scholarly journals Familial Nontoxic Multinodular Thyroid Goiter Locus Maps to Chromosome 14q but Does Not Account for Familial Nonmedullary Thyroid Cancer

1997 ◽  
Vol 61 (5) ◽  
pp. 1123-1130 ◽  
Author(s):  
Graham R. Bignell ◽  
Federico Canzian ◽  
Maryam Shayeghi ◽  
Markus Stark ◽  
Yin Y. Shugart ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Goiter ◽  
Chromosome 14Q

X-RAY FLUORESCENCE ANALYSIS IN THE DIAGNOSIS OF THYROID CANCER

2017 ◽  
pp. 39-45
Author(s):  
В. Зайчик ◽  
V. Zaychik ◽  
Г. Давыдов ◽  
G. Davydov
Keyword(s):  
Thyroid Cancer ◽  
Normal Tissue ◽  
Thyroid Tissue ◽  
Nodular Goiter ◽  
Fluorescence Analysis ◽  
Fluorescence Excitation ◽  
X Ray ◽  
Thyroid Goiter ◽  
Diagnosis Of Thyroid Cancer

Purpose: To investigate new possibilities of differential diagnosis of benign and malignant thyroid goiter lesions by means of energy dispersive X-ray fluorescence analysis (EDRFA). Material and methods: In the samples of thyroid tissue taken from people with intact thyroid gland (mostly died from trauma, n = 92), as well as in patients with nodular goiter (n = 79) and thyroid cancer (n = 40) bromine (Br), copper (Cu), iron (Fe), iodine (I), rubidium (Rb) and strontium (Sr) were investigated. To determine these elements, the methods of EDRPA have been developed using encapsulated sources with 109Cd and 241Am radionuclides for fluorescence excitation. Results: It is shown that the levels of the content of I, the ratios I / Cu and I / Rb, as well as the products of the ratios I / Cu ∙ (I / Rb) and (I / Br) ∙ (I / Cu) ∙ (I / Rb ) are highly informative markers of thyroid cancer. The accuracy of the developed methods and the reliability of the results obtained were confirmed by measurements of international certified comparison materials. Conclusion: The use of the proposed markers allows in vitro to differentiat thyroid cancer from benign nodes and normal tissue with sensitivity in the range of 86–100 %, specificity of 89–99 %, and accuracy within 90–99 %.

scholarly journals Progressive evolution of thyroid adenoma to thyroid carcinoma

2019 ◽  
Vol 42 (3) ◽  
pp. 146
Author(s):  
Aisyah Elliyanti
Keyword(s):  
Risk Factors ◽  
Nuclear Medicine ◽  
Risk Factor ◽  
Thyroid Cancer ◽  
Bone Scintigraphy ◽  
Pelvic Bone ◽  
Thyroid Adenoma ◽  
Thyroid Goiter ◽  
Increase In Risk

Nodules (adenomas), enlarged thyroid (goiter) and inflammation of the thyroid (thyroiditis) are the most important risk factors for thyroid cancer. Adenomas have the largest increase in risk. Objectives: to discuss two cases of adenomas goiter that became aggressive during follow-ups. Cases: Two patients, with an average age of 64 years, referred to Nuclear Medicine dr. M. Djamil Hospital in Padang for bone scintigraphy examination. Both patients had thyroid surgery and histopathology results were adenomas. However, after the removal surgery, the patients did not have proper follow-ups. Both patients developed pelvic pain. Bone scintigraphy showed an increase of radiopharmaceutical uptake at pelvic bones and computerized tomography (CT Scan) result showed destruction at the pelvic bone areas. Conclusions: These cases highlight the necessity for adenoma thyroid patients with a risk factor for thyroid cancer to have a complete follow-up program and sufficient length period.

scholarly journals Surgical treatment for anaplastic thyroid cancer

2003 ◽  
Vol 11 (3) ◽  
pp. 186-186
Author(s):  
Vladan Zivaljevic ◽  
Aleksandar Diklic ◽  
Ksenija Krgovic ◽  
Milena Kazic ◽  
Nevena Kalezic ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Histological Analysis ◽  
Anaplastic Thyroid Cancer ◽  
Fine Needle Biopsy ◽  
Endocrine Surgery ◽  
Papillary Thyroid ◽  
Anaplastic Transformation ◽  
Thyroid Goiter ◽  
Male Patients

