scholarly journals Human Herpesvirus 8 Cellular Immune Responses in Homosexual Men

1999 ◽  
Vol 180 (5) ◽  
pp. 1682-1685 ◽  
Author(s):  
Howard D. Strickler ◽  
James J. Goedert ◽  
F. R. Bethke ◽  
C. M. Trubey ◽  
Thomas R. O'Brien ◽  
...  
Keyword(s):  
Immune Responses ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Homosexual Men ◽  
Herpesvirus 8 ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Identification of Human Herpesvirus 8-Specific Cytotoxic T-Cell Responses

1999 ◽  
Vol 73 (7) ◽  
pp. 6136-6140 ◽  
Author(s):  
Mohamed Osman ◽  
Toru Kubo ◽  
Jasjit Gill ◽  
Frank Neipel ◽  
Marion Becker ◽  
...  
Keyword(s):  
Immune Responses ◽  
Kaposi's Sarcoma ◽  
Human Herpesvirus ◽  
Kaposi’S Sarcoma ◽  
Human Herpesvirus 8 ◽  
Cytotoxic T Cell ◽  
Herpesvirus 8 ◽  
Cellular Immune Responses ◽  
Cytotoxic T Cell Responses ◽  
Cellular Immune

ABSTRACT Human herpesvirus 8 (HHV-8) (or Kaposi’s sarcoma-associated herpesvirus) is implicated in the etiopathogenesis of Kaposi’s sarcoma (KS) and certain lymphoproliferations. The introduction of more effective therapies to treat human immunodeficiency virus infection has led to a decline in the incidence of KS and also in the resolution of KS in those already affected. This suggests that cellular immune responses including cytotoxic T lymphocytes (CTLs) could play a vital role in the control of HHV-8 infection and in KS pathogenesis. Here we elucidate HLA class I-restricted, HHV-8-specific cellular immune responses that could be important in the control of HHV-8 infection and subsequent tumor development. We show the presence of CTLs against HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in infected individuals.

scholarly journals Increased Human Herpesvirus 8 Seroprevalence in Young Homosexual Men Who Have Multiple Sex Contacts with Different Partners

1999 ◽  
Vol 179 (1) ◽  
pp. 237-239 ◽  
Author(s):  
David J. Blackbourn ◽  
Dennis Osmond ◽  
Jay A. Levy ◽  
Evelyne T. Lennette
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Homosexual Men ◽  
Herpesvirus 8

Changes in the Immune Responses Against Human Herpesvirus-8 in the Disease Course of Posttransplant Kaposi Sarcoma

2008 ◽  
Vol 86 (5) ◽  
pp. 738-744 ◽  
Author(s):  
Patrizia Barozzi ◽  
Chiara Bonini ◽  
Leonardo Potenza ◽  
Michele Masetti ◽  
Gianni Cappelli ◽  
...  
Keyword(s):  
Immune Responses ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Disease Course ◽  
Herpesvirus 8

scholarly journals Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species

Viruses ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1108 ◽  
Author(s):  
Joachim Denner ◽  
Tarin M. Bigley ◽  
Tuan L. Phan ◽  
Cosima Zimmermann ◽  
Xiaofeng Zhou ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Immune Responses ◽  
Neurological Diseases ◽  
Human Herpesvirus ◽  
Febrile Seizures ◽  
Porcine Cytomegalovirus ◽  
Cellular Immune Responses ◽  
High Prevalence ◽  
Disease Associations ◽  
Cellular Immune

Viruses of the genus Roseolovirus belong to the subfamily Betaherpesvirinae, family Herpesviridae. Roseoloviruses have been studied in humans, mice and pigs, but they are likely also present in other species. This is the first comparative analysis of roseoloviruses in humans and animals. The human roseoloviruses human herpesvirus 6A (HHV-6A), 6B (HHV-6B), and 7 (HHV-7) are relatively well characterized. In contrast, little is known about the murine roseolovirus (MRV), also known as murine thymic virus (MTV) or murine thymic lymphotrophic virus (MTLV), and the porcine roseolovirus (PRV), initially incorrectly named porcine cytomegalovirus (PCMV). Human roseoloviruses have gained attention because they can cause severe diseases including encephalitis in immunocompromised transplant and AIDS patients and febrile seizures in infants. They have been linked to a number of neurological diseases in the immunocompetent including multiple sclerosis (MS) and Alzheimer’s. However, to prove the causality in the latter disease associations is challenging due to the high prevalence of these viruses in the human population. PCMV/PRV has attracted attention because it may be transmitted and pose a risk in xenotransplantation, e.g., the transplantation of pig organs into humans. Most importantly, all roseoloviruses are immunosuppressive, the humoral and cellular immune responses against these viruses are not well studied and vaccines as well as effective antivirals are not available.

