scholarly journals Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 26192-26205 ◽  
Author(s):  
Marjolijn D. Trietsch ◽  
Maaike H.M. Oonk ◽  
Lukas J.A.C. Hawinkels ◽  
Rosalie Bor ◽  
Jaap D.H. van Eendenburg ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Prognostic Value ◽  
Cell Adhesion Molecule ◽  
Squamous Cell Carcinomas ◽  
Large Series ◽  
Clinicopathologic Characteristics ◽  
L1 Cell Adhesion Molecule

L1 cell adhesion molecule (L1CAM) in stage IB cervical cancer: distinct expression in squamous cell carcinomas and adenocarcinomas

2020 ◽  
Vol 73 (11) ◽  
pp. 748-753
Author(s):  
Joao Paulo Mancusi de Carvalho ◽  
Rafael C Salim ◽  
Filomena Marino Carvalho ◽  
Maria Luiza Nogueira Dias Genta ◽  
Edmund Chada Baracat ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Squamous Cell Carcinomas ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes ◽  
Disease Free ◽  
L1 Cell Adhesion Molecule ◽  
E Cadherin

AimsL1 cell adhesion molecule (L1CAM) has been shown to be correlated with tumour progression, attributed to its possible association with epithelial-mesenchymal transition (EMT), characterised by the expression of vimentin and loss of e-cadherin. Herein, we investigate the associations between L1CAM and clinicopathological parameters, as well as the expression of vimentin and e-cadherin, in carcinomas restricted to the cervix.MethodsThe study was retrospective observational and included 45 squamous cell carcinomas (63.4%) and 26 adenocarcinomas (36.6%) submitted to primary surgical treatment. Patient age, FIGO (International Federation of Gynecology and Obstetrics) stage, tumour size and follow-up were obtained from the medical records. All the slides were revised to evaluate histological differentiation, lymphovascular space invasion, depth of infiltration, disease-free cervical wall thickness, pattern of invasion front, Silva pattern (for adenocarcinomas) and the percentage of tumour-infiltrating lymphocytes. Tissue microarrays were constructed for immunohistochemical staining for L1CAM, e-cadherin and vimentin.ResultsAdenocarcinomas were associated with lower disease-free and overall survival. L1CAM and vimentin expressions were more frequent among adenocarcinomas, although loss of e-cadherin expression was more common among squamous carcinomas. L1CAM expression was associated with larger tumours, vimentin expression and lower disease-free survival. No association was observed between the expression of either L1CAM or vimentin and loss of e-cadherin. High levels of tumour-infiltrating lymphocytes were more frequent in squamous cell carcinoma, high-grade tumours, destructive pattern at front of invasion and loss of e-cadherin expression.ConclusionsOur results confirm the prognostic role of L1CAM in cervical carcinomas, but suggest a role for mechanisms other than EMT.

scholarly journals Semaphorin3D Regulates Axon Axon Interactions by Modulating Levels of L1 Cell Adhesion Molecule

2007 ◽  
Vol 27 (36) ◽  
pp. 9653-9663 ◽  
Author(s):  
M. A. Wolman ◽  
A. M. Regnery ◽  
T. Becker ◽  
C. G. Becker ◽  
M. C. Halloran
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
L1 Cell Adhesion Molecule
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