scholarly journals Neural Tube Defects and Folate Pathway Genes: Family-Based Association Tests of Gene–Gene and Gene–Environment Interactions

2006 ◽  
Vol 114 (10) ◽  
pp. 1547-1552 ◽  
Author(s):  
Abee L. Boyles ◽  
Ashley V. Billups ◽  
Kristen L. Deak ◽  
Deborah G. Siegel ◽  
Lorraine Mehltretter ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Association Tests ◽  
Gene Environment ◽  
Folate Pathway ◽  
Family Based

scholarly journals Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function

2008 ◽  
Vol 17 (23) ◽  
pp. 3675-3685 ◽  
Author(s):  
K. A. Burren ◽  
D. Savery ◽  
V. Massa ◽  
R. M. Kok ◽  
J. M. Scott ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Folate Deficiency ◽  
Gene Environment

Spina Bifida and Related Conditions

2017 ◽  
Author(s):  
Stephen L. Kinsman
Keyword(s):  
Spinal Cord ◽  
Spina Bifida ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Spinal Dysraphism ◽  
Gene Interactions ◽  
Tethered Spinal Cord ◽  
Spinal Lesion ◽  
Gene Environment ◽  
Spina Bifida Aperta

The term “spinal dysraphism” encompasses the broadest array of the conditions known as the neural tube defects. The open neural tube defects (spina bifida aperta and cystica) include both disorders of primary and/or secondary neuralation and are best defined as myelomeningocele complex (MMC) due to their protean nervous system manifestations beyond the spinal lesion. Closed spinal dysraphisms (so-called spina bifida occulta) include lipomatous lesions, forms of tethered spinal cord, sinus tracts, and forms of split spinal cord (diastematomyelia). Both genetic and environmental etiologies have been identified. Gene-environment and gene-gene interactions are also important in the pathobiology of these conditions.

Interaction between SNPs in folate pathway genes and environment increase neural tube defects risk

2014 ◽  
Vol 9 (4) ◽  
pp. 397-400
Author(s):  
Yunping Lei ◽  
Rachel K Tittle ◽  
Richard H Finnell
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Folate Pathway ◽  
Genes And Environment

ISDN2012_0272: Tortillas and toxins: Gene–environment interactions in fumonisin‐induced neural tube defects

2012 ◽  
Vol 30 (8) ◽  
pp. 636-636
Author(s):  
J. Gelineau‐van Waes ◽  
J. Maddox ◽  
M. Rainey ◽  
N. Gardner ◽  
A. Sachs ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Environment

Neural tube defects in curly-tail mice. II. Effect of maternal administration of vitamin A

1979 ◽  
Vol 206 (1162) ◽  
pp. 95-107 ◽  
Keyword(s):  
Vitamin A ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Neural Tube Closure ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Curly Tail ◽  
The Central Nervous System ◽  
Maternal Administration

Vitamin A, a known teratogen of the central nervous system, was administered in various doses, at the time of active neural tube closure, to pregnant curly-tail mice which have a genetic predisposition to neural tube defects (n. t. d. ), and to A Strong mice, which are not so predisposed. The curly-tail mice showed an enhanced susceptibility to the terato­genic effect of vitamin A given on day 8 of gestation, demonstrating a clear gene─environment interaction. There was a differential response by the two sexes. Females seemed to be more affected by the vitamin A than males. When vitamin A was administered on day 9, instead of day 8, of gestation, the incidence of n. t. d. decreased rather than increased. Furthermore, the number of mice affected by n. t. d. was markedly lower even than that found spontaneously in untreated curly-tail mice.

Folate pathway gene alterations in patients with neural tube defects

2000 ◽  
Vol 95 (3) ◽  
pp. 216-223 ◽  
Author(s):  
Patrizia De Marco ◽  
Anna Moroni ◽  
Elisa Merello ◽  
Raffaella de Franchis ◽  
Luciano Andreussi ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Pathway Gene ◽  
Folate Pathway ◽  
Gene Alterations

Interaction between Maternal and Paternal SHMT1 C1420T Predisposes to Neural Tube Defects in the Fetus: Evidence from Case-Control and Family-Based Triad Approaches

2017 ◽  
Vol 109 (13) ◽  
pp. 1020-1029 ◽  
Author(s):  
Prasoona K. Rebekah ◽  
Sunitha Tella ◽  
Srinadh Buragadda ◽  
Muni Kumari Tiruvatturu ◽  
Jyothy Akka
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Case Control ◽  
Family Based

Investigation of Folate Pathway Gene Polymorphisms and the Incidence of Neural Tube Defects in a Texas Hispanic Population

2000 ◽  
Vol 70 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Robert Barber ◽  
Stuart Shalat ◽  
Kate Hendricks ◽  
Brigitte Joggerst ◽  
Russell Larsen ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Hispanic Population ◽  
Pathway Gene ◽  
Folate Pathway
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