Stimulation of RANKL and Inhibition of Membrane‐Type Matrix Metalloproteinase‐1 Expression by Parathyroid Hormone in Normal Human Osteoblasts

2004 ◽  
Vol 30 (3) ◽  
pp. 369-377 ◽  
Author(s):  
Li‐Juan Guo ◽  
Hui Xie ◽  
Hou‐De Zhou ◽  
Xiang‐Hang Luo ◽  
Yi‐Qun Peng ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Matrix Metalloproteinase ◽  
Human Osteoblasts ◽  
Matrix Metalloproteinase 1 ◽  
Normal Human ◽  
Membrane Type ◽  
Stimulation Of

Abstract 172: Lumican-null Mice Are Susceptible to Aging and Isoproterenol-induced Myocardial Fibrosis

2014 ◽  
Vol 115 (suppl_1) ◽  
Author(s):  
Pao-Hsien Chu
Keyword(s):  
Matrix Metalloproteinase ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Myocardial Fibrosis ◽  
Cardiac Remodeling ◽  
Cardiac Fibrosis ◽  
Systolic Function ◽  
Wild Type ◽  
Matrix Metalloproteinase 1 ◽  
Membrane Type

Aims: With aging and stresses, the myocardium undergoes structural remodeling and often leading to fibrosis. Main Methods: To examine whether lumican, one of the class II small leucine-rich proteoglycans, has a role in cardiac remodeling and fibrosis, we analyzed the basic cardiac phenotypes of lumican-null (Lum-/-) mice in both youth and elder, and then used the isoproterenol-induced cardiac fibrosis model to study the roles of extra-cellular matrix and apoptosis in cardiac remodeling. Key Findings: Higher mortality resulted from significantly impaired systolic function, and an increase of atrial natriuretic peptide secreted by the ventricles in response to excessive stretching of myocytes of Lum-/- mice in comparison to wild type littermates. In addition, Lum-/- mice exhibited higher level of TGF-β, collagen I/III, and membrane-type matrix metalloproteinase-1 (MT1-MMP, or MMP-14) during cardiac remodeling. Significance: Our data implicates that the lumican protein plays an important role in the pathogenesis of cardiac fibrosis.

scholarly journals Membrane-type matrix metalloproteinase-1(MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomas

1998 ◽  
Vol 28 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Tomika Harada ◽  
Shigeki Arii ◽  
Masahiro Mise ◽  
Takashi Imamura ◽  
Hiroaki Higashitsuji ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Hepatocellular Carcinomas ◽  
Matrix Metalloproteinase 1 ◽  
Membrane Type

Equine laminitis: Membrane type matrix metalloproteinase-1 (MMP-14) is involved in acute phase onset

2008 ◽  
Vol 40 (5) ◽  
pp. 482-487 ◽  
Author(s):  
M. T. Kyaw-Tanner ◽  
O. Wattle ◽  
A. W. Eps ◽  
C. C. Pollitt
Keyword(s):  
Matrix Metalloproteinase ◽  
Acute Phase ◽  
Matrix Metalloproteinase 1 ◽  
Membrane Type

Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP)

2005 ◽  
Vol 38 (1) ◽  
pp. 43-46 ◽  
Author(s):  
Kazuharu Irie ◽  
Kiyoshi Komori ◽  
Motoharu Seiki ◽  
Eichi Tsuruga ◽  
Yasunori Sakakura ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 1 ◽  
Membrane Type
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