scholarly journals Mesenteric lymph nodes at the center of immune anatomy

2006 ◽  
Vol 203 (3) ◽  
pp. 497-500 ◽  
Author(s):  
Andrew J. Macpherson ◽  
Karen Smith
Keyword(s):  
Dendritic Cells ◽  
Immune System ◽  
Lymph Nodes ◽  
Intestinal Mucosa ◽  
Tolerance Induction ◽  
Intestinal Bacteria ◽  
Mesenteric Lymph Nodes ◽  
Food Proteins ◽  
Mesenteric Lymph ◽  
Food Antigens

The surface of the intestinal mucosa is constantly assaulted by food antigens and enormous numbers of commensal microbes and their products, which are sampled by dendritic cells (DCs). Recent work shows that the mesenteric lymph nodes (MLNs) are the key site for tolerance induction to food proteins and that they also act as a firewall to prevent live commensal intestinal bacteria from penetrating the systemic immune system.

scholarly journals Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells

2006 ◽  
Vol 203 (3) ◽  
pp. 519-527 ◽  
Author(s):  
Tim Worbs ◽  
Ulrike Bode ◽  
Sheng Yan ◽  
Matthias W. Hoffmann ◽  
Gabriele Hintzen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immune System ◽  
Lymph Nodes ◽  
Oral Tolerance ◽  
Small Bowel Transplantation ◽  
Tolerance Induction ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Intestinal Immune System ◽  
Oral Tolerance Induction

Oral tolerance induction is a key feature of intestinal immunity, generating systemic nonresponsiveness to ingested antigens. In this study, we report that orally applied soluble antigens are exclusively recognized in the intestinal immune system, particularly in the mesenteric lymph nodes. Consequently, the initiation of oral tolerance is impeded by mesenteric lymphadenectomy. Small bowel transplantation reveals that mesenteric lymph nodes require afferent lymph to accomplish the recognition of orally applied antigens. Finally, oral tolerance cannot be induced in CCR7-deficient mice that display impaired migration of dendritic cells from the intestine to the mesenteric lymph nodes, suggesting that immunologically relevant antigen is transported in a cell-bound fashion. These results demonstrate that antigen transport via afferent lymphatics into the draining mesenteric lymph nodes is obligatory for oral tolerance induction, inspiring new therapeutic strategies to exploit oral tolerance induction for the prevention and treatment of autoimmune diseases.

In situ demonstration of migration of dendritic cells released from rat small intestine to mesenteric lymph nodes

2001 ◽  
Vol 120 (5) ◽  
pp. A183-A183
Author(s):  
H KOBAYASHI ◽  
H NAGATA ◽  
S MIURA ◽  
T AZUMA ◽  
H SUZUKI ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Small Intestine ◽  
Lymph Nodes ◽  
Rat Small Intestine ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

scholarly journals A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes

2018 ◽  
Vol 12 (1) ◽  
pp. 108-116
Author(s):  
Bibiana E. Barrios ◽  
Lisa Maccio-Maretto ◽  
F. Nicolás Nazar ◽  
Silvia G. Correa
Keyword(s):  
Food Intake ◽  
Lymph Nodes ◽  
Tolerance Induction ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

scholarly journals Analysis of Salmonella enterica Serotype-Host Specificity in Calves: Avirulence of S. enterica Serotype Gallinarum Correlates with Bacterial Dissemination from Mesenteric Lymph Nodes and Persistence In Vivo

2002 ◽  
Vol 70 (12) ◽  
pp. 6788-6797 ◽  
Author(s):  
Susan M. Paulin ◽  
Patricia R. Watson ◽  
Annette R. Benmore ◽  
Mark P. Stevens ◽  
Philip W. Jones ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Host Specificity ◽  
Intestinal Mucosa ◽  
Salmonella Enterica ◽  
Systemic Disease ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Oral Inoculation ◽  
Pass Through

ABSTRACT Host and bacterial factors that determine whether Salmonella serotypes remain restricted to the gastrointestinal tract or penetrate beyond the mucosa and cause systemic disease remain largely undefined. Here, factors influencing Salmonella host specificity in calves were assessed by characterizing the pathogenesis of different serotypes. Salmonella enterica serotype Dublin was highly virulent intravenously, whereas S. enterica serotype Choleraesuis was moderately virulent. Both serotypes were virulent in calves infected orally. In contrast, S. enterica serotypes Gallinarum and Abortusovis were avirulent by either route. Serotypes Dublin, Gallinarum, and Abortusovis colonized the intestinal tract 24 h after oral inoculation, yet only serotype Dublin was consistently recovered from systemic tissues. Serotypes Dublin and Gallinarum invaded bovine intestines in greater numbers and induced greater enteropathogenic responses than serotypes Choleraesuis and Abortusovis. However, only serotype Dublin was able to persist within the intestinal mucosa, and use of a novel cannulation model demonstrated that serotype Dublin was able to pass through the mesenteric lymph nodes in greater numbers than serotype Gallinarum. Together, these results suggest that initial interactions with the intestinal mucosa do not correlate with host specificity, although persistence within tissues and translocation via efferent lymphatics appear to be crucial for the induction of bovine salmonellosis.

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