scholarly journals A CONTRIBUTION TO THE BACTERIOLOGY OF RHEUMATIC FEVER

1907 ◽  
Vol 9 (2) ◽  
pp. 186-206 ◽  
Author(s):  
James M. Beattie
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatism

The conclusions I would draw from this work are merely those stated in a former paper. 1. The results obtained by injections of streptococci are different from those produced by Micrococcus rheumaticus. 2. Micrococcus rheumaticus cannot be regarded as an attenuated streptococcus, nor acute rheumatism as an attenuated streptococcal pyæmia. 3. In uncomplicated cases of acute rheumatism the organism may not be found in the blood or in the joint exudates.

scholarly journals Sulphonamide compounds and acute rheumatism

1942 ◽  
Vol 42 (1) ◽  
pp. 20-22 ◽  
Author(s):  
A. J. Glazebrook ◽  
Scott Thomson
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Rheumatic Fever ◽  
Respiratory Tract Infection ◽  
Otitis Media ◽  
Acute Rheumatic Fever ◽  
Controlled Experiment ◽  
Acute Rheumatism ◽  
Streptococcal Tonsillitis

1. In a controlled experiment prontosil was used in the treatment of four cases of streptococcal tonsillitis. These cases subsequently developed acute rheumatism.2. Two cases of otitis media and one case of streptococcal pneumonia, not in the controlled experiment, were treated with sulphonamide and sulphapyridine respectively. These cases developed rheumatism as a complication.3. Haemolytic streptococci were recovered from twelve cases of respiratory tract infection which subsequently developed acute rheumatic fever.

scholarly journals A STUDY OF EXPERIMENTAL NON-HEMOLYTIC STREPTOCOCCUS LESIONS IN VITALLY STAINED RABBITS

1916 ◽  
Vol 24 (6) ◽  
pp. 739-758 ◽  
Author(s):  
Russell L. Cecil
Keyword(s):  
Rheumatic Fever ◽  
Vascular Endothelium ◽  
Infectious Endocarditis ◽  
Acute Rheumatism ◽  
Gradual Transition ◽  
Focal Lesions ◽  
Hemolytic Streptococcus ◽  
Acute Arthritis ◽  
Vital Stain ◽  
Myocardial Lesions

1. Repeated injections into rabbits of non-hemolytic streptococci isolated from human cases of infectious endocarditis or rheumatic fever will produce an acute arthritis in the rabbit similar in most respects to the arthritis of acute rheumatism. 2. Microscopical sections of the joints show a gradual transition from an acute exudative inflammation to advanced organization. 3. Endocarditis and pericarditis occur in a small percentage of cases, and focal lesions in the myocardium consisting of necrosis and the infiltration of cells are frequent. These focal lesions differ considerably from Aschoff's submiliary nodules. 4. Lesions in the kidneys and liver occur but are not characteristic. 5. By means of the vital stain it has been shown that the large endothelioid cells which play a prominent part in the joint and myocardial lesions belong to the group of so called macrophages or wandering cells and probably develop from the vascular endothelium.

RED HAIR AND RHEUMATIC FEVER

PEDIATRICS ◽  
1969 ◽  
Vol 43 (4) ◽  
pp. 590-590
Author(s):  
T. E. C.
Keyword(s):  
Family History ◽  
Rheumatic Fever ◽  
Acute Rheumatism ◽  
Popular Belief ◽  
Red Hair ◽  
The Family ◽  
History Of

A widely held popular belief in this country and in England until recently was that children with red hair were especially prone to develop rheumatic fever. Physicians as distinguished as Sir George Frederic Still (1868-1941) also shared this view as is shown in the following quotation which is taken from his famous textbook, Common Dlsorders and Diseases of Children. There is one further phenomenon which is noteworthy in rheumatic children and which is perhaps worth mentioning here, although it is necessarily noticeable also in adults-the association of red hair with rheumatism and rheumatic heredity. The following observation may serve to illustrate it. In four days there were amongst my out-patients eleven children with red hair. Of these, two were attending with articular rheumatism; one had occasional pain and swelling in the knees, his mother had red hair and frequent pain in the limbs, and her brother and sister had "rheumatic fever;" one had "pains in the knees" and his mother had "rheumatism;" three others showed a history of "rheumatic fever" in the mother or father; one was attending with chorea; one had a brother attending with articular rheumatism; only two out of the eleven showed no rheumatism or chorea in themselves or their families. Amongst 80 children with red hair (including the 11 already mentioned) 24 were attending with definite manifestations of acute rheumatism, articulan or cardiac or chorea; 6 had pains in the limb which were almost certainly rheumatic, and of the remaining 50 cases 17 showed a family history of acute rheumatism (including chorea) in parents or brothers or sisters; so that there was rheumatism either in the child or the family in 47 out of 80; i.e. in 58 percent.

