scholarly journals Power Calculations for a General Class of Family-Based Association Tests: Dichotomous Traits

2002 ◽  
Vol 71 (3) ◽  
pp. 575-584 ◽  
Author(s):  
Christoph Lange ◽  
Nan M. Laird
Keyword(s):  
General Class ◽  
Association Tests ◽  
Power Calculations ◽  
Family Based

scholarly journals A comparative analysis of family-based and population-based association tests using whole genome sequence data

2014 ◽  
Vol 8 (Suppl 1) ◽  
pp. S33 ◽  
Author(s):  
Jin J Zhou ◽  
Wai-Ki Yip ◽  
Michael H Cho ◽  
Dandi Qiao ◽  
Merry-Lynn N McDonald ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Genome Sequence ◽  
Sequence Data ◽  
Population Based ◽  
Whole Genome Sequence ◽  
Whole Genome ◽  
Association Tests ◽  
Genome Sequence Data ◽  
Family Based

Investigation of the C242T polymorphism of NAD(P)H oxidase p22 phox gene and ischaemic heart disease using family-based association methods

2003 ◽  
Vol 105 (6) ◽  
pp. 677-682 ◽  
Author(s):  
M. S. SPENCE ◽  
P. G. McGLINCHEY ◽  
C. C. PATTERSON ◽  
A. R. ALLEN ◽  
G. MURPHY ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Case Control Studies ◽  
Association Tests ◽  
Pedigree Disequilibrium Test ◽  
C242t Polymorphism ◽  
Genetic And Environmental Factors ◽  
Family Based ◽  
P22 Phox

Ischaemic heart disease is a complex phenotype arising from the interaction of genetic and environmental factors. Excessive production of reactive oxygen species leading to endothelial dysfunction is believed to be important in the pathogenesis of ischaemic heart disease. The NAD(P)H oxidase system generates superoxide anions in vascular cells; however, the role of the C242T polymorphism of the NAD(P)H oxidase p22 phox gene in ischaemic heart disease is unclear due to contradictory results from case-control studies. Consequently, we applied family-based association tests to investigate the role of this polymorphism in ischaemic heart disease in a well-defined Irish population. A total of 1023 individuals from 388 families (discordant sibships and parent/child trios) were recruited. Linkage disequilibrium between the polymorphism and ischaemic heart disease was tested using the combined transmission disequilibrium test (TDT)/sib-TDT (cTDT) and pedigree disequilibrium test (PDT). Both cTDT and PDT analyses found no statistically significant excess transmission of either allele to affected individuals (P=0.30 and P=0.28, respectively). Using robust family-based association tests specifically designed for the study of complex diseases, we found no evidence that the C242T polymorphism of the p22 phox gene has a significant role in the development of ischaemic heart disease in our population.

Interpretation of simultaneous linkage and family-based association tests in genome screens

2007 ◽  
Vol 31 (2) ◽  
pp. 134-142 ◽  
Author(s):  
Ren-Hua Chung ◽  
Elizabeth R. Hauser ◽  
Eden R. Martin
Keyword(s):  
Association Tests ◽  
Family Based

Family-based association tests for ordinal traits adjusting for covariates

2006 ◽  
Vol 30 (8) ◽  
pp. 728-736 ◽  
Author(s):  
Xueqin Wang ◽  
Yuanqing Ye ◽  
Heping Zhang
Keyword(s):  
Association Tests ◽  
Ordinal Traits ◽  
Family Based

scholarly journals Neural Tube Defects and Folate Pathway Genes: Family-Based Association Tests of Gene–Gene and Gene–Environment Interactions

2006 ◽  
Vol 114 (10) ◽  
pp. 1547-1552 ◽  
Author(s):  
Abee L. Boyles ◽  
Ashley V. Billups ◽  
Kristen L. Deak ◽  
Deborah G. Siegel ◽  
Lorraine Mehltretter ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Association Tests ◽  
Gene Environment ◽  
Folate Pathway ◽  
Family Based
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