scholarly journals Absence of Age Effect on Meiotic Recombination between Human X and Y Chromosomes

2002 ◽  
Vol 71 (2) ◽  
pp. 254-261 ◽  
Author(s):  
Qinghua Shi ◽  
Elizabeth Spriggs ◽  
L. Leigh Field ◽  
Alfred Rademaker ◽  
Evelyn Ko ◽  
...  
Keyword(s):  
Meiotic Recombination ◽  
Age Effect ◽  
Y Chromosomes

scholarly journals RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes

2022 ◽  
Vol 8 (2) ◽  
Author(s):  
Hui Ma ◽  
Tao Li ◽  
Xuefeng Xie ◽  
Long Jiang ◽  
Jingwei Ye ◽  
...  
Keyword(s):  
Meiotic Recombination ◽  
Y Chromosomes

RAD51AP2 is required specifically for efficient meiotic recombination to form crossover between X and Y chromosomes.

scholarly journals ANKRD31 regulates spatiotemporal patterning of meiotic recombination initiation and ensures recombination between heterologous sex chromosomes in mice

2018 ◽  
Author(s):  
Frantzeskos Papanikos ◽  
Julie A.J. Clément ◽  
Erika Testa ◽  
Ramya Ravindranathan ◽  
Corinne Grey ◽  
...  
Keyword(s):  
Sex Chromosomes ◽  
Meiotic Recombination ◽  
Meiotic Chromosome ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Homologous Chromosomes ◽  
Y Chromosomes ◽  
Genome Wide ◽  
A Genome ◽  
Pseudoautosomal Regions

AbstractOrderly segregation of chromosomes during meiosis requires that crossovers form between homologous chromosomes by recombination. Programmed DNA double-strand breaks (DSBs) initiate meiotic recombination. We identify ANKRD31 as a critical component of complexes of DSB-promoting proteins which assemble on meiotic chromosome axes. Genome-wide, ANKRD31 deficiency causes delayed recombination initiation. In addition, loss of ANKRD31 alters DSB distribution owing to reduced selectivity for sites that normally attract DSBs. Strikingly, ANKRD31 deficiency also abolishes uniquely high rates of recombination that normally characterize pseudoautosomal regions (PARs) of X and Y chromosomes. Consequently, sex chromosomes do not form crossovers leading to chromosome segregation failure in ANKRD31-deficient spermatocytes. These defects are accompanied by a genome-wide delay in assembling DSB-promoting proteins on axes and a loss of a specialized PAR-axis domain that is highly enriched for DSB-promoting proteins. Thus, we propose a model for spatiotemporal patterning of recombination by ANKRD31-dependent control of axis-associated complexes of DSB-promoting proteins.

878-P: Real-World Data from U.S. Patients Using a Long-Term Implantable Continuous Glucose Monitoring (CGM) System: Age Effect on Glycemic Control

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 878-P
Author(s):  
KATHERINE TWEDEN ◽  
SAMANWOY GHOSH-DASTIDAR ◽  
ANDREW D. DEHENNIS ◽  
FRANCINE KAUFMAN
Keyword(s):  
Glycemic Control ◽  
Continuous Glucose Monitoring ◽  
Real World ◽  
Glucose Monitoring ◽  
Age Effect ◽  
Real World Data ◽  
World Data
Sign in / Sign up

Export Citation Format

Share Document