scholarly journals Serum Level of Soluble Intercellular Adhesion Molecule 1 in Patients with Chronic Liver Disease Related to Hepatitis C Virus: A Prognostic Marker for Responses to Interferon Treatment

2000 ◽  
Vol 181 (2) ◽  
pp. 425-431 ◽  
Author(s):  
Franco Capra ◽  
Elena De Maria ◽  
Claudio Lunardi ◽  
Luigi Marchiori ◽  
Paolo Mezzelani ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Serum Level ◽  
Chronic Liver Disease ◽  
Adhesion Molecule ◽  
Intercellular Adhesion Molecule ◽  
Interferon Treatment ◽  
Intercellular Adhesion Molecule 1 ◽  
Soluble Intercellular Adhesion Molecule

Serum Levels of Soluble Intercellular Adhesion Molecule-1 and Soluble Vascular Cell Adhesion Molecule-1 in Liver Disease, and Their Changes by Treatment with Interferon

1996 ◽  
Vol 24 (3) ◽  
pp. 258-265 ◽  
Author(s):  
A Marui ◽  
Y Fukuda ◽  
Y Koyama ◽  
I Nakano ◽  
F Urano ◽  
...  
Keyword(s):  
Liver Disease ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Serum Levels ◽  
Intercellular Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
Intercellular Adhesion Molecule 1 ◽  
Vascular Cell ◽  
Soluble Intercellular Adhesion Molecule ◽  
Cell Adhesion Molecule 1

Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured by an enzyme-linked immunosorbent assay in patients with chronic hepatitis ( n = 57), liver cirrhosis ( n = 19) and hepatocellular carcinoma (n = 33). Serum levéis of sICAM-1 and sVCAM-1 were significantly higher in liver disease than those in controls ( P < 0.0001 and P < 0.0005, respectively). A total of 22 patients with chronic hepatitis C were treated with interferon. Pretreatment levels of sICAM-1 and sVCAM-1 were not significantly different between complete responders and non-responders. In complete responders, serum sICAM-1 and sVCAM-1 levels 1 year after interferon treatment significantly decreased compared to the pretreatment levels ( P < 0.005 and P < 0.05, respectively). Post-treatment levels of sICAM-1 and sVCAM-1 in complete responders were also significantly lower than those in non-responders ( P < 0.005 and P < 0.05, respectively). This suggests that monitoring soluble adhesion molecules might be useful in the follow-up of patients with liver disease.

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