scholarly journals 2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway

2016 ◽  
Vol 38 (1) ◽  
pp. 90-99 ◽  
Author(s):  
Yeon-Yong Kim ◽  
In-Gyu Je ◽  
Min Jong Kim ◽  
Byeong-Cheol Kang ◽  
Young-Ae Choi ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Reaction ◽  
Signaling Pathway ◽  
Methoxybenzoic Acid

scholarly journals Pseudo-allergic reaction caused by Qingkailing injection partially via the PI3K-Rac1 signaling pathway in RBL-2H3 cells

2019 ◽  
Vol 8 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Qin Li ◽  
Lingxi Zhang ◽  
Lili Gu ◽  
Bo Zhang ◽  
Jiaqi Lu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Allergic Reaction ◽  
Signaling Pathway ◽  
Qingkailing Injection

Qingkailing injection (QKLI) is a kind of multi-component traditional Chinese medicine injection.

Mast cell and eosinophil activation during early phase of grass pollen‐induced ocular allergic reaction

2011 ◽  
Vol 32 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Monika Jedrzejczak-Czechowicz ◽  
Anna Lewandowska-Polak ◽  
Marzanna Jarzebska ◽  
Marek L. Kowalski
Keyword(s):  
Mast Cell ◽  
Allergic Reaction ◽  
Grass Pollen ◽  
Early Phase ◽  
Eosinophil Activation ◽  
Ocular Allergic Reaction

scholarly journals Alisol B 23-Acetate Inhibits IgE/Ag-Mediated Mast Cell Activation and Allergic Reaction

2018 ◽  
Vol 19 (12) ◽  
pp. 4092 ◽  
Author(s):  
Chen Shao ◽  
Bingjie Fu ◽  
Ning Ji ◽  
Shunli Pan ◽  
Xiaoxia Zhao ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Allergic Reaction ◽  
Nuclear Factor Kappa B ◽  
Immunoglobulin E ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
Dependent Manner ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

Alisol B 23-acetate (AB23A), a natural triterpenoid, has been reported to exert hepatoprotective and antitumor activities. Aiming to investigate the anti-inflammatory activity, this study examined the effect of AB23A on mast cells and allergic reaction. AB23A inhibited the degranulation of mast cells stimulated by immunoglobulin E/antigen (IgE/Ag), and also decreased the synthesis of leukotriene C4 (LTC4), production of interlukin-6 (IL-6), and expression of cyclooxygenase-2 (COX-2) in a concentration-dependent manner with no significant cytotoxicity in bone marrow-derived mast cells (BMMCs). AB23A inhibited spleen tyrosine kinase (Syk) and the downstream signaling molecules including phospholipase Cγ (PLCγ), serine-threonine protein kinase/inhibitor of nuclear factor kappa-B kinase/nuclear factor kappa-B (Akt/IKK/NF-κB), and mitogen-activated protein kinases/cytosolic phospholipase A2 (MAPK/cPLA2). Furthermore, AB23A blocked mobilization of Ca2+. Similar results were obtained in other mast cell lines Rat basophilic leukemia (RBL)-2H3 cells and a human mast cell line (HMC-1). In addition, AB23A attenuated allergic responses in an acute allergy animal model, passive cutaneous anaphylaxis (PCA). Taken together, this study suggests that AB23A inhibits the activation of mast cells and ameliorates allergic reaction, and may become a lead compound for the treatment of mast cell-mediated allergic diseases.

Paeoniflorin inhibits MRGPRX2‐mediated pseudo‐allergic reaction via calcium signaling pathway

2019 ◽  
Vol 34 (2) ◽  
pp. 401-408
Author(s):  
Jianli Wang ◽  
Yongjing Zhang ◽  
Jue Wang ◽  
Rui Liu ◽  
Guiping Zhang ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Calcium Signaling ◽  
Signaling Pathway ◽  
Calcium Signaling Pathway

Effect of Boo Yong‐Tang on Mast Cell‐Mediated Allergic Reaction

2004 ◽  
Vol 26 (3) ◽  
pp. 445-454 ◽  
Author(s):  
Ho‐Jeong Na ◽  
Hyun‐Ja Jeong ◽  
Seung‐Heon Hong ◽  
Chung‐Yeon Hwang ◽  
Wung‐Suk Cha ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Reaction

Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation

2012 ◽  
Vol 143 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Yue Lu ◽  
Ying Li ◽  
Meihua Jin ◽  
Ju Hye Yang ◽  
Xian Li ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Reaction ◽  
Cell Activation ◽  
Mast Cell Activation
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