Synthesis, Spectral Studies, and Biological Activity of Metal Complexes of Benzofuran Thiosemicarbazides

2004 ◽  
Vol 34 (10) ◽  
pp. 1755-1768 ◽  
Author(s):  
M. B. Halli ◽  
Shashidhar ◽  
Z. S. Qureshi
Keyword(s):  
Biological Activity ◽  
Metal Complexes ◽  
Spectral Studies

scholarly journals Synthesis, Characterisation and Biological Activity of Thienoyl- and Furanoyl-Derived Schiff-Base Compounds With 3d Metal Ions

1998 ◽  
Vol 5 (6) ◽  
pp. 355-359
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Ions ◽  
Metal Complexes ◽  
Biological Properties ◽  
Spectral Studies

Cobalt(ll), copper(ll), nickel(ll) and zinc(ll) metal complexes of 2-carboxybenzylidene thienoylhydrazide HL1 and 2-carboxybenzylidene furenoylhydrazide HL2 of the type [M(L)2.Cl2] have been prepared where M = Co(ll) and Ni(ll) and L = HL1 and HL2 (Fig 1) and characterized by their physical, analytical and spectral studies. The different mode of chelation of the ligands with metals and the effect of these metals on their biological properties is discussed.

scholarly journals Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid

2020 ◽  
Vol 20 (6) ◽  
pp. 1311
Author(s):  
Shatha Mohammed Hassan Obaid ◽  
Jasim Shihab Sultan ◽  
Abbas Ali Salih Al-Hamdani
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Complexes ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Physical Analysis ◽  
Flame Atomic Absorption ◽  
Vis Spectroscopy ◽  
Ft Ir

The reaction of methyldopa with o-vanillin in refluxing ethanol afforded Schiff base and characterized through physical analysis with a number of spectra also the study of biological activity. The geometry of the Schiff base was identified through using (C.H.N) analysis, Mass, 1H-NMR, FT-IR, UV-Vis spectroscopy. Metal complexes of Cr3+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+ and Hg2+ with Schiff base have been prepared in the molar ratio 2:1 (Metal:L), (L = Schiff base ligand) except Hg2+ at molar ratio 1:1 (Hg:L). The prepared complexes were characterized by using Mass, FT-IR and UV-Vis spectral studies, on other than magnetic properties and flame atomic absorption, conductivity measurements. According to the results a dinuclear octahedral geometry has been suggested for Cr3+, Mn2+, Co2+, Ni2+, Cu2+ and Zn2+ complexes, dinuclear tetrahedral for Cd2+ and mononuclear tetrahedral for Hg2+ complex. This work highlights the relevance of metal complexation strategy to stabilize the ligands and improve their bioactivity. Schiff base complexes have been screen for their antibacterial activity against Gram negative and positive bacteria and antifungal activity showing promising antibacterial and biological activity.

scholarly journals Synthesis, Characterization, and Biological Activity of Some Transition Metal Complexes of N-Benzoyl-N′-2-thiophenethiocarbohydrazide

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Mahendra Yadav
Keyword(s):  
Magnetic Susceptibility ◽  
Biological Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Elemental Analysis ◽  
Spectral Studies ◽  
Antifungal Properties ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal

In the present study, Mn(II), Fe(II), Ni(II), and Cu(II) complexes of N-benzoyl -N′-2-thiophenethiocarbohydrazide (H2 BTTH) have been synthesized and characterized by elemental analysis, magnetic susceptibility measurements, infrared, NMR, electronic, and ESR spectral studies. The complexes were found to have compositions [Mn(H BTTH)2], [Ni(BTTH)(H2O)2], [Cu(BTTH)], and [Fe(H BTTH)2EtOH]. The antibacterial and antifungal properties of H2 BTTH and its metal complexes have been screened against several bacteria and fungi.

scholarly journals New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2288
Author(s):  
Ahmed Gaber ◽  
Moamen S. Refat ◽  
Arafa A.M. Belal ◽  
Ibrahim M. El-Deen ◽  
Nader Hassan ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Biological Activity ◽  
Molecular Docking ◽  
Metal Complexes ◽  
Analytical Data ◽  
Docking Study ◽  
Spectroscopic Techniques ◽  
Molecular Docking Study ◽  
Tetrahedral Geometry ◽  
Thiosemicarbazone Complexes

Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. The structure of the MTSC ligand and its metal complexes was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), and thermal differential analysis (DrTGA). The spectral and analytical data revealed that the obtained thiosemicarbazone-metal complexes have octahedral geometry around the metal center, except for the Zn2+-thiosemicarbazone complexes, which showed a tetrahedral geometry. The antibacterial and antifungal activities of the MTSC ligand and its (Co2+, Ni2+, Cu2+, and Zn2+) metal complexes were also investigated. Interestingly, the antibacterial activity of MTSC- metal complexes against examined bacteria was higher than that of the MTSC alone, which indicates that metal complexation improved the antibacterial activity of the parent ligand. Among different metal complexes, the MTSC- mono- and binuclear Cu2+ complexes showed significant antibacterial activity against Bacillus subtilis and Proteus vulgaris, better than that of the standard gentamycin drug. The in silico molecular docking study has revealed that the MTSC ligand could be a potential inhibitor for the oxidoreductase protein.

Structural characterization and biological activity of a new metal complexes based of Schiff base

2021 ◽  
Vol 330 ◽  
pp. 115522
Author(s):  
Ola A. El-Gammal ◽  
Farid Sh. Mohamed ◽  
Ghada N. Rezk ◽  
Ashraf A. El-Bindary
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Structural Characterization
Sign in / Sign up

Export Citation Format

Share Document