scholarly journals Virological Features and Clinical Manifestations Associated with Human Metapneumovirus: A New Paramyxovirus Responsible for Acute Respiratory‐Tract Infections in All Age Groups

2002 ◽  
Vol 186 (9) ◽  
pp. 1330-1334 ◽  
Author(s):  
Guy Boivin ◽  
Yacine Abed ◽  
Gilles Pelletier ◽  
Louisette Ruel ◽  
Danielle Moisan ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Human Metapneumovirus ◽  
Acute Respiratory Tract Infections ◽  
Tract Infections

scholarly journals Molecular Diagnosis of Human Metapneumovirus in Hospitalized Children with Acute Respiratory Tract Infections using RT-LAMP: A Population-Based Prospective Study

2021 ◽  
Vol 11 (2) ◽  
pp. 146-150
Author(s):  
Ahmed Osman Gasim Attar ◽  
Khalid Enan ◽  
Sara Abdelghani ◽  
Lienda Bashier Eltayeb
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Clinical Symptoms ◽  
Diagnostic Technique ◽  
Lamp Assay ◽  
Human Metapneumovirus ◽  
Hospitalized Children ◽  
Age Group ◽  
Acute Respiratory Tract Infections ◽  
Tract Infections

Background: Human metapneumovirus (hMPV) is a major novel cause of acute respiratory infections ranging from wheezing to bronchiolitis and pneumonia in children worldwide. The aim of this study was to detect hMPV in hospitalized children with acute respiratory tract infections (ARTIs) by using reverse transcription-loop mediated isothermal amplification (RT-LAMP) assay. Methods and Results: A total of 68 children with ARTIs who were clinically suspected of acquiring hMPV were included in the study in the period between January 2019 and February 2020. Posterior-pharyngeal (throat) swabs were obtained from each patient. hMPV RNA was revealed in 18(26.5%) cases. The age range was from <1 year to 10 years (mean age of 5.25±2.62). Sixteen (23.5%) of the participants were in the age group of <1 year, where the majority of hMPV-positive subjects (n=11) were found (16.2% of the total number of infected children) (P=0.0025). The majority of hMPV-negative subjects (n=15) were found in the age group of 5-10 years (22% of the total number of infected children) (P=0.0025). Cough, fever, and shortness of breath were common symptoms in hMPV-positive children: 15(83.3%), 13(72.2%), and 12(66.7%), respectively. There was a statistically significant correlation between common clinical symptoms and the age group of hMPV-positive children: symptoms were common in the age group of <1 year. Conclusion: Our study represents the first report in Khartoum, Sudan, on the detection of hMPV using RT-LAMP. RT-LAMP is a valuable, quick diagnostic technique for hMPV detection.

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