scholarly journals An Investigation into the Cause of Rheumatic Fever in Children

1928 ◽  
Vol 28 (3) ◽  
pp. 237-249 ◽  
Author(s):  
P. Lazarus-Barlow
Keyword(s):  
Rheumatic Fever ◽  
Heart Muscle ◽  
Acute Rheumatism ◽  
Bacteriological Examination ◽  
Intravenous Inoculation

1. Bacteriological examination from the tonsils and post-nasal space in forty-six cases of acute and sub-acute rheumatism resulted in streptococci alone being isolated.2. The streptococci isolated fell into three groups, S. mitis, S. salivarius, and eleven strains of S. cardioarthritidis.3. Comparison of the strains of S. cardioarthritidis with strains isolated in America show them to be closely related.4. No evidence was found of an exotoxin.5. Evidence was found of the presence of an endotoxin or lysate which produces an antitoxin.6. Intravenous inoculation of the lysate into rabbits appears definitely to affect the heart muscle and lungs, and to some extent the liver and kidneys.

scholarly journals STUDIES ON THE RELATIONSHIP OF STREPTOCOCCUS HEMOLYTICUS TO THE RHEUMATIC PROCESS

1932 ◽  
Vol 56 (5) ◽  
pp. 651-676 ◽  
Author(s):  
Alvin F. Coburn ◽  
Ruth H. Pauli
Keyword(s):  
Rheumatic Fever ◽  
Disease Process ◽  
Infectious Agent ◽  
Normal Subjects ◽  
Acute Rheumatism ◽  
Recent Infection ◽  
Hemolytic Streptococcus ◽  
Close Relationship ◽  
Relationship Of ◽  
The Relationship

In the first two papers findings were presented which point to a close relationship between the incidence of rheumatic fever and the distribution of Streptococcus hemolyticus. The fact was emphasized that in the rheumatic subject a recrudescence of the disease process is usually preceded by pharyngeal infection with hemolytic streptococci. These organisms conspicuous in the throat flora during the period of infection preliminary to an attack of acute rheumatism fell into six antigenic groups and produced toxins which in 70 per cent were neutralized by a monovalent streptococcus antiserum. In the present study, four series of observations have been presented, demonstrating the development of immune bodies to hemolytic streptococcus during the course of rheumatic fever. The agglutination and complement fixation reactions of sera from patients with acute rheumatism suggest recent infection with streptococcus. Precipitin tests indicate that at the time of appearance of the rheumatic attack, individuals develop, in their blood, precipitins to the protein fractions of hemolytic streptococcus. That these precipitins may not be entirely specific is recognized from their cross-reactions with antigens of chemically related organisms. The studies made in association with E. W. Todd of England have demonstrated that at the onset of an attack of acute rheumatism, there occurs in each instance a rise in the antistreptolysin titer of the patient's serum. This titer is much higher than that observed in normal subjects or in patients with bacterial infection other than hemolytic streptococcus. This presence of antistreptolysin with an N.D. of 0.005 cc. is considered strong evidence of recent infection by hemolytic streptococcus. In conclusion, the relationship between the incidence of hemolytic streptococcus and the geographical distribution of rheumatic fever, the relationship between the recrudescence in the rheumatic subject and infection of the throat with hemolytic streptococcus, the development of immune bodies for hemolytic streptococcus at the onset of the rheumatic attack and the apparently specific relationship of antistreptolysin formation to infection with hemolytic streptococcus,—together this combined evidence indicates that the infectious agent initiating the rheumatic process is Streptococcus hemolyticus.

Monosymptomatic rheumatic fever - Chorea Sydenham

2006 ◽  
Vol 37 (06) ◽  
Author(s):  
A Bauer ◽  
B Püst ◽  
B Willig
Keyword(s):  
Rheumatic Fever
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