Background: Anaplastic thyroid cancer is relatively rare but extremely aggressive neoplasm. The aim of the present paper was to study the possibility of surgery for anaplastic thyroid cancer. Methods: During 5-year period (from 1998 to 2002) in the Center for endocrine surgery, we found anaplastic thyroid cancer in 65 patients (44 female and 21 male patients) of median age 63 years (range: 37-88 years). Diagnosis was determined on the basis of histological analysis in operated patients or on cytology findings in case of patients who were not operated. Histological analysis confirmed anaplastic transformation of papillary thyroid cancer in 18 cases. Results In 50% patients we performed only fine needle biopsy, and in 37% patients operative biopsy or tumor reduction. We performed radical surgery hemithyroidectomy or total thyroidectomy, in 13% patients with anaplastic thyroid cancer. Thyroid goiter was present in 35% patients longer than a year before diagnosis of anaplastic cancer was made. Conclusion: Possibility of surgery for anaplastic thyroid cancer is very limited. In about one third of patients there were longstanding goiter or histological verified dedifferentiation of papillary thyroid cancer. These patients should have been operated before anaplastic transformation.

scholarly journals Tissue and serum samples of patients with papillary thyroid cancer with and without benign background demonstrate different altered expression of proteins

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2450 ◽  
Author(s):  
Mardiaty Iryani Abdullah ◽  
Ching Chin Lee ◽  
Sarni Mat Junit ◽  
Khoon Leong Ng ◽  
Onn Haji Hashim
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Serum Proteins ◽  
Thyroid Neoplasms ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Serum Samples ◽  
Altered Expression ◽  
Thyroid Goiter ◽  
Alpha 1 Antitrypsin

BackgroundPapillary thyroid cancer (PTC) is mainly diagnosed using fine-needle aspiration biopsy. This most common form of well-differentiated thyroid cancer occurs with or without a background of benign thyroid goiter (BTG).MethodsIn the present study, a gel-based proteomics analysis was performed to analyse the expression of proteins in tissue and serum samples of PTC patients with (PTCb; n = 6) and without a history of BTG (PTCa; n = 8) relative to patients with BTG (n = 20). This was followed by confirmation of the levels of proteins which showed significant altered abundances of more than two-fold difference (p< 0.01) in the tissue and serum samples of the same subjects using ELISA.ResultsThe data of our study showed that PTCa and PTCb distinguish themselves from BTG in the types of tissue and serum proteins of altered abundance. While higher levels of alpha-1 antitrypsin (A1AT) and heat shock 70 kDa protein were associated with PTCa, lower levels of A1AT, protein disulfide isomerase and ubiquitin-conjugating enzyme E2 N seemed apparent in the PTCb. In case of the serum proteins, higher abundances of A1AT and alpha 1-beta glycoprotein were detected in PTCa, while PTCb was associated with enhanced apolipoprotein A-IV and alpha 2-HS glycoprotein (AHSG). The different altered expression of tissue and serum A1AT as well as serum AHSG between PTCa and PTCb patients were also validated by ELISA.DiscussionThe distinctive altered abundances of the tissue and serum proteins form preliminary indications that PTCa and PTCb are two distinct cancers of the thyroid that are etiologically and mechanistically different although it is currently not possible to rule out that they may also be due other reasons such as the different stages of the malignant disease. These proteins stand to have a potential use as tissue or serum biomarkers to discriminate the three different thyroid neoplasms although this requires further validation in clinically representative populations.

scholarly journals Epidemiology of Thyroid Cancer in an Area of Epidemic Thyroid Goiter

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Antonio Cossu ◽  
Mario Budroni ◽  
Panagiotis Paliogiannis ◽  
Giuseppe Palmieri ◽  
Fabrizio Scognamillo ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Local Tumor ◽  
Tumor Registry ◽  
High Incidence ◽  
Increasing Trend ◽  
Thyroid Goiter ◽  
Epidemiological Characteristics ◽  
Tumor Registries ◽  
Economic And Social Impacts ◽  
Overall Mortality

The aim of this study was to analyze and describe the epidemiological characteristics and trends of thyroid cancer in the province of Sassari (Sardinia, Italy), an area with epidemic thyroid goiter, in the period 1992–2010. Data were obtained from the local tumor registry which makes part of a wider registry web, coordinated today by the Italian Association for Tumor Registries. An increasing trend in the incidence of thyroid cancer in the province of Sassari was evidenced. This trend seems to follow the general worldwide trend and does not seem to be related to the high incidence of thyroid goiter in the area. The frequencies of the different histological subtypes were similar to those reported in numerous national and international reports. Women are affected earlier than men and, therefore, suffer greater professional, economic, and social impacts. Overall mortality is low and a relative 5-year survival is excellent, especially in comparison to other malignancies.

Axitinib Shrinks Thyroid Cancer in Phase II Trial

2007 ◽  
Vol 40 (14) ◽  
pp. 22
Author(s):  
JANE SALODOF MACNEIL
Keyword(s):  
Thyroid Cancer ◽  
Phase Ii ◽  
Phase Ii Trial

Better Detection Key to Rise in Thyroid Cancer

2006 ◽  
Vol 39 (13) ◽  
pp. 16
Author(s):  
MARY ANN MOON
Keyword(s):  
Thyroid Cancer
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