Effect of Boo Yong‐Tang on Mast Cell‐Mediated Allergic Reaction

2004 ◽  
Vol 26 (3) ◽  
pp. 445-454 ◽  
Author(s):  
Ho‐Jeong Na ◽  
Hyun‐Ja Jeong ◽  
Seung‐Heon Hong ◽  
Chung‐Yeon Hwang ◽  
Wung‐Suk Cha ◽  
...  
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2016 ◽  
Vol 38 (1) ◽  
pp. 90-99 ◽  
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Yeon-Yong Kim ◽  
In-Gyu Je ◽  
Min Jong Kim ◽  
Byeong-Cheol Kang ◽  
Young-Ae Choi ◽  
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2011 ◽  
Vol 32 (1) ◽  
pp. 43-48 ◽  
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Monika Jedrzejczak-Czechowicz ◽  
Anna Lewandowska-Polak ◽  
Marzanna Jarzebska ◽  
Marek L. Kowalski

2018 ◽  
Vol 19 (12) ◽  
pp. 4092 ◽  
Author(s):  
Chen Shao ◽  
Bingjie Fu ◽  
Ning Ji ◽  
Shunli Pan ◽  
Xiaoxia Zhao ◽  
...  

Alisol B 23-acetate (AB23A), a natural triterpenoid, has been reported to exert hepatoprotective and antitumor activities. Aiming to investigate the anti-inflammatory activity, this study examined the effect of AB23A on mast cells and allergic reaction. AB23A inhibited the degranulation of mast cells stimulated by immunoglobulin E/antigen (IgE/Ag), and also decreased the synthesis of leukotriene C4 (LTC4), production of interlukin-6 (IL-6), and expression of cyclooxygenase-2 (COX-2) in a concentration-dependent manner with no significant cytotoxicity in bone marrow-derived mast cells (BMMCs). AB23A inhibited spleen tyrosine kinase (Syk) and the downstream signaling molecules including phospholipase Cγ (PLCγ), serine-threonine protein kinase/inhibitor of nuclear factor kappa-B kinase/nuclear factor kappa-B (Akt/IKK/NF-κB), and mitogen-activated protein kinases/cytosolic phospholipase A2 (MAPK/cPLA2). Furthermore, AB23A blocked mobilization of Ca2+. Similar results were obtained in other mast cell lines Rat basophilic leukemia (RBL)-2H3 cells and a human mast cell line (HMC-1). In addition, AB23A attenuated allergic responses in an acute allergy animal model, passive cutaneous anaphylaxis (PCA). Taken together, this study suggests that AB23A inhibits the activation of mast cells and ameliorates allergic reaction, and may become a lead compound for the treatment of mast cell-mediated allergic diseases.


2012 ◽  
Vol 143 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Yue Lu ◽  
Ying Li ◽  
Meihua Jin ◽  
Ju Hye Yang ◽  
Xian Li ◽  
...  

2013 ◽  
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pp. 287-293 ◽  
Author(s):  
Ju Dong Kim ◽  
Do Kyun Kim ◽  
Hyuk Soon Kim ◽  
A-Ram Kim ◽  
Bokyung Kim ◽  
...  

2013 ◽  
Vol 86 (12) ◽  
pp. 1731-1738 ◽  
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Yoshikazu Inoh ◽  
Satoshi Tadokoro ◽  
Hiroki Tanabe ◽  
Makoto Inoue ◽  
Naohide Hirashima ◽  
...  

2007 ◽  
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pp. 783-790 ◽  
Author(s):  
Frederico Azevedo Costa-Pinto ◽  
Alexandre Salgado Basso ◽  
Momtchilo Russo

2007 ◽  
Vol 45 (11) ◽  
pp. 2138-2144 ◽  
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Sang-Hyun Kim ◽  
Soyoung Lee ◽  
In Kyeom Kim ◽  
Taeg Kyu Kwon ◽  
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...  
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2020 ◽  
Vol 69 (2) ◽  
pp. 296-299 ◽  
Author(s):  
Yuki Nakamura ◽  
Kayoko Ishimaru ◽  
Atsuhito Nakao

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