scholarly journals Selective Up‐Regulation of Matrix Metalloproteinase–9 Expression in Human Erythema Migrans Skin Lesions of Acute Lyme Disease

2003 ◽  
Vol 188 (8) ◽  
pp. 1098-1104 ◽  
Author(s):  
Zhihui Zhao ◽  
Hernan Chang ◽  
Richard P. Trevino ◽  
Kara Whren ◽  
Jag Bhawan ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Matrix Metalloproteinase ◽  
Erythema Migrans ◽  
Skin Lesions ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

scholarly journals CD14 Mediates Cross Talk between Mononuclear Cells and Fibroblasts for Upregulation of Matrix Metalloproteinase 9 by Borrelia burgdorferi

2007 ◽  
Vol 75 (6) ◽  
pp. 3062-3069 ◽  
Author(s):  
Zhihui Zhao ◽  
Rhonda Fleming ◽  
Bilaal McCloud ◽  
Mark S. Klempner
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Matrix Metalloproteinase ◽  
Mononuclear Cells ◽  
Erythema Migrans ◽  
Matrix Metalloproteinase 9 ◽  
Dependent Manner ◽  
U937 Cells ◽  
Concentration Dependent Manner ◽  
Metalloproteinase 9

ABSTRACT Lyme disease is an infection caused by a tick-borne spirochete, Borrelia burgdorferi. Matrix metalloproteinase 9 (MMP-9) was selectively upregulated in the erythema migrans skin lesions of patients with acute Lyme disease. In this study, the mechanism of upregulation of MMP-9 was investigated in vitro and in vivo. The concentrations of MMP-9 and soluble CD14 were markedly elevated in serum from patients with acute Lyme disease and were also upregulated in U937 cells by B. burgdorferi in a time- and concentration-dependent manner. MMP-9 mRNA was expressed at baseline in fibroblasts in the presence or absence of B. burgdorferi. However, when fibroblasts were incubated with supernatants from U937 cells with B. burgdorferi or recombinant CD14, the expression of MMP-9 was significantly increased. This effect was completely abolished by the anti-CD14 antibody. These data suggest that the upregulation of MMP-9 by B. burgdorferi involves the CD14 pathway in infiltrating inflammatory cells. Fibroblasts could be recruited to amplify local production of MMP-9 by acquiring CD14 from macrophages.

scholarly journals Expression of matrix metalloproteinase-9 in skin lesions of leprosy patients: the difference between paucibacillary and multibacillary cases

2020 ◽  
Vol 91 (4) ◽  
pp. 413-420
Author(s):  
Garima Singh ◽  
Aarzoo Jahan ◽  
Ruchika Gupta ◽  
Navmeet Soin ◽  
Leela Pant ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Skin Lesions ◽  
Matrix Metalloproteinase 9 ◽  
Leprosy Patients ◽  
The Difference ◽  
Metalloproteinase 9

Immunohistochemical Study of the Expression of Matrix Metalloproteinase-9 in Skin Lesions of Mycosis Fungoides

2010 ◽  
Vol 32 (2) ◽  
pp. 162-169 ◽  
Author(s):  
Hoda Rasheed ◽  
Marwa Mohsen Tolba Fawzi ◽  
Mona R E Abdel-Halim ◽  
Amal M Eissa ◽  
Nahla Mohammed Salem ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Mycosis Fungoides ◽  
Immunohistochemical Study ◽  
Skin Lesions ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

473 Adenosine stimulates matrix metalloproteinase-9 secretion by THP-1-derived macrophages

2007 ◽  
Vol 6 (1) ◽  
pp. 102-102
Author(s):  
E VELOT ◽  
I ERNENS ◽  
B HAAS ◽  
C JEANTY ◽  
D ROUY ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

Die Bedeutung der Matrix-Metalloproteinase–9 für die Leberhomöostase – Ein induzierbares transgenes Mausmodell

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
F Thieringer ◽  
E Meyer ◽  
P Czochra ◽  
U Schmitt ◽  
JF Garcia-Lazaro ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9
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