scholarly journals Cell height: Tao rising

2012 ◽  
Vol 199 (7) ◽  
pp. 1023-1024 ◽  
Author(s):  
Liang Cai ◽  
Keith E. Mostov
Keyword(s):  
Drosophila Melanogaster ◽  
Cell Adhesion ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Lateral Surface ◽  
Cell Shape ◽  
Cell Adhesion Molecule ◽  
Follicular Epithelium ◽  
Shape Transition ◽  
Cell Height

During oogenesis in Drosophila melanogaster, the cells in the follicular epithelium of the ovary undergo a transition from a cuboidal to a squamous shape. In this issue, Gomez et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201207150) show that the kinase Tao promotes the endocytosis of the cell adhesion molecule Fasciclin 2 from the lateral surface of the cell and is critical for the cuboidal to squamous cell shape transition. Their results indicate that Tao is rising as a regulator of cell height.

Nerve cell adhesion molecule expression in squamous cell carcinoma of the head and neck: A predictor of propensity toward perineural spread

1999 ◽  
Vol 109 (5) ◽  
pp. 821-826 ◽  
Author(s):  
Robert B. McLaughlin ◽  
Kathleen T. Montone ◽  
Stephen J. Wall ◽  
Ara A. Chalian ◽  
Gregory S. Weinstein ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Nerve Cell ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Adhesion Molecule Expression ◽  
Perineural Spread

L1 cell adhesion molecule (L1CAM) in stage IB cervical cancer: distinct expression in squamous cell carcinomas and adenocarcinomas

2020 ◽  
Vol 73 (11) ◽  
pp. 748-753
Author(s):  
Joao Paulo Mancusi de Carvalho ◽  
Rafael C Salim ◽  
Filomena Marino Carvalho ◽  
Maria Luiza Nogueira Dias Genta ◽  
Edmund Chada Baracat ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Squamous Cell Carcinomas ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes ◽  
Disease Free ◽  
L1 Cell Adhesion Molecule ◽  
E Cadherin

AimsL1 cell adhesion molecule (L1CAM) has been shown to be correlated with tumour progression, attributed to its possible association with epithelial-mesenchymal transition (EMT), characterised by the expression of vimentin and loss of e-cadherin. Herein, we investigate the associations between L1CAM and clinicopathological parameters, as well as the expression of vimentin and e-cadherin, in carcinomas restricted to the cervix.MethodsThe study was retrospective observational and included 45 squamous cell carcinomas (63.4%) and 26 adenocarcinomas (36.6%) submitted to primary surgical treatment. Patient age, FIGO (International Federation of Gynecology and Obstetrics) stage, tumour size and follow-up were obtained from the medical records. All the slides were revised to evaluate histological differentiation, lymphovascular space invasion, depth of infiltration, disease-free cervical wall thickness, pattern of invasion front, Silva pattern (for adenocarcinomas) and the percentage of tumour-infiltrating lymphocytes. Tissue microarrays were constructed for immunohistochemical staining for L1CAM, e-cadherin and vimentin.ResultsAdenocarcinomas were associated with lower disease-free and overall survival. L1CAM and vimentin expressions were more frequent among adenocarcinomas, although loss of e-cadherin expression was more common among squamous carcinomas. L1CAM expression was associated with larger tumours, vimentin expression and lower disease-free survival. No association was observed between the expression of either L1CAM or vimentin and loss of e-cadherin. High levels of tumour-infiltrating lymphocytes were more frequent in squamous cell carcinoma, high-grade tumours, destructive pattern at front of invasion and loss of e-cadherin expression.ConclusionsOur results confirm the prognostic role of L1CAM in cervical carcinomas, but suggest a role for mechanisms other than EMT.

Activated leukocyte cell adhesion molecule (ALCAM/CD166) expression in head and neck squamous cell carcinoma (HNSSC)

2014 ◽  
Vol 210 (10) ◽  
pp. 649-655 ◽  
Author(s):  
Till Sebastian Clauditz ◽  
Kirsten von Rheinbaben ◽  
Patrick Lebok ◽  
Sarah Minner ◽  
Michael Tachezy ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neck Squamous Cell Carcinoma

scholarly journals Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure

2011 ◽  
Vol 192 (2) ◽  
pp. 335-348 ◽  
Author(s):  
Caroline Laplante ◽  
Laura A. Nilson
Keyword(s):  
Drosophila Melanogaster ◽  
Cell Adhesion ◽  
Actin Cytoskeleton ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Leading Edge ◽  
Scaffolding Protein ◽  
Asymmetric Distribution ◽  
Dorsal Closure ◽  
Dorsal Midline

During Drosophila melanogaster dorsal closure, lateral sheets of embryonic epidermis assemble an actomyosin cable at their leading edge and migrate dorsally over the amnioserosa, converging at the dorsal midline. We show that disappearance of the homophilic cell adhesion molecule Echinoid (Ed) from the amnioserosa just before dorsal closure eliminates homophilic interactions with the adjacent dorsal-most epidermal (DME) cells, which comprise the leading edge. The resulting planar polarized distribution of Ed in the DME cells is essential for the localized accumulation of actin regulators and for actomyosin cable formation at the leading edge and for the polarized localization of the scaffolding protein Bazooka/PAR-3. DME cells with uniform Ed fail to assemble a cable and protrude dorsally, suggesting that the cable restricts dorsal migration. The planar polarized distribution of Ed in the DME cells thus provides a spatial cue that polarizes the DME cell actin cytoskeleton, defining the epidermal leading edge and establishing its contractile properties.

Expression of the cell-cell adhesion molecule E-cadherin in squamous cell carcinoma of the head and neck

2007 ◽  
Vol 18 (3) ◽  
pp. 196-201 ◽  
Author(s):  
GAYLE L. BOWIE ◽  
A.W. CASLIN ◽  
N.J. ROLAND ◽  
J.K.K. MA. FIELD ◽  
A.S. JONES ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
E Cadherin ◽  
Cell Cell

scholarly journals Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 26192-26205 ◽  
Author(s):  
Marjolijn D. Trietsch ◽  
Maaike H.M. Oonk ◽  
Lukas J.A.C. Hawinkels ◽  
Rosalie Bor ◽  
Jaap D.H. van Eendenburg ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Prognostic Value ◽  
Cell Adhesion Molecule ◽  
Squamous Cell Carcinomas ◽  
Large Series ◽  
Clinicopathologic Characteristics ◽  
L1 Cell Adhesion Molecule
Sign in / Sign up

Export Citation Format

Share Document