Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Improving In Vitro Dissolution and Oral Absorption of Pueraria Lobata Isoflavone

2005 ◽  
Vol 31 (4-5) ◽  
pp. 349-356 ◽  
Author(s):  
Shengmiao Cui ◽  
Chunshun Zhao ◽  
Dawei Chen ◽  
Zhonggui He
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Absorption ◽  
Delivery Systems ◽  
In Vitro Dissolution ◽  
Pueraria Lobata

scholarly journals Predicting Oral Absorption of fenofibrate in Lipid-Based Drug Delivery Systems by Combining In Vitro Lipolysis with the Mucus-PVPA Permeability Model

2021 ◽  
Vol 110 (1) ◽  
pp. 208-216
Author(s):  
Margherita Falavigna ◽  
Mette Klitgaard ◽  
Ragna Berthelsen ◽  
Anette Müllertz ◽  
Gøril Eide Flaten
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Absorption ◽  
Delivery Systems ◽  
Permeability Model ◽  
In Vitro Lipolysis

Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

2020 ◽  
Vol 317 ◽  
pp. 375-384 ◽  
Author(s):  
Thuy Tran ◽  
Peter Bønløkke ◽  
Cristina Rodríguez-Rodríguez ◽  
Zeynab Nosrati ◽  
Pedro Luis Esquinas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vivo Imaging ◽  
Drug Delivery Systems ◽  
Oral Absorption ◽  
Delivery Systems ◽  
In Vitro Lipolysis

scholarly journals An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

2020 ◽  
Vol 149 ◽  
pp. 21-29 ◽  
Author(s):  
Caroline Alvebratt ◽  
Janneke Keemink ◽  
Khadijah Edueng ◽  
Ocean Cheung ◽  
Maria Strømme ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vitro Dissolution

scholarly journals Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations

Materials ◽  
2020 ◽  
Vol 13 (2) ◽  
pp. 329 ◽  
Author(s):  
Daria Lovskaya ◽  
Natalia Menshutina
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Amorphous State ◽  
Supercritical Drying ◽  
Delivery Systems ◽  
In Vitro Dissolution ◽  
Supercritical Adsorption ◽  
The Stability ◽  
Active Substances

The present work focuses on the preparation of alginate-based aerogels in the form of particles for their further study as potential drug delivery systems (solid dosage forms). The dripping method was used to prepare certain gel particles, and supercritical drying was used to obtain final alginate-based aerogel particles. Three model active substances (ketoprofen, nimesulide, loratadine) were impregnated into the obtained aerogels using the supercritical adsorption process. Using the method of X-ray analysis, it was shown that the in the obtained drug-loaded aerogels the corresponding active substances are in an amorphous state, and the stability of this state after six months of storage is confirmed. In vitro dissolution tests for obtained drug-loaded aerogels was performed. For each sample, an appropriate dissolution medium (with certain pH) was determined. In vitro investigations showed the increasing of the release rate for all model active substances. Time was required to release and dissolve 50% of the active drug from drug-loaded aerogels (T1/2), reduced in comparison with pure active drugs in crystalline form. Obtained results provide insight into the application of alginate-based aerogel particles as a drug delivery system to improve pharmacokinetic properties of certain active drugs.

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