scholarly journals Nasser Rusan: Scoping out centrosomes

2017 ◽  
Vol 216 (12) ◽  
pp. 3889-3890
Author(s):  
Marie Anne O’Donnell
Keyword(s):  
Control Cell ◽  
Cell Behavior

Rusan investigates how centrosomes control cell behavior and differentiation during development.

A DNA-Mediated Chemically Induced Dimerization (D-CID) Nanodevice for Nongenetic Receptor Engineering To Control Cell Behavior

2018 ◽  
Vol 130 (32) ◽  
pp. 10383-10387 ◽  
Author(s):  
Hao Li ◽  
Miao Wang ◽  
Tianhui Shi ◽  
Sihui Yang ◽  
Jinghui Zhang ◽  
...  
Keyword(s):  
Control Cell ◽  
Cell Behavior ◽  
Chemically Induced ◽  
Chemically Induced Dimerization

Control Cell Behavior on Physical Topographical Surface

2004 ◽  
Vol 43 (6B) ◽  
pp. 3806-3809 ◽  
Author(s):  
Wen-Ta Su ◽  
Jung-Yen Yang ◽  
Chuan-Ding Lin ◽  
I-Ming Chu
Keyword(s):  
Control Cell ◽  
Cell Behavior

scholarly journals Steps in Mechanotransduction Pathways that Control Cell Morphology

2019 ◽  
Vol 81 (1) ◽  
pp. 585-605 ◽  
Author(s):  
Haguy Wolfenson ◽  
Bo Yang ◽  
Michael P. Sheetz
Keyword(s):  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Control Cell ◽  
Matrix Composition ◽  
Cell Behavior ◽  
Repeated Testing ◽  
Cellular Functions ◽  
Rigidity Sensing ◽  
Controlled Environments

It is increasingly clear that mechanotransduction pathways play important roles in regulating fundamental cellular functions. Of the basic mechanical functions, the determination of cellular morphology is critical. Cells typically use many mechanosensitive steps and different cell states to achieve a polarized shape through repeated testing of the microenvironment. Indeed, morphology is determined by the microenvironment through periodic activation of motility, mechanotesting, and mechanoresponse functions by hormones, internal clocks, and receptor tyrosine kinases. Patterned substrates and controlled environments with defined rigidities limit the range of cell behavior and influence cell state decisions and are thus very useful for studying these steps. The recently defined rigidity sensing process provides a good example of how cells repeatedly test their microenvironment and is also linked to cancer. In general, aberrant extracellular matrix mechanosensing is associated with numerous conditions, including cardiovascular disease, aging, and fibrosis, that correlate with changes in tissue morphology and matrix composition. Hence, detailed descriptions of the steps involved in sensing and responding to the microenvironment are needed to better understand both the mechanisms of tissue homeostasis and the pathomechanisms of human disease.

A DNA-Mediated Chemically Induced Dimerization (D-CID) Nanodevice for Nongenetic Receptor Engineering To Control Cell Behavior

2018 ◽  
Vol 57 (32) ◽  
pp. 10226-10230 ◽  
Author(s):  
Hao Li ◽  
Miao Wang ◽  
Tianhui Shi ◽  
Sihui Yang ◽  
Jinghui Zhang ◽  
...  
Keyword(s):  
Control Cell ◽  
Cell Behavior ◽  
Chemically Induced ◽  
Chemically Induced Dimerization

scholarly journals Matrix nanotopography as a regulator of cell function

2012 ◽  
Vol 197 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Deok-Ho Kim ◽  
Paolo P. Provenzano ◽  
Chris L. Smith ◽  
Andre Levchenko
Keyword(s):  
Signal Transduction ◽  
Cell Function ◽  
Control Cell ◽  
Signal Transduction Pathways ◽  
Cell Behavior ◽  
Powerful Means ◽  
Cell Processes ◽  
Chemical Factors ◽  
Physical Interactions

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition to soluble chemical factors, physical interactions between the cell and ECM regulate primary cell processes, including differentiation, migration, and proliferation. Advances in microtechnology and, more recently, nanotechnology provide a powerful means to study the influence of the ECM on cell behavior. By recapitulating local architectures that cells encounter in vivo, we can elucidate and dissect the fundamental signal transduction pathways that control cell behavior in critical developmental, physiological, and pathological processes.