Sexual behaviour and human herpesvirus 8 infection in homosexual men in Australia

Sexual Health ◽  
2005 ◽  
Vol 2 (1) ◽  
pp. 13 ◽  
Author(s):  
Andrew E. Grulich ◽  
Philip Cunningham ◽  
Mee-Ling Munier ◽  
Garrett Prestage ◽  
Janaki Amin ◽  
...  
Keyword(s):  
Sexual Behaviour ◽  
Sexual Transmission ◽  
Human Herpesvirus ◽  
Immunofluorescence Assay ◽  
Human Herpesvirus 8 ◽  
Homosexual Men ◽  
Anal Sex ◽  
Herpesvirus 8 ◽  
Sexually Transmitted ◽  
Receptive Anal Sex

Background: Human herpesvirus 8 (HHV-8) is a common sexually transmitted agent among homosexual men, but there are few Australian data. We aimed to describe the prevalence and risk factors for seropositivity to HHV-8 in Australian homosexual men. Methods: We conducted a prospective cohort study of 179 homosexual men in Sydney Australia in 1992–1998. Detailed data on sexual behaviour was collected annually, and HHV-8 status was determined at the end of the study by an algorithm based on results of an immunofluorescence assay and an enzyme-linked immunoassay to the K8.1 protein of HHV-8. HHV-8 DNA was detected in buffy coats using a nested qualitative PCR. Results: Data on sexual behaviour in at least three interviews and HHV-8 status were available in 174 (97%) of 179 men who agreed to participate. Of these, 31 (18%) were HHV-8 seropositive, and HHV-8 DNA was detected in 5 (16%) of these. The prevalence of HHV-8 infection was much higher in HIV positive (52%) than HIV negative (11%) men (OR 8.60, 95% CI 3.55–20.86). HHV-8 infection was related to more frequent reporting of unprotected receptive anal sex (OR for most frequent versus least frequent category 3.03, 95% CI 1.01–9.03, P trend 0.02), insertive oro–anal sex (OR for most frequent v. least frequent category 3.02, 95% CI 1.15–7.93, P trend 0.02) and receptive oro–anal sex (OR for most frequent v. least frequent category 3.09, 95% CI 1.11–8.60, P trend 0.05) with casual partners. Conclusions: These data are consistent with sexual transmission of HHV-8, but the precise mode of HHV-8 transmission remains unclear. Studies to elucidate the precise mode of sexual transmission of HHV-8 need to focus on potential salivary transmission, and should collect data on the HHV-8 infection and excretion status of the sexual partner.

Kaposi's sarcoma and human herpesvirus 8 infection do not protect HIV-1 infected homosexual men from AIDS dementia complex

AIDS ◽  
2001 ◽  
Vol 15 (16) ◽  
pp. 2165-2169 ◽  
Author(s):  
Neil Renwick ◽  
Gerrit Jan Weverling ◽  
Teysir Halaby ◽  
Peter Portegies ◽  
Margreet Bakker ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Human Herpesvirus ◽  
Kaposi’S Sarcoma ◽  
Aids Dementia Complex ◽  
Human Herpesvirus 8 ◽  
Homosexual Men ◽  
Herpesvirus 8 ◽  
Aids Dementia ◽  
Hiv 1

High Seroprevalence of Human Herpesvirus 8 Infection in HIV-positive Homosexual Men in Jiangsu Province, China

2017 ◽  
Vol 15 (4) ◽  
Author(s):  
Jiayan Li ◽  
Jinyun Song ◽  
Guolei Tan ◽  
Jianfang Wang ◽  
Zhenxian Zhou ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Jiangsu Province ◽  
Human Herpesvirus 8 ◽  
Hiv Positive ◽  
Homosexual Men ◽  
High Seroprevalence ◽  
Herpesvirus 8

scholarly journals Antibody Reactivity to Latent and Lytic Antigens to Human Herpesvirus–8 in Longitudinally Followed Homosexual Men

2003 ◽  
Vol 187 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Robert J. Biggar ◽  
Eric A. Engels ◽  
Denise Whitby ◽  
Dean H. Kedes ◽  
James J. Goedert
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Homosexual Men ◽  
Herpesvirus 8 ◽  
Antibody Reactivity
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