scholarly journals SERUM SICKNESS IN RABBITS

1931 ◽  
Vol 54 (4) ◽  
pp. 597-613 ◽  
Author(s):  
Mover S. Fleisher ◽  
Lloyd Jones
Keyword(s):  
Large Dose ◽  
Horse Serum ◽  
Serum Sickness ◽  
Normal Horse Serum ◽  
Single Large Dose

1. The injection of a single large dose of normal horse serum into rabbits results in the appearance 3 to 8 days later of erythematous and edematous reactions on the ears in 68.9 per cent of the animals. 2. The injections may be given by any of several routes and reactions appear when the site of injection is definitely distant from the ears. 3. Injections of various antisera into rabbits cause the appearance of similar reactions. 4. These reactions can be considered as manifestations of serum sickness in rabbits.

scholarly journals THE ANTIBODY RESPONSE IN THE HUMAN BEING AFTER INJECTION WITH NORMAL HORSE SERUM

1929 ◽  
Vol 50 (4) ◽  
pp. 431-437 ◽  
Author(s):  
Louis Tuft ◽  
Susan Griffith Ramsdell
Keyword(s):  
Antibody Response ◽  
Specific Antibody ◽  
Horse Serum ◽  
Immune Serum ◽  
Serum Sickness ◽  
Human Being ◽  
Normal Horse Serum ◽  
Circulating Antibodies

After the injection of normal horse serum in the human being, serum sickness occurs even more regularly than in cases treated with the various immune sera, but this is not accompanied by the production, to any notable degree, of circulating antibodies of the various types that are regularly to be demonstrated after the administration of immune serum and its resulting serum sickness. Since normal horse serum therefore appears to be weakly antigenic, and immune serum highly antigenic for the human being, one must assume that this difference is the result of some alteration in its antigenic characteristics produced during the course of the immunization or of its preparation for use; or that the specific antibody which is responsible for the phenomenon of serum sickness has not yet been identified; or that this phenomenon is not in any way dependent on the presence of the various known antibodies to normal horse serum.

Dothiepin for depression: single nightly dosage

1977 ◽  
Vol 15 (23) ◽  
pp. 92-92
Keyword(s):  
Single Dose ◽  
Depressed Patient ◽  
Large Dose ◽  
Half Life ◽  
Dosage Regimen ◽  
The Body ◽  
Dry Mouth ◽  
Blurred Vision ◽  
Depressed Patients ◽  
Single Large Dose

Depressed patients tend to be forgetful, and for them a simple dosage regimen is particularly appropriate. The use of a single daily dosage depends on the drug having a relatively long (over 36 hours) half-life in the body and being tolerated in a single large dose. Many tricyclic anti-depressives fulfil these requirements provided that the single dose is given before the patient goes to bed. Unwanted effects such as dry mouth and blurred vision, which are troublesome during the day, are not a problem during sleep. The sedative actions of many of these drugs can help the insomniac depressed patient who might otherwise need a separate hypnotic.

scholarly journals QUANTITATIVE STUDIES OF THE PHOTOCHEMICAL DESPECIATION OF HORSE SERUM

1942 ◽  
Vol 76 (5) ◽  
pp. 451-476 ◽  
Author(s):  
J. P. Henry
Keyword(s):  
Visible Light ◽  
Guinea Pigs ◽  
Phosphotungstic Acid ◽  
Horse Serum ◽  
Wave Length ◽  
Thin Layers ◽  
Antigenic Specificity ◽  
Residual Content ◽  
Quantitative Studies ◽  
Normal Horse Serum

1. Normal horse serum was irradiated for periods of 3 to 4 days, with visible light or with ultraviolet light of known intensity and wave length. The photosensitizer hematoporphyrin was employed in some instances. The serum was exposed to the air in thin layers, and thoroughly agitated throughout irradiation. 2. The irradiated sera were unchanged in color, and over 90 per cent of the original protein content remained precipitable by phosphotungstic acid. 3. Studies of the antigenicity of the sera were carried out on guinea pigs and rabbits. Fresh antigenicities of deviated specificity and of an activity of the order of 1/50th, 1/1,000th, and less than 1/20,000th that of normal horse serum were obtained. The residual content of material having the same antigenic specificity as normal horse serum was estimated as approximately equivalent in activity to dilutions of normal horse serum of 1 cc., 1/10 cc., and less than 1/100 cc. per litre respectively.

Nephrotoxicity and Oxidative Stress of Single Large Dose or Two Divided Doses of Gentamicin in Rats

2011 ◽  
Vol 14 (11) ◽  
pp. 627-633 ◽  
Author(s):  
Mahmoud Kandeel ◽  
Iman Abdelaziz ◽  
Nagwan Elhabashy ◽  
Hanaa Hegazy ◽  
Yasmin Tolba
Keyword(s):  
Oxidative Stress ◽  
Large Dose ◽  
And Oxidative Stress ◽  
Single Large Dose
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