scholarly journals Thrice-Weekly Clarithromycin-Containing Regimen for Treatment of Mycobacterium kansasii Lung Disease: Results of a Preliminary Study

2003 ◽  
Vol 37 (9) ◽  
pp. 1178-1182 ◽  
Author(s):  
D. E. Griffith ◽  
B. A. Brown-Elliott ◽  
R. J. Wallace
Keyword(s):  
Lung Disease ◽  
Mycobacterium Kansasii ◽  
Preliminary Study

scholarly journals Long-term relapses after 12-month treatment for Mycobacterium kansasii lung disease

2009 ◽  
Vol 33 (1) ◽  
pp. 148-152 ◽  
Author(s):  
M. Santin ◽  
J. Dorca ◽  
F. Alcaide ◽  
L. Gonzalez ◽  
S. Casas ◽  
...  
Keyword(s):  
Lung Disease ◽  
Mycobacterium Kansasii

Clinical features of radiologically atypical Mycobacterium kansasii lung disease in Japan

2019 ◽  
Author(s):  
Yusaku Kusaba ◽  
Manabu Suzuki ◽  
Eriko Morino ◽  
Jin Takasaki ◽  
Haruhito Sugiyama
Keyword(s):  
Lung Disease ◽  
Clinical Features ◽  
Mycobacterium Kansasii ◽  
Atypical Mycobacterium

scholarly journals A Murine Model of Mycobacterium kansasii Infection Reproducing Necrotic Lung Pathology Reveals Considerable Heterogeneity in Virulence of Clinical Isolates

2021 ◽  
Vol 12 ◽  
Author(s):  
Vinicius O. Mussi ◽  
Thatiana L. B. V. Simão ◽  
Fabrício M. Almeida ◽  
Edson Machado ◽  
Luciana D. de Carvalho ◽  
...  
Keyword(s):  
Lung Disease ◽  
Pulmonary Disease ◽  
Virulent Strain ◽  
The United States ◽  
Clinical Isolates ◽  
Lung Pathology ◽  
Mycobacterium Kansasii ◽  
Considerable Heterogeneity ◽  
Highly Virulent

Among non-tuberculous mycobacteria, Mycobacterium kansasii is one of the most pathogenic, able to cause pulmonary disease indistinguishable from tuberculosis in immunocompetent susceptible adults. The lack of animal models that reproduce human-like lung disease, associated with the necrotic lung pathology, impairs studies of M. kansasii virulence and pathogenicity. In this study, we examined the ability of the C57BL/6 mice, intratracheally infected with highly virulent M. kansasii strains, to produce a chronic infection and necrotic lung pathology. As a first approach, we evaluated ten M. kansasii strains isolated from Brazilian patients with pulmonary disease and the reference strain M. kansasii ATCC 12478 for virulence-associated features in macrophages infected in vitro; five of these strains differing in virulence were selected for in vivo analysis. Highly virulent isolates induced progressive lung disease in mice, forming large encapsulated caseous granulomas in later stages (120–150 days post-infection), while the low-virulent strain was cleared from the lungs by day 40. Two strains demonstrated increased virulence, causing premature death in the infected animals. These data demonstrate that C57BL/6 mice are an excellent candidate to investigate the virulence of M. kansasii isolates. We observed considerable heterogeneity in the virulence profile of these strains, in which the presence of highly virulent strains allowed us to establish a clinically relevant animal model. Comparing public genomic data between Brazilian isolates and isolates from other geographic regions worldwide demonstrated that at least some of the highly pathogenic strains isolated in Brazil display remarkable genomic similarities with the ATCC strain 12478 isolated in the United States 70 years ago (less than 100 SNPs of difference), as well as with some recent European clinical isolates. These data suggest that few pathogenic clones have been widely spread within M. kansasii population around the world.

scholarly journals Short Communication: Subtyping ofMycobacterium kansasiiby PCR-Restriction Enzyme Analysis of thehsp65Gene

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Zofia Bakuła ◽  
Aleksandra Safianowska ◽  
Magdalena Nowacka-Mazurek ◽  
Jacek Bielecki ◽  
Tomasz Jagielski
Keyword(s):  
Lung Disease ◽  
Pulmonary Disease ◽  
Restriction Enzyme ◽  
Short Communication ◽  
Nontuberculous Mycobacteria ◽  
Enzyme Analysis ◽  
Restriction Enzyme Analysis ◽  
Mycobacterium Kansasii ◽  
Clinical Specimens ◽  
Common Causes

Mycobacterium kansasiiis one of the most common causes of pulmonary disease resulting from nontuberculous mycobacteria (NTM). It is also the most frequently isolated NTM species from clinical specimens in Poland. The aim of this study was to investigate the distribution ofM. kansasiisubtypes among patients suspected of having pulmonary NTM disease. Fifty clinical isolates ofM. kansasiirecovered from as many patients with suspected mycobacterial lung disease between 2000 and 2010 in Poland were genotyped by PCR-restriction enzyme analysis (PCR-REA) of partialhsp65gene.Mycobacterium kansasiisubtype I was the only genotype to be identified among the isolates, both disease-associated and non-disease-associated. Isolation ofM. kansasiisubtype I from clinical specimens may be indicative of infection but may also merely represent colonization.

Antituberculotic 4'-Cyclohexylthiobenzanilides: Combination of Free-Wilson Method in QSAR with Topliss Approach

1993 ◽  
Vol 58 (1) ◽  
pp. 205-212 ◽  
Author(s):  
Karel Waisser ◽  
Lenka Kubicová ◽  
Želmíra Odlerová
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Antimycobacterial Activity ◽  
Significant Activity ◽  
Mycobacterium Kansasii ◽  
Type Analysis ◽  
Qsar Analysis ◽  
Preliminary Study

On the basis of a preliminary study of antimycobacterial activity of thiobenzanilides against Mycobacterium kansasii, a group of 4'-cyclohexylthiobenzanilids have been prepared which exhibit a significant activity against the microorganism mentioned. The whole set of 35 thiobenzanilides was tested with Mycobacterium tuberculosis, and on the basis of QSAR analysis conclusions have been made with regard to prognostics of structures suitable for further studies. The problem was solved by the method by Free and Wilson combined with the Topliss approach and by a Hansch type analysis.

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