scholarly journals STUDIES ON HERPETIC INFECTION IN MICE

1943 ◽  
Vol 78 (4) ◽  
pp. 321-326 ◽  
Author(s):  
Howard B. Slavin ◽  
George Packer Berry
Keyword(s):  
Bone Marrow ◽  
Inclusion Bodies ◽  
Herpes Virus ◽  
Herpetic Infection ◽  
Suckling Mice ◽  
Direct Spread ◽  
The Central Nervous System ◽  
Herpès Virus ◽  
Renal Infection ◽  
Intranasal Instillation

Intranasal instillation of herpes virus in suckling mice results in specific lesions widely distributed in the viscera. The lungs are infected by aspiration of the virus. Virus disseminated by way of the blood establishes itself in endothelium in certain situations where parenchymal lesions result by direct spread from the vascular foci. Evidence of blood-borne infection was found frequently in the liver and spleen, less frequently in the suprarenals, and, in one instance, in the bone marrow. Renal infection appeared to be uriniferous. Lymph carriage of the virus also occurs, and lymph nodes draining infected areas were often found to contain herpetic inclusion bodies. Herpes virus seems incapable of invading the central nervous system of suckling mice by the vascular route.

scholarly journals STUDIES ON HERPETIC INFECTION IN MICE

1943 ◽  
Vol 78 (4) ◽  
pp. 315-320 ◽  
Author(s):  
Howard B. Slavin ◽  
George Packer Berry
Keyword(s):  
Herpes Virus ◽  
Herpetic Infection ◽  
Olfactory Pathways ◽  
Suckling Mice ◽  
Herpès Virus ◽  
The Brain

Instilled intranasally into suckling mice, a mouse-passaged strain of herpes virus (HF) reaches the brain by both the trigeminal and olfactory pathways.

Oral recurrent human herpes virus infection and bone marrow transplantation survival

2001 ◽  
Vol 91 (5) ◽  
pp. 552-556 ◽  
Author(s):  
Ricardo Santiago Gomez ◽  
Marcelo Antunes Carneiro ◽  
Leandro Napier Souza ◽  
Júnia Maria Netto Victória ◽  
Wellington Moraes de Azevedo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Virus Infection ◽  
Marrow Transplantation ◽  
Herpes Virus ◽  
Human Herpes ◽  
Herpes Virus Infection ◽  
Human Herpes Virus ◽  
Herpès Virus

Human herpes virus 6 encephalomyelitis after bone marrow transplantation: Report of an autopsy case

2010 ◽  
Vol 30 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Masayuki Shintaku ◽  
Daita Kaneda ◽  
Kohei Tada ◽  
Harutaka Katano ◽  
Tetsutaro Sata
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Herpes Virus ◽  
Autopsy Case ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Herpès Virus

scholarly journals STUDIES ON HERPETIC INFECTION IN MICE

1943 ◽  
Vol 78 (4) ◽  
pp. 305-313 ◽  
Author(s):  
George Packer Berry ◽  
Howard B. Slavin
Keyword(s):  
Passive Immunity ◽  
Rabbit Serum ◽  
Acquired Immunity ◽  
Herpetic Infection ◽  
Suckling Mice ◽  
High Degree ◽  
Old Mice ◽  
Intranasal Instillation ◽  
Swiss Strain ◽  
Immune Rabbit

Passive immunity, naturally acquired from immune mothers or artificially induced through the administration of immune rabbit serum, conferred on suckling mice of the albino Swiss strain a high degree of resistance against herpetic infection following the intranasal instillation of the virus. Antibodies, which could be readily demonstrated in the blood of 2-week-old mice, were received by the offspring of immune mothers primarily by the mammary route. Naturally acquired immunity declined rapidly when suckling was interrupted. Herpes virus was not recovered from the fetuses of either immune or infected, non-immune mothers.

Blood Dendritic Cells From Myeloma Patients Are Not Infected With Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8)

Blood ◽  
1998 ◽  
Vol 92 (2) ◽  
pp. 402-404 ◽  
Author(s):  
Qing Yi ◽  
Marianne Ekman ◽  
Doina Anton ◽  
Susanne Bergenbrant ◽  
Anders Österborg ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Cell Lines ◽  
Kaposi's Sarcoma ◽  
Herpes Virus ◽  
Bone Marrow Cells ◽  
Kaposi’S Sarcoma ◽  
Myeloma Cell ◽  
Herpès Virus ◽  
Marrow Cells

In recent studies, the sequence of Kaposi's sarcoma-associated herpes virus (KSHV) or human herpes virus-8 (HHV-8) was detected in dendritic cells (DC) of patients with multiple myeloma (MM). A concern was raised whether there is an causal association between the viral infection and development of these tumors. In the present study, we have examined DC generated from blood adherent cells from 8 Swedish MM patients at different clinical stages and 2 patients with monoclonal gammopathy of undetermined significance. In addition, 6 myeloma cell lines and bone marrow cells from 2 MM patients were also studied. By polymerase chain reaction (PCR), including nested PCR, no virus DNA was demonstrable in the patients' DC or in myeloma cell lines or fresh bone marrow cells. Moreover, no antibody against KSHV was found in the serum of these 10 patients. Thus, our results indicate that blood-derived DC of MM patients in Sweden usually are not infected with KSHV/HHV-8. This study also suggests that KSHV/HHV-8 is not regularly associated with MM and consequently does not play a primary role in the pathogenesis of these tumors.

scholarly journals Primary human herpes virus 6 infection transmitted from donor to recipient through bone marrow infusion

1998 ◽  
Vol 21 (10) ◽  
pp. 1063-1066 ◽  
Author(s):  
YL Lau ◽  
M Peiris ◽  
GCF Chan ◽  
ACL Chan ◽  
D Chiu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Herpès Virus ◽  
Marrow Infusion ◽  
Bone Marrow Infusion

Frequent detection of Human Herpes Virus-8 in bone marrow of Jordanian patients of multiple myeloma

2011 ◽  
Vol 35 (5) ◽  
pp. 471-474 ◽  
Author(s):  
Said I. Ismail ◽  
Ismail S. Mahmoud ◽  
Mohammad A.L. Salman ◽  
Maher A. Sughayer ◽  
Azmi M. Mahafzah
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus

scholarly journals Absence of Herpes Virus Entry Mediator (HVEM) Increases Bone Mass by Attenuating Receptor Activator of Nuclear Factor-κB ligand (RANKL)-Induced Osteoclastogenesis

Endocrinology ◽  
2012 ◽  
Vol 153 (10) ◽  
pp. 4808-4817 ◽  
Author(s):  
Woon-Ki Kim ◽  
Ok-Joo Sul ◽  
Eun-Kyung Choi ◽  
Mi-Hyun Lee ◽  
Choon-Soo Jeong ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Mass ◽  
Knockout Mice ◽  
Herpes Virus ◽  
Virus Entry ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Herpes Virus Entry Mediator ◽  
Receptor Activator ◽  
Herpès Virus

Abstract Herpes virus entry mediator (HVEM), which is constitutively expressed at a high level on myeloid lineage cells, is also expressed on bone marrow-derived macrophages, suggesting that it may play a role in bone metabolism by affecting osteoclasts (OC) derived from bone marrow-derived macrophages. To address this question, we evaluated bone mass by micro-computed tomography and the number and activity of OC by tartrate-resistant acid phosphatase (TRAP) and pit formation on dentine slices, comparing HVEM-knockout mice with wild-type mice. The absence of HVEM led to a higher bone mass and to decreased levels of serum collagen type I fragments and serum TRACP5b in vivo. In vitro HVEM deficiency resulted in a reduced number and activity of OC and an impaired receptor activator of nuclear factor-κB ligand signaling through reduced activation of nuclear factor-κB and of nuclear factor of activated T-cells cytoplasmic 1. Exogenous soluble HVEM decreased expression of TRAP, whereas soluble LIGHT (a ligand of HVEM) increased it, indicating the occurrence of a positive signaling through HVEM during osteoclastogenesis. Our findings indicate that HVEM regulates bone remodeling via action on OC. The higher bone mass in the femurs of HVEM-knockout mice could be, at least in part, due to attenuated osteoclastogenesis and bone resorption resulting from decreased receptor activator of nuclear factor-κB ligand signaling in the OC.

Acyclovir prophylaxis of oral herpes virus during bone marrow transplantation

1996 ◽  
Vol 32 (3) ◽  
pp. 158-162 ◽  
Author(s):  
J.B. Epstein ◽  
A. Ransier ◽  
C.H. Sherlock ◽  
J.J. Spinelli ◽  
D. Reece
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Herpes Virus ◽  
Oral Herpes ◽  
Herpès Virus ◽  
Acyclovir Prophylaxis
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