scholarly journals Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Francisca Benavente ◽  
Katja M Piltti ◽  
Mitra J Hooshmand ◽  
Aileen A Nava ◽  
Anita Lakatos ◽  
...  
Keyword(s):  
Intracellular Signaling ◽  
Control Cell ◽  
Screening Strategy ◽  
Receptor Expression ◽  
Therapeutic Window ◽  
Cell Behavior ◽  
Human Neural Stem Cells ◽  
Cord Injury

C1q plays a key role as a recognition molecule in the immune system, driving autocatalytic complement cascade activation and acting as an opsonin. We have previously reported a non-immune role of complement C1q modulating the migration and fate of human neural stem cells (hNSC); however, the mechanism underlying these effects has not yet been identified. Here, we show for the first time that C1q acts as a functional hNSC ligand, inducing intracellular signaling to control cell behavior. Using an unbiased screening strategy, we identified five transmembrane C1q signaling/receptor candidates in hNSC (CD44, GPR62, BAI1, c-MET, and ADCY5). We further investigated the interaction between C1q and CD44 , demonstrating that CD44 mediates C1q induced hNSC signaling and chemotaxis in vitro, and hNSC migration and functional repair in vivo after spinal cord injury. These results reveal a receptor-mediated mechanism for C1q modulation of NSC behavior and show that modification of C1q receptor expression can expand the therapeutic window for hNSC transplantation.

scholarly journals Three Decades of Research on Recombinant Collagens: Reinventing the Wheel or Developing New Biomedical Products?

2020 ◽  
Vol 7 (4) ◽  
pp. 155
Author(s):  
Andrzej Fertala
Keyword(s):  
Mechanical Strength ◽  
Half Life ◽  
Food Industry ◽  
Control Cell ◽  
Building Blocks ◽  
Cell Behavior ◽  
Cosmetic Products ◽  
Animal Tissues ◽  
Food Industries ◽  
Potential Use

Collagens provide the building blocks for diverse tissues and organs. Furthermore, these proteins act as signaling molecules that control cell behavior during organ development, growth, and repair. Their long half-life, mechanical strength, ability to assemble into fibrils and networks, biocompatibility, and abundance from readily available discarded animal tissues make collagens an attractive material in biomedicine, drug and food industries, and cosmetic products. About three decades ago, pioneering experiments led to recombinant human collagens’ expression, thereby initiating studies on the potential use of these proteins as substitutes for the animal-derived collagens. Since then, scientists have utilized various systems to produce native-like recombinant collagens and their fragments. They also tested these collagens as materials to repair tissues, deliver drugs, and serve as therapeutics. Although many tests demonstrated that recombinant collagens perform as well as their native counterparts, the recombinant collagen technology has not yet been adopted by the biomedical, pharmaceutical, or food industry. This paper highlights recent technologies to produce and utilize recombinant collagens, and it contemplates their prospects and limitations.

Correlative TOF-SIMS and fluorescence microscopy analyses of surfaces used to control mammalian cell function

1996 ◽  
Vol 54 ◽  
pp. 1044-1045
Author(s):  
K.E. Healy ◽  
C.H. Thomas ◽  
A. Rezania ◽  
P.J. McKeown ◽  
C. D. McFarland ◽  
...  
Keyword(s):  
Cell Function ◽  
Serum Proteins ◽  
Control Cell ◽  
Analytical Techniques ◽  
Cell Behavior ◽  
Material Surface ◽  
Initial Surface ◽  
Adsorbed Proteins ◽  
A Cell ◽  
Biological Environment

A common theme in engineering surfaces for biomedical materials and devices is the control of cell behavior at the material-tissue interface. Multiple analytical techniques are required to fully characterize a material surface both prior to and after exposure to the biological environment. In addition, a full cadre of microscopy techniques are essential for understanding cell behavior to these surface engineered materials. At the heart of understanding the mechanisms that control cell function on solid materials is the adsorption of serum proteins, which ultimately dictates how a cell responds to a material. A great deal of complexity is introduced into the system by adsorbed proteins, since there are over 200 proteins in human blood, and that post adsorption changes in conformation could lead to altered function. Until recently it has been extremely difficult to correlate cell behavior with the initial surface chemistry of a material and the type of protein adsorbed to the surface.

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