γ ◽  
Chronic Hiv Infection

ABSTRACT Our objective was to describe the CD4-mediated human immunodeficiency virus (HIV)-specific cell-mediated immunity (CMI) and its virologic and immunologic correlates in children with chronic HIV infection on highly active antiretroviral therapy (HAART). Twelve HIV-infected children on stable antiretroviral therapy with a median level of CD4+ lymphocytes (CD4%) of 25.5% and a median viral load (VL) of 786 HIV RNA copies/ml were enrolled in this study. Nine of these children were also cytomegalovirus (CMV) seropositive. Blood mononuclear cells, stimulated with HIV and CMV antigens, were used to measure lymphocyte proliferation and to enumerate gamma interferon (IFN-γ)-producing CD4+ cells. HIV CMI and CMV CMI were detected in similar proportions of patients and correlated with each other, although the HIV responses were less robust. HIV lymphocyte proliferation significantly increased with lower HIV VL and showed a trend to increase with higher CD4% and longer time on HAART. The in vitro IFN-γ response to HIV or CMV was not affected by CD4%, VL, or HAART. Pediatric patients with established HIV infection on HAART frequently exhibit HIV CMI despite undetectable HIV replication. We concluded that the association between HIV CMI and CMV CMI indicates that the same factors govern responsiveness to either antigen.

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