scholarly journals No Evidence for Significant Linkage between Bipolar Affective Disorder and Chromosome 18 Pericentromeric Markers in a Large Series of Multiplex Extended Pedigrees

1998 ◽  
Vol 62 (4) ◽  
pp. 916-924 ◽  
Author(s):  
James A. Knowles ◽  
Peter A. Rao ◽  
Tara Cox-Matise ◽  
Jo Ellen Loth ◽  
Gracielle M. de Jesus ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Large Series ◽  
Chromosome 18 ◽  
Extended Pedigrees ◽  
Significant Linkage

scholarly journals Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families

1999 ◽  
Vol 4 (1) ◽  
pp. 76-84 ◽  
Author(s):  
M M Nöthen ◽  
S Cichon ◽  
H Rohleder ◽  
S Hemmer ◽  
E Franzek ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Chromosome 18

Cytogenetic abnormalities on chromosome 18 associated with bipolar affective disorder or schizophrenia

1997 ◽  
Vol 170 (3) ◽  
pp. 278-280 ◽  
Author(s):  
Ole Mors ◽  
Henrik Ewald ◽  
Douglas Blackwood ◽  
Walter Muir
Keyword(s):  
Bipolar Disorder ◽  
Affective Disorder ◽  
Human Genetics ◽  
Bipolar Affective Disorder ◽  
Chromosome Abnormalities ◽  
Cross Linking ◽  
Chromosome 18 ◽  
Karyotype Abnormality

BackgroundA few recent linkage studies have shown a possible locus for bipolar disorder on chromosome 18. Cytogenetic studies may assist in the further localisation of susceptibility loci on this chromosome.MethodA search was made for abnormalities of chromosome 18 in two separate large cytogenetic databases. In Denmark detection of mental illness in subjects with chromosome abnormalities was done by cross-linking the two separate register of psychiatric and chromosome disorders. In Scotland the Cytogenetic Registry of the MRC Human Genetics Unit undertakes long-term clinical follow-up of all cases with chromosome abnormalities.ResultsCross-linking the two Danish register's revealed a family with the rare karyotype abnormality inv(18) (p11.3;q21.1) with one inversion carrier who also suffered from bipolar disorder. In this family there were two other cases of bipolar disorder, but the karyotype of these cases could not be established. One family in Scotland showed a case of schizophrenia in a carrier of inv(18) with the same breakpoints as the Danish family.ConclusionsWe suggest further studies of the 18p11.3 and 18q21.1 regions in order to identify genes involved in bipolar affective disorder and schizophrenia.

The Clinical Picture of Bipolar Affective Disorder in its Depressed Phase

1982 ◽  
Vol 141 (6) ◽  
pp. 558-562 ◽  
Author(s):  
Ian F. Brockington ◽  
Edward Altman ◽  
Valerie Hillier ◽  
Herbert Y. Meltzer ◽  
Surinder Nand
Keyword(s):  
Affective Disorder ◽  
Mental State ◽  
Clinical Picture ◽  
Bipolar Affective Disorder ◽  
Large Series ◽  
Depressed Patients

SummaryUsing structured psychiatric interviews, we searched for differences between depressed patients with bipolar affective disorder, and with other types of depression. The patients were taken from 2 large series, collected in London and Chicago. Some differences were found, but few more than would be expected by chance, in view of the large number of variables examined. The possible reasons for this failure are discussed. They include contamination of the groups, and the insensitivity of structured mental state inventories.

scholarly journals Linkage of Bipolar Affective Disorder to Chromosome 18 Markers in a New Pedigree Series

1997 ◽  
Vol 61 (6) ◽  
pp. 1397-1404 ◽  
Author(s):  
Francis J. McMahon ◽  
Penelope J. Hopkins ◽  
Jianfeng Xu ◽  
Melvin G. McInnis ◽  
Sarah Shaw ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Chromosome 18

Linkage Analysis of Manic Depression (Bipolar Affective Disorder) in Icelandic and British Kindreds using Markers on the Short Arm of Chromosome 18

1997 ◽  
Vol 47 (5) ◽  
pp. 268-278 ◽  
Author(s):  
G. Kalsi ◽  
C. Smyth ◽  
J. Brynjolfsson ◽  
R.S. Sherrington ◽  
J. O’Neill ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Manic Depression ◽  
Chromosome 18
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