scholarly journals The Origin of Hepatitis C Virus Reinfecting Transplanted Livers: Serum‐Derived versus Peripheral Blood Mononuclear Cell–Derived Virus

2002 ◽  
Vol 185 (4) ◽  
pp. 417-421 ◽  
Author(s):  
Tomasz Laskus ◽  
Marek Radkowski ◽  
Jeffrey Wilkinson ◽  
Hugo Vargas ◽  
Jorge Rakela
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Peripheral Blood Mononuclear Cell ◽  
Mononuclear Cell ◽  
Peripheral Blood ◽  
Peripheral Blood Mononuclear

scholarly journals Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets

2005 ◽  
Vol 86 (9) ◽  
pp. 2507-2512 ◽  
Author(s):  
Eriko Yamada ◽  
Maria Montoya ◽  
Christian G. Schuettler ◽  
Timothy P. Hickling ◽  
Alexander W. Tarr ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Peripheral Blood Mononuclear Cell ◽  
Mononuclear Cell ◽  
Peripheral Blood ◽  
Type I ◽  
Cell Infection ◽  
Virus Genotype ◽  
Peripheral Blood Mononuclear ◽  
Genotype 1A

Hepatitis C virus (HCV) binding to hepatocytes is thought to be mediated via interaction of the E2 glycoprotein with (co-)receptors including CD81 and scavenger receptor class B type I (SR-BI). Here, the expression of CD81 and SR-BI was analysed on peripheral blood mononuclear cell (PBMC) subsets, and the binding of genotype 1 soluble truncated E2 (sE2) proteins to these cells was investigated. All PBMC subsets expressed CD81, although at varying levels. In contrast, SR-BI was only detected on monocytes and dendritic cells (DCs). The genotype 1a H77c sE2 protein showed higher PBMC binding than other genotype 1a/b sE2s. H77c sE2 binding to different PBMC subsets largely paralleled their level of CD81 expression, and could be inhibited by blocking E2–CD81 interaction. However, those PBMC subsets reported to be infected by HCV in vivo (monocytes, DCs and B cells) also exhibited residual, CD81-independent binding, indicating roles for SR-BI/other receptor(s) in mediating haematopoietic cell infection.

New evidence of replication of hepatitis C virus in short-term peripheral blood mononuclear cell cultures

2014 ◽  
Vol 191 ◽  
pp. 1-9 ◽  
Author(s):  
Federico Alejandro Di Lello ◽  
Andrés Carlos Alberto Culasso ◽  
Cecilia Parodi ◽  
Patricia Baré ◽  
Rodolfo Héctor Campos ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Peripheral Blood Mononuclear Cell ◽  
Mononuclear Cell ◽  
Cell Cultures ◽  
Peripheral Blood ◽  
Short Term ◽  
Peripheral Blood Mononuclear ◽  
New Evidence
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