A DNA-Mediated Chemically Induced Dimerization (D-CID) Nanodevice for Nongenetic Receptor Engineering To Control Cell Behavior

2018 ◽  
Vol 130 (32) ◽  
pp. 10383-10387 ◽  
Author(s):  
Hao Li ◽  
Miao Wang ◽  
Tianhui Shi ◽  
Sihui Yang ◽  
Jinghui Zhang ◽  
...  
Keyword(s):  
Control Cell ◽  
Cell Behavior ◽  
Chemically Induced ◽  
Chemically Induced Dimerization

A DNA-Mediated Chemically Induced Dimerization (D-CID) Nanodevice for Nongenetic Receptor Engineering To Control Cell Behavior

2018 ◽  
Vol 57 (32) ◽  
pp. 10226-10230 ◽  
Author(s):  
Hao Li ◽  
Miao Wang ◽  
Tianhui Shi ◽  
Sihui Yang ◽  
Jinghui Zhang ◽  
...  
Keyword(s):  
Control Cell ◽  
Cell Behavior ◽  
Chemically Induced ◽  
Chemically Induced Dimerization

Control Cell Behavior on Physical Topographical Surface

2004 ◽  
Vol 43 (6B) ◽  
pp. 3806-3809 ◽  
Author(s):  
Wen-Ta Su ◽  
Jung-Yen Yang ◽  
Chuan-Ding Lin ◽  
I-Ming Chu
Keyword(s):  
Control Cell ◽  
Cell Behavior

scholarly journals Steps in Mechanotransduction Pathways that Control Cell Morphology

2019 ◽  
Vol 81 (1) ◽  
pp. 585-605 ◽  
Author(s):  
Haguy Wolfenson ◽  
Bo Yang ◽  
Michael P. Sheetz
Keyword(s):  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Control Cell ◽  
Matrix Composition ◽  
Cell Behavior ◽  
Repeated Testing ◽  
Cellular Functions ◽  
Rigidity Sensing ◽  
Controlled Environments

It is increasingly clear that mechanotransduction pathways play important roles in regulating fundamental cellular functions. Of the basic mechanical functions, the determination of cellular morphology is critical. Cells typically use many mechanosensitive steps and different cell states to achieve a polarized shape through repeated testing of the microenvironment. Indeed, morphology is determined by the microenvironment through periodic activation of motility, mechanotesting, and mechanoresponse functions by hormones, internal clocks, and receptor tyrosine kinases. Patterned substrates and controlled environments with defined rigidities limit the range of cell behavior and influence cell state decisions and are thus very useful for studying these steps. The recently defined rigidity sensing process provides a good example of how cells repeatedly test their microenvironment and is also linked to cancer. In general, aberrant extracellular matrix mechanosensing is associated with numerous conditions, including cardiovascular disease, aging, and fibrosis, that correlate with changes in tissue morphology and matrix composition. Hence, detailed descriptions of the steps involved in sensing and responding to the microenvironment are needed to better understand both the mechanisms of tissue homeostasis and the pathomechanisms of human disease.

scholarly journals Nasser Rusan: Scoping out centrosomes

2017 ◽  
Vol 216 (12) ◽  
pp. 3889-3890
Author(s):  
Marie Anne O’Donnell
Keyword(s):  
Control Cell ◽  
Cell Behavior

Rusan investigates how centrosomes control cell behavior and differentiation during development.

scholarly journals Matrix nanotopography as a regulator of cell function

2012 ◽  
Vol 197 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Deok-Ho Kim ◽  
Paolo P. Provenzano ◽  
Chris L. Smith ◽  
Andre Levchenko
Keyword(s):  
Signal Transduction ◽  
Cell Function ◽  
Control Cell ◽  
Signal Transduction Pathways ◽  
Cell Behavior ◽  
Powerful Means ◽  
Cell Processes ◽  
Chemical Factors ◽  
Physical Interactions

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition to soluble chemical factors, physical interactions between the cell and ECM regulate primary cell processes, including differentiation, migration, and proliferation. Advances in microtechnology and, more recently, nanotechnology provide a powerful means to study the influence of the ECM on cell behavior. By recapitulating local architectures that cells encounter in vivo, we can elucidate and dissect the fundamental signal transduction pathways that control cell behavior in critical developmental, physiological, and pathological processes.

scholarly journals Liquid condensation drives telomere clustering during ALT

2019 ◽  
Author(s):  
Huaiying Zhang ◽  
Michel Liu ◽  
Robert Dilley ◽  
David M. Chenoweth ◽  
Roger A. Greenberg ◽  
...  
Keyword(s):  
Dna Repair ◽  
Chemical Composition ◽  
Cancer Cells ◽  
Material Properties ◽  
General Framework ◽  
Cellular Functions ◽  
Telomere Elongation ◽  
Alternative Lengthening ◽  
Chemically Induced ◽  
Chemically Induced Dimerization

AbstractTelomerase-free cancer cells employ a recombination-based alternative lengthening of telomeres (ALT) pathway that depends on ALT-associated promyelocytic leukemia (PML) nuclear bodies (APBs), whose function is unclear. We find that APBs behave as liquid condensates, suggesting two potential mechanisms to promote telomere elongation: condensation to enrich DNA repair factors for telomere synthesis and coalescence to cluster telomeres to provide repair templates. Using chemically-induced dimerization, we show that telomere sumoylation nucleates APB condensation via SUMO-SIM (SUMO interaction motif) interactions and clusters telomeres. The induced APBs lack DNA repair factors, indicating that these factors are clients recruited to the APB scaffold rather than components that drive condensation. Telomere clustering, however, relies only on liquid properties of the condensate, as an alternative condensation chemistry also induces clustering. Our results demonstrate how the material properties and chemical composition of APBs independently contribute to ALT, suggesting a general framework for how liquid condensates promote cellular functions.

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