DNAase I Hypersensitive Site 3' to the β-Globin Gene Cluster Containing Two TAA Insertions and a G→A Polymorphism is Predominantly Associated with the β -Thalassemia IVS-I-6 (T→C) Mutation

Hemoglobin ◽  
2005 ◽  
Vol 29 (1) ◽  
pp. 85-89
Author(s):  
Juliana Martins ◽  
Silvana Bordin ◽  
Dulcinéia de Albuquerque ◽  
Sara Saad ◽  
Fernando Costa
Keyword(s):  
Gene Cluster ◽  
Globin Gene ◽  
Hypersensitive Site ◽  
Globin Gene Cluster

High-mobility group protein 2 may be involved in the locus control region regulation of the β-globin gene cluster

2002 ◽  
Vol 80 (6) ◽  
pp. 765-770
Author(s):  
Xiang Lv ◽  
Dong-dong Xu ◽  
De-pei Liu ◽  
Lei Li ◽  
De-long Hao ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Control Region ◽  
Globin Gene ◽  
High Mobility ◽  
Locus Control Region ◽  
High Mobility Group ◽  
Hypersensitive Site ◽  
High Mobility Group Protein ◽  
Globin Gene Cluster ◽  
Group Protein

Expression regulation of the β-globin gene cluster is a result of synergistic interactions between cis-elements and trans-acting factors. Previous studies usually concentrated on the core sequence of each hypersensitive site in the locus control region of the β-globin gene cluster. But more and more evidence illustrates that the flanking regions are indispensable also. Using electrophoretic mobility shift assay and solid-phase DNase I footprinting methods, we identified a small nuclear protein from K562 cells that binds specifically to the first AT-rich region flanking the hypersensitive site 2 core sequence of the human β-globin gene locus control region. N-terminal sequencing of the enriched protein proved that it is a member of the high-mobility group protein 2 family. This indicates that the AT-rich region in human hypersensitive site 2 may take part in the regulation of the β-globin gene cluster by facilitating DNA bending, which is a prerequisite for the looping mechanism in this region.Key words: β-globin gene, locus control region, hypersensitive site 2, AT-rich region, high-mobility group protein 2.

DNAase I Hypersensitive Site 3′ to the β-Globin Gene Cluster Containing Two TAA Insertions and a G→A Polymorphism is Predominantly Associated with the β+-Thalassemia IVS-I-6 (T→C) Mutation

Hemoglobin ◽  
2005 ◽  
Vol 29 (1) ◽  
pp. 85-89
Author(s):  
Juliana T. N Martins ◽  
Silvana Bordin ◽  
Dulcinéia M. de Albuquerque ◽  
Sara T. O Saad ◽  
Fernando F. Costa
Keyword(s):  
Gene Cluster ◽  
Globin Gene ◽  
Hypersensitive Site ◽  
Globin Gene Cluster

Rapid and reliable β-globin gene cluster haplotyping of sickle cell disease patients by FRET Light Cycler and HRM assays

2011 ◽  
Vol 412 (13-14) ◽  
pp. 1257-1261 ◽  
Author(s):  
Philippe Joly ◽  
Philippe Lacan ◽  
Caroline Garcia ◽  
Angelique Delasaux ◽  
Alain Francina
Keyword(s):  
Sickle Cell Disease ◽  
Gene Cluster ◽  
Sickle Cell ◽  
Globin Gene ◽  
Cell Disease ◽  
Globin Gene Cluster ◽  
Light Cycler

Hemoglobin variants, hematological parameters andβ-globin gene cluster haplotypes in an isolated Amerindian group from the Orinoco River Delta

2008 ◽  
Vol 35 (2) ◽  
pp. 250-255 ◽  
Author(s):  
Anabel Arends ◽  
Marycarmen Chacín ◽  
Martha Bravo-Urquiola ◽  
Tibisay Arends De O ◽  
Maritza Álvarez ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Hematological Parameters ◽  
Globin Gene ◽  
River Delta ◽  
Orinoco River ◽  
Globin Gene Cluster ◽  
Hemoglobin Variants

scholarly journals Variants of ZBTB7A (LRF) and its β-globin gene cluster binding motifs in sickle cell anemia

2016 ◽  
Vol 59 ◽  
pp. 49-51 ◽  
Author(s):  
Elmutaz M. Shaikho ◽  
Alawi H. Habara ◽  
Abdulrahman Alsultan ◽  
A.M. Al-Rubaish ◽  
Fahad Al-Muhanna ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Globin Gene ◽  
Binding Motifs ◽  
Globin Gene Cluster

Comparison of theα-globin gene cluster structure in Perissodactyla

1990 ◽  
Vol 30 (1) ◽  
pp. 36-42 ◽  
Author(s):  
J. Flint ◽  
O. A. Ryder ◽  
J. B. Clegg
Keyword(s):  
Gene Cluster ◽  
Globin Gene ◽  
Cluster Structure ◽  
Globin Gene Cluster

Molecular Rearrangements of the Human ?-Globin Gene Cluster

1985 ◽  
Vol 445 (1 Fifth Cooley') ◽  
pp. 45-56 ◽  
Author(s):  
D. R. HIGGS ◽  
A. V. S. HILL ◽  
R. NICHOLLS ◽  
S. E. Y. GOODBOURN ◽  
H. AYYUB ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Globin Gene ◽  
Molecular Rearrangements ◽  
Globin Gene Cluster

Beta-Globin Gene Cluster Haplotypes of Amerindian Populations from the Brazilian Amazon Region

1994 ◽  
Vol 44 (3) ◽  
pp. 142-149 ◽  
Author(s):  
João Farias Guerreiro ◽  
Mauro Silvério Figueiredo ◽  
Marco Antonio Zago
Keyword(s):  
Gene Cluster ◽  
Globin Gene ◽  
Brazilian Amazon ◽  
Amazon Region ◽  
Beta Globin ◽  
Beta Globin Gene ◽  
Globin Gene Cluster ◽  
Brazilian Amazon Region

scholarly journals Z-DNA-forming sites within the human beta-globin gene cluster.

1996 ◽  
Vol 93 (2) ◽  
pp. 780-784 ◽  
Author(s):  
V. Muller ◽  
M. Takeya ◽  
S. Brendel ◽  
B. Wittig ◽  
A. Rich
Keyword(s):  
Gene Cluster ◽  
Globin Gene ◽  
Beta Globin ◽  
Beta Globin Gene ◽  
Globin Gene Cluster ◽  
Z Dna
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