Development of an in vitro dissolution method using microdialysis sampling technique for implantable drug delivery systems

1999 ◽  
Vol 88 (10) ◽  
pp. 1036-1040 ◽  
Author(s):  
Alekha K. Dash ◽  
Paul W. Haney ◽  
Marc J. Garavalia
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Sampling Technique ◽  
Delivery Systems ◽  
In Vitro Dissolution ◽  
Microdialysis Sampling ◽  
Dissolution Method ◽  
Implantable Drug Delivery Systems

scholarly journals An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

2020 ◽  
Vol 149 ◽  
pp. 21-29 ◽  
Author(s):  
Caroline Alvebratt ◽  
Janneke Keemink ◽  
Khadijah Edueng ◽  
Ocean Cheung ◽  
Maria Strømme ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vitro Dissolution

scholarly journals In Vitro Tests of FDM 3D-Printed Diclofenac Sodium-Containing Implants

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5889
Author(s):  
Petra Arany ◽  
Ildikó Papp ◽  
Marianna Zichar ◽  
Máté Csontos ◽  
János Elek ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Fused Deposition Modeling ◽  
Delivery Systems ◽  
In Vitro Tests ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Implantable Drug Delivery Systems

One of the most promising emerging innovations in personalized medication is based on 3D printing technology. For use as authorized medications, 3D-printed products require different in vitro tests, including dissolution and biocompatibility investigations. Our objective was to manufacture implantable drug delivery systems using fused deposition modeling, and in vitro tests were performed for the assessment of these products. Polylactic acid, antibacterial polylactic acid, polyