scholarly journals Synthesis, Characterisation and Biological Activity of Thienoyl- and Furanoyl-Derived Schiff-Base Compounds With 3d Metal Ions

1998 ◽  
Vol 5 (6) ◽  
pp. 355-359
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Ions ◽  
Metal Complexes ◽  
Biological Properties ◽  
Spectral Studies

Cobalt(ll), copper(ll), nickel(ll) and zinc(ll) metal complexes of 2-carboxybenzylidene thienoylhydrazide HL1 and 2-carboxybenzylidene furenoylhydrazide HL2 of the type [M(L)2.Cl2] have been prepared where M = Co(ll) and Ni(ll) and L = HL1 and HL2 (Fig 1) and characterized by their physical, analytical and spectral studies. The different mode of chelation of the ligands with metals and the effect of these metals on their biological properties is discussed.

scholarly journals Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid

2020 ◽  
Vol 20 (6) ◽  
pp. 1311
Author(s):  
Shatha Mohammed Hassan Obaid ◽  
Jasim Shihab Sultan ◽  
Abbas Ali Salih Al-Hamdani
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Complexes ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Physical Analysis ◽  
Flame Atomic Absorption ◽  
Vis Spectroscopy ◽  
Ft Ir

The reaction of methyldopa with o-vanillin in refluxing ethanol afforded Schiff base and characterized through physical analysis with a number of spectra also the study of biological activity. The geometry of the Schiff base was identified through using (C.H.N) analysis, Mass, 1H-NMR, FT-IR, UV-Vis spectroscopy. Metal complexes of Cr3+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+ and Hg2+ with Schiff base have been prepared in the molar ratio 2:1 (Metal:L), (L = Schiff base ligand) except Hg2+ at molar ratio 1:1 (Hg:L). The prepared complexes were characterized by using Mass, FT-IR and UV-Vis spectral studies, on other than magnetic properties and flame atomic absorption, conductivity measurements. According to the results a dinuclear octahedral geometry has been suggested for Cr3+, Mn2+, Co2+, Ni2+, Cu2+ and Zn2+ complexes, dinuclear tetrahedral for Cd2+ and mononuclear tetrahedral for Hg2+ complex. This work highlights the relevance of metal complexation strategy to stabilize the ligands and improve their bioactivity. Schiff base complexes have been screen for their antibacterial activity against Gram negative and positive bacteria and antifungal activity showing promising antibacterial and biological activity.

scholarly journals Synthesis, Characterization and Biological Activity of Transition Metal Complexes of [1-(2-bromo, 5-methoxy benzylidene) hydrazine] Ligand

2020 ◽  
Vol 10 (2) ◽  
pp. 2056-2062
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Antimalarial Activity ◽  
Spectroscopic Methods ◽  
The Novel

A series of metal complexes was synthesized from the novel Schiff base [1-(2-bromo-5-methoxybenzylidene)-hydrazine] ligand. The ligand and metal complexes were well characterized by spectroscopic methods. The ligand was found to be monodentate. Stoichiometry of the ligand to metal ions was confirmed to be 4:1. Furthermore, the synthesized metal complexes were screened for antimicrobial, antitubercular, and antimalarial activities, which revealed that Cu (II) and Zn (II) showed excellent antimicrobial activity, Ni (II) was active against M. Tuberculosis, and Cd (II) showed excellent antimalarial activity.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

Structural characterization and biological activity of a new metal complexes based of Schiff base

2021 ◽  
Vol 330 ◽  
pp. 115522
Author(s):  
Ola A. El-Gammal ◽  
Farid Sh. Mohamed ◽  
Ghada N. Rezk ◽  
Ashraf A. El-Bindary
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Structural Characterization
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