scholarly journals PHYSIOLOGICAL ONTOGENY

1926 ◽  
Vol 9 (6) ◽  
pp. 781-788 ◽  
Author(s):  
Henry A. Murray ◽  

1. The Arrhenius equation giving the relationship between the velocity of chemical reaction and temperature, was found suitable for the special case of the contraction rate of embryonic heart muscle fragments. 2. There was no constancy in the values of µ for the rate of contraction in culture, nor was the scattering evenly distributed around certain (more than one) points. 3. There seemed to be no correlation between µ and other functions such as the contraction rate, the site from which the piece was removed, the age of the embryo, etc.

1977 ◽  
Vol 9 (1) ◽  
pp. 191-195 ◽  
Author(s):  
Thomas L. Sporleder ◽  
Robert A. Skinner

Several definitions of diversification exist. Typically, the concept is dynamic and refers to the relationship among various activities or enterprises in which the firm is engaged. As new activities are acquired by a firm from some existing base of activities, complementarity of the newly acquired activity relative to the existing base is subjectively determined. Judgment is rendered on whether the result represents diversification or conglomeration.Conventional wisdom has not succinctly differentiated between diversification and conglomeration. Some writers have considered conglomeration a special case of diversification [2, 7]. For purposes of this paper, this taxonomic argument need not be settled.


2021 ◽  
Vol 18 (180) ◽  
pp. 20210334
Author(s):  
Liane Gabora ◽  
Mike Steel

Natural selection successfully explains how organisms accumulate adaptive change despite that traits acquired over a lifetime are eliminated at the end of each generation. However, in some domains that exhibit cumulative, adaptive change—e.g. cultural evolution, and earliest life—acquired traits are retained; these domains do not face the problem that Darwin’s theory was designed to solve. Lack of transmission of acquired traits occurs when germ cells are protected from environmental change, due to a self-assembly code used in two distinct ways: (i) actively interpreted during development to generate a soma, and (ii) passively copied without interpretation during reproduction to generate germ cells. Early life and cultural evolution appear not to involve a self-assembly code used in these two ways. We suggest that cumulative, adaptive change in these domains is due to a lower-fidelity evolutionary process, and model it using reflexively autocatalytic and foodset-generated networks. We refer to this more primitive evolutionary process as self–other reorganization (SOR) because it involves internal self-organizing and self-maintaining processes within entities, as well as interaction between entities. SOR encompasses learning but in general operates across groups. We discuss the relationship between SOR and Lamarckism, and illustrate a special case of SOR without variation.


2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Ivan Batalov ◽  
Quentin Jallerat ◽  
Adam W Feinberg

The engineering of highly aligned cardiomyocytes into functional heart muscle remains a primary challenge in cardiac tissue engineering. Researchers have shown that micropatterned topography and chemistry as well as mechanical and electrical gradients are all effective at inducing some degree of alignment. However, which approach works best in terms of electromechanical function of the engineered cardiac muscle is still an active area of research. Because formation of new heart muscle in mammals primarily occurs during cardiogenesis, we asked whether the embryonic heart could be used as an instructive template for the design of more effective cardiac tissue engineering scaffolds. Specifically, we hypothesized that micropatterns of fibronectin based on fibronectin fibril size and architecture in embryonic myocardium could improve cardiomyocyte alignment relative to 20 μm wide, 20 μm spaced fibronectin lines, a control pattern used widely in the literature. To test this, we first imaged the fibronectin matrix in the ventricles of day-5 embryonic chick hearts and imaged this in 3D using a multiphoton microscope. This fibronectin structure was then converted into a photomask for photolithography and subsequent patterning of fibronectin onto cover slips using microcontact printing. Samples with the biomimetic patterns or control patterns were seeded with embryonic chick cardiomyocytes, cultured for 3 days and then stained and imaged to visualize the myofibrils. Image analysis to quantify alignment showed that the ability of the biomimetic pattern to induce cardiomyocyte alignment increased with cell density, suggesting that cell-cell interactions play an important role in the formation of aligned embryonic myocardium. Disruption of the cadherins junctions using blocking antibodies confirmed this conclusion. In the future we will use human induced pluripotent stem cell-derived cardiomyocytes to engineer more clinically-relevant human heart muscle and analyze electromechanical function of the tissues including contractile force and action potential propagation.


2021 ◽  
pp. 54-77
Author(s):  
Daniel Greco

This chapter defends the possible worlds framework for modeling the contents of belief. Both the threats against which the chapter defends it—the problems of coarse grain—and the ‘fragmentationist’ response it offers are familiar. At least as a sociological matter, the fragmentationist response has been unpersuasive, likely because it can look like an ad hoc patch—an unmotivated epicycle aimed at saving a flailing theory from decisive refutation. The chapter offers two responses to this charge. First, the problems of coarse grain aren’t unique to the possible worlds framework and indeed arise for anyone who accepts certain very attractive views about the relationship between beliefs, desires, and action. Second, the fragmentationist response to these problems is in fact a special case of an independently motivated, ‘modest’ approach to model-building in philosophy.


Geophysics ◽  
1976 ◽  
Vol 41 (4) ◽  
pp. 766-770 ◽  
Author(s):  
F. E. M. Lilley

Observed magnetotelluric data are often transformed to the frequency domain and expressed as the relationship [Formula: see text]where [Formula: see text] [Formula: see text] and [Formula: see text] [Formula: see text] represent electric and magnetic components measured along two orthogonal axes (in this paper, for simplicity, to be north and east, respectively). The elements [Formula: see text] comprise the magnetotelluric impedance tensor, and they are generally complex due to phase differences between the electric and magnetic fields. All quantities in equation (1) are frequency dependent. For the special case of “two‐dimensional” geology (where structure can be described as having a certain strike direction along which it does not vary), [Formula: see text] with [Formula: see text]. For the special case of “one‐dimensional” geology (where structure varies with depth only, as if horizontally layered), [Formula: see text] and [Formula: see text].


2014 ◽  
Vol 8 (2) ◽  
Author(s):  
Simone Elisabeth Lang

AbstractIn describing the position of the narrator, research in literary studies generally follows Gérard Genette’s pioneering theory of narrative in distinguishing between the homo- and heterodiegetic type of narrator. This categorization is not sufficient to allow the position of the narrator to be described properly. The different ways in which the terms are used in literary studies reveal a shortcoming in the distinction behind them. Even in Genette’s work, there is a contradiction between the definition and the names of the two categories: Genette defines homo- and heterodiegesis with reference to the narrator’s presence in the narrated story, whereas he elsewhere states that the diegesis (in the sense of FrenchThe present article aims to do just that, starting from a theoretical standpoint. Thus, the different types of narrator that are possible are sketched in outline, and then explained with the help of examples.I begin by exposing the problems that result from using the terms in Genette’s manner (1), in order then to develop a list of possible narratorial standpoints based on the one hand on the involvement of the narratorial instance in the narrated world and on the other on its involvement in the story. By establishing separation of the two aspects as a ground rule in this way, a number of misunderstandings that are due to the varied ways in which the terminology has been used to date can be overcome.There follows a description of those cases that are unambiguously hetero- and homodiegetic (2), after which the problematic cases are considered (3), yielding the different types of homodiegetic narration that are possible. This latter set of distinctions will, like the others, shed light on the contours of the different narratorial positions and thus be capable of being put profitably into practice in textual interpretation. Accordingly, what is suggested is a way of using the terms that is first unambiguous and second beneficial to the interpretation of works, thus doing justice to the heuristic importance of narratology (see Kindt/Müller 2003; Stanzel 2002, 19).Thus, whereas the concept of diegesis provides the foundation for a distinction based on an ontological criterion that divides homo- and heterodiegesis from each other, the relationship between story and narrator is used to describe various types of homodiegetic narration. In the process, there come to light two types that are distinguished from each other by involvement in events (›homodiegetic, in the story‹ and ›homodiegetic, not in the story‹ narrators). If the narrator is not involved in events, the question arises of whether it would in principle have been possible for him to be involved in events, which is the norm with ›homodiegetic, not in the story‹ narrators, or whether a physical impossibility is the reason for his lack of involvement in the story. A special case of the ›homodiegetic, not in the story‹ narrator can be derived from this: peridiegetic narration: whereas narratorial instances of the ›homodiegetic, in the story‹ and ›homodiegetic, not in the story‹ types could in principle have been involved in the action and those of the ›homodiegetic, in the story‹ type actually were, peridiegetic narrators are marked by the fact that they cannot have been involved in the events.In summary, it will be shown that the concept of homodiegesis – in particular in the form in which it has previously been used, where links with the action and appearance in the story were not kept distinct – is in effect an umbrella term that brings together a number of possible forms. There is a prominent distinction between the ›homodiegetic, in the story‹ and the ›homodiegetic, not in the story‹ types of narrator (these types are represented in the present article by the old lawyer in Leo Perutz’s »The Beaming Moon« and the narrator who is a friend of Nathanael in E. T. A. Hoffmann’s »Sandman« respectively). The different degrees of homodiegetic narrator, which have often been mentioned in previous research and are defined by the strength of the character’s presence in the narrated world (from an uninvolved witness to an autodiegetic protagonist), are also to be situated between these two poles.It will also be shown in the process that the case of the narrator who is, for reasons of physical difference, not involved in events (the peridiegetic narrator) should be treated as a form of homodiegesis (for instance the schoolmaster in Theodor Storm’s


1960 ◽  
Vol 33 (2) ◽  
pp. 502-509 ◽  
Author(s):  
J. Mandel ◽  
F. L. Roth ◽  
M. N. Steel ◽  
R. D. Stiehler

Abstract Ultimate elongation (strain at failure) can be used to assess the aging of all rubber vulcanizates. For this purpose, it appears that Equation (2) can be used to express the early part of the aging process, corresponding to a period of aging at room temperature of 10 or more years. Prediction of shelf aging from tests at two or more elevated temperatures is only possible if the relationship between aging and temperature is known. For some rubber compounds the Arrhenius equation appears to hold. In these instances, it provides an effective means for estimating shelf aging.


1999 ◽  
Vol 11 (4) ◽  
pp. 274-282 ◽  
Author(s):  
Takayoshi Yamada ◽  
◽  
Sushanta Kumar Saha ◽  
Nobuharu Mimura ◽  
Yasuyuki Funahashi ◽  
...  

We analyze stability of planar grasp using a 2D virtual spring model. A 2D virtual spring model is widely used to explore frictionless grasp, but the direction of contact force has not been studied for a grasped object displaced by external disturbance. Finger displacement is restricted to the normal at initial contact. We introduce a 2D spring model for a frictionless case. The direction of contact force is explicitly formulated. Using potential energy, we analyze stability of frictionless grasp and show that the 1D-spring model is a special case of our proposed 2D-spring model. Frictional grasp stability is also studied using rolling contact. Numerical examples of 2-fingered grasp demonstrate the effects of parameters such as spring stiffness and contact force. It is shown that an optimum force exists for stabilizing frictionless grasp. It is proved that friction enhances grasp stability from the relationship between frictionless and frictional stiffness matrices. Stiffness conditions for stabilizing 3-fingered grasp is clarified.


1941 ◽  
Vol 73 (1) ◽  
pp. 109-123 ◽  
Author(s):  
Gladys L. Hobby ◽  
Martin H. Dawson ◽  
Karl Meyer ◽  
Eleanor Chaffee

A comparative study of spreading factor and hyaluronidase in preparations from various sources revealed the following points of similarity and dissimilarity in the two reactions. 1. Similarities: (a) All preparations containing hyaluronidase also produced spreading. (b) Heating at 65° and 100°C. for 30 minutes produced a comparable effect on both reactions. (c) The demonstration of the presence of hyaluronic acid in skin offers a plausible explanation for the mechanism of spreading on the basis of hyaluronidase activity. 2. Dissimilarities: (a) No parallelism was observed in the degree of activity of spreading factor and hyaluronidase in the same preparations. (b) All preparations which produced spreading did not contain hyaluronidase. (c) Antisera to hyaluronidase preparations specifically and completely inhibited the activity of the homologous enzyme but did not inhibit the spreading factor in the same preparations. The significance of the similarities and dissimilarities between the two reactions is discussed. It is concluded that while hyaluronidase may play a rôle in the spreading reaction the phenomenon is a complex one and cannot be explained on the basis of a simple chemical reaction.


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