scholarly journals Varicella‐Zoster Virus–Specific Cellular Immunity in Subjects Given Acyclovir after Household Chickenpox Exposure

1999 ◽  
Vol 180 (3) ◽  
pp. 834-837 ◽  
Author(s):  
Takuji Kumagai ◽  
Makoto Kamada ◽  
Chiharu Igarashi ◽  
Kenji Yuri ◽  
Hidetsugu Furukawa ◽  
...  
Keyword(s):  
Varicella Zoster Virus ◽  
Cellular Immunity ◽  
Varicella Zoster

scholarly journals Studies on transfer of varicella-zoster-virus specific T-cell immunity from bone marrow donor to recipient

Blood ◽  
1990 ◽  
Vol 75 (3) ◽  
pp. 806-809 ◽  
Author(s):  
S Kato ◽  
H Yabe ◽  
M Yabe ◽  
M Kimura ◽  
M Ito ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
T Cell ◽  
Varicella Zoster Virus ◽  
Cellular Immunity ◽  
Marrow Transplantation ◽  
T Cell Immunity ◽  
Lymphoproliferative Response ◽  
Varicella Zoster ◽  
Cell Immunity

Abstract The transfer of antigen-specific cellular immunity in human bone marrow transplantation (BMT) was studied in 49 donor-recipient pairs, using a varicella-zoster-virus (VZV) specific lymphoproliferative response (LPR) assay. Posttransplant VZV-LPR could be serially measured in 31 long-term surviving recipients. VZV-specific T-cell immunity was detected in the early posttransplant period in 4 of 16 recipients who were, and whose donors were, immune to VZV before BMT, but two of those positive responses diminished in the first 100 days posttransplant. No positive response was detected in the immediate posttransplant period when either only the recipient or the donor was immune to VZV pretransplant. Herpes zoster or chickenpox developed in the recipients depending on a history of pretransplant VZV infection when the VZV-LPR became negative, and recovery from VZV infection was always followed by quick conversion of VZV-LPR. Long-lasting positive VZV-LPR was observed in the two recipients who experienced VZV infection in the immediate pretransplant period and received marrow graft from an immune donor. Our results indicate that a simple or direct transfer of VZV-specific cellular immunity from a marrow donor to a recipient cannot be expected in usual clinical bone marrow transplantation and that there might be a collaboration or recruitment of immune responses involving both donor and recipient that permits the VZV-LPR to remain positive posttransplant.

scholarly journals Altered Phenotype and Functionality of Varicella Zoster Virus–Specific Cellular Immunity in Individuals With Active Infection

2014 ◽  
Vol 211 (4) ◽  
pp. 600-612 ◽  
Author(s):  
David Schub ◽  
Eva Janssen ◽  
Sarah Leyking ◽  
Urban Sester ◽  
Gunter Assmann ◽  
...  
Keyword(s):  
Varicella Zoster Virus ◽  
Cellular Immunity ◽  
Active Infection ◽  
Varicella Zoster

scholarly journals Cellular Immunity to Varicella‐Zoster Virus in Patients with Major Depression

1998 ◽  
Vol 178 (s1) ◽  
pp. S104-S108 ◽  
Author(s):  
Michael Irwin ◽  
Carolyn Costlow ◽  
Heather Williams ◽  
Kamal Haydari Artin ◽  
Christina Y. Chan ◽  
...  
Keyword(s):  
Major Depression ◽  
Varicella Zoster Virus ◽  
Cellular Immunity ◽  
Varicella Zoster

Reduced cellular immunity to varicella zoster virus during treatment for acute lymphoblastic leukemia of childhood:In Vitro studies of possible mechanisms

1986 ◽  
Vol 6 (6) ◽  
pp. 472-480 ◽  
Author(s):  
Roger H. Giller ◽  
Raleigh A. Bowden ◽  
Myron J. Levin ◽  
Lynn J. Walker ◽  
David G. Tubergen ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Varicella Zoster Virus ◽  
Cellular Immunity ◽  
Lymphoblastic Leukemia ◽  
Varicella Zoster

Impaired specific cellular immunity to the varicella-zoster virus in patients with herpes zoster oticus

1996 ◽  
Vol 110 (10) ◽  
pp. 918-921 ◽  
Author(s):  
Minoru Ikeda ◽  
Kouichi Hiroshige ◽  
Yuzuru Abiko ◽  
Keiko Onoda
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Cellular Immunity ◽  
Bell’S Palsy ◽  
Skin Tests ◽  
Transformation Rate ◽  
Bell's Palsy ◽  
Varicella Zoster ◽  
Herpes Zoster Oticus ◽  
Zoster Sine Herpete

AbstractThe possible involvement of depression on cellular immunity in reactivation of varicella-zoster virus (VZV) in herpes zoster oticus was investigated. The subjects comprised 59 cases of herpes zoster oticus, 33 cases of herpes zoster sine herpete (ZSH) with facial paralysis, and 205 cases of Bell's palsy. The transformation rate of lymphocytes to phytohaemagglutinin in herpes zoster oticus tended to be lower than that in Bell's palsy. In skin tests with purified protein derivatives of tuberculin, the positivity rate in herpes zoster oticus was significantly lower than that in Bell's palsy (p<0.015). In skin tests using VZV antigen, the positivity rate in herpes zoster oticus and ZSH were significantly lower than that of Bell's palsy (p<0.001 andp<0.015, respectively). Thus, it was noted that cellular immunity, especially specific cellular immunity against VZV, was significantly depressed in herpes zoster oticus and ZSH. We consider that depression of specific cellular immunity plays an important role in triggering reactivation of VZV and onset of these diseases.

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