scholarly journals INTERCELLULAR COMMUNICATION AND TISSUE GROWTH

1967 ◽  
Vol 33 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Werner R. Loewenstein ◽  
Yoshinobu Kanno
Keyword(s):  
Cancer Cells ◽  
Membrane Permeability ◽  
Intercellular Communication ◽  
Surface Membrane ◽  
Cell Cancer ◽  
Normal Liver ◽  
Liver Cells ◽  
Tissue Growth ◽  
Liver Cancers ◽  
Strong Barrier

Intercellular communication was examined with intracellular electrical techniques in primary and transplanted rat liver cancers. Normal liver cells communicate rather freely with each other through permeable junctional membranes. Cancer liver cells show no communication at all; their surface membrane is a strong barrier to diffusion all around the cell. Cancer cells induce alterations in membrane permeability in normal liver cells; communication among the latter is markedly reduced when cancer cells grow near them.

A study of structural differences between liver cancer cells and normal liver cells using FTIR spectroscopy

2015 ◽  
Vol 1099 ◽  
pp. 18-23 ◽  
Author(s):  
Daping Sheng ◽  
Fangcheng Xu ◽  
Qiang Yu ◽  
Tingting Fang ◽  
Junjun Xia ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Ftir Spectroscopy ◽  
Cancer Cells ◽  
Normal Liver ◽  
Liver Cells ◽  
Liver Cancer Cells ◽  
Structural Differences

Combination of ZnO Nanoparticle with Marine Sponge Derived Dipeptide for Enhanced Anticancer Efficacy in Liver Cancer Cells and their Toxicity Evaluation on Embryonic Zebrafish

2020 ◽  
Vol 16 ◽  
Author(s):  
Gayathri Karanam ◽  
Arumugam Madan Kumar ◽  
Chinmai Sriamulya Yerukalapudi ◽  
Nagabhishek Sirpu Natesh ◽  
Rajender Boddula ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Marine Sponge ◽  
Zno Nanoparticles ◽  
Normal Liver ◽  
Liver Cells ◽  
Zebrafish Embryos ◽  
Zno Nanoparticle ◽  
Anticancer Efficacy ◽  
Liver Cancer Cells

Background: Nanomaterials-based cancer therapy plays a significant role in increasing the therapeutic efficiency of anticancer drugs, reducing side effects and targeted delivery of the drug payloads. The present study was aimed to enhance the anticancer effect of a novel dipeptide isolated from marine sponge associated Bacillus pumilus AMK1 by formulating with Zinc oxide (ZnO) nanoparticles for the effective treatment against HepG2 liver cancer cells. Methods: The ZnO nanoparticles were synthesized by chemical method and size of the nanoparticle was characterized by Scanning electron microscope, X-Ray diffraction and Fourier-transform infrared spectroscopy. Further, The ZnO nanoparticles were conjugated with the isolated dipeptide and evaluated for anticancer activity. In addition, distinct morphological changes were observed by performing apoptotic staining methods such as propidium iodide staining and acridine orange/ ethidium bromide staining. Furthermore, embryotoxic and teratogenic effects of conjugated dipeptide on the development of zebrafish embryo were investigated in this study. Results: It was observed that conjugated dipeptide showed enhanced cytotoxicity against HepG2 liver cancer cells without any toxic effect on normal liver cells. ZnO with dipeptide showed a significant higher apoptosis of liver cancer cells with around 19% in early apoptosis and 53% in late apoptosis stage. The obtained results suggest that ZnO nanoparticle conjugated dipeptide initiated cytotoxicity through apoptotic death in HepG2 cells. The embryotoxic studies in zebrafish embryos revealed the LC50 197.0 µg/mL. These findings suggest that conjugated dipeptide affected the development of zebrafish embryos only at relatively higher concentrations. Conclusion: The experimental results demonstrate that Zno nanoparticle conjugated dipeptide has the potential to improve anticancer efficacy against liver cancer cells by inducing apoptosis in cancer cells without effecting normal liver cells.

scholarly journals Differences in the Properties and Mirna Expression Profiles between Side Populations from Hepatic Cancer Cells and Normal Liver Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23311 ◽  
Author(s):  
Wei-hui Liu ◽  
Kai-shan Tao ◽  
Nan You ◽  
Zheng-cai Liu ◽  
Hong-tao Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mirna Expression ◽  
Expression Profiles ◽  
Normal Liver ◽  
Liver Cells ◽  
Hepatic Cancer ◽  
Mirna Expression Profiles

scholarly journals Hepatic Arterial Buffer Response in Liver Radioembolization and Potential Use for Improved Cancer Therapy

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1537
Author(s):  
Stephan Walrand ◽  
Michel Hesse ◽  
Philippe d’Abadie ◽  
François Jamar
Keyword(s):  
Animal Studies ◽  
Liver Tumors ◽  
Clinical Trial Design ◽  
Normal Liver ◽  
Dose Ratio ◽  
Liver Cancers ◽  
Tumoral Cell ◽  
Flow Enhancement ◽  
Curative Intention ◽  
Tumoral Cells

Liver radioembolization is a treatment option for unresectable liver cancers, performed by infusion of 90Y or 166Ho loaded spheres in the hepatic artery. As tumoral cells are mainly perfused via the liver artery unlike hepatic lobules, a twofold tumor to normal liver dose ratio is commonly obtained. To improve tumoral cell killing while preserving lobules, co-infusion of arterial vasoconstrictor has been proposed but with limited success: the hepatic arterial buffer response (HABR) and hepatic vascular escape mechanism hamper the arterioles vasoconstriction. The proposed project aims to take benefit from the HABR by co-infusing a mesenteric arterial vasodilator: the portal flow enhancement inducing the vasoconstriction of the intra sinusoids arterioles barely impacts liver tumors that are mainly fed by novel and anarchic external arterioles. Animal studies were reviewed and dopexamine was identified as a promising safe candidate, reducing by four the hepatic lobules arterial flow. A clinical trial design is proposed. A four to sixfold improvement of the tumoral to normal tissue dose ratio is expected, pushing the therapy towards a real curative intention, especially in HCC where ultra-selective spheres delivery is often not possible.

scholarly journals INTERCELLULAR COMMUNICATION AND TISSUE GROWTH

1967 ◽  
Vol 33 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Werner R. Loewenstein ◽  
Richard D. Penn
Keyword(s):  
Intercellular Communication ◽  
Wound Closure ◽  
Cell Movement ◽  
Normal Growth ◽  
Tissue Growth ◽  
Cellular Communication ◽  
Mechanical Contact ◽  
Cell Systems ◽  
Intact State ◽  
Striking Contrast

Intercellular communication was examined in regenerating rat liver and urodele skin, two tissues of fast but normal growth. In both, cellular communication is in general as good as in their respective normal intact state. This stands in striking contrast to the lack of cellular communication in tissues with cancerous growth. Upon wounding of the urodele skin, the normally permeable junctional membranes of cells near the wound border seal themselves off, thereby insulating the interiors of the communicated cell systems from the exterior. When the cells of two opposing borders make mechanical contact in the course of wound closure, communication between them ensues within 30 min. Within this period all cell movement also ceases ("contact inhibition"). The possible implications of these findings in the control of tissue growth are discussed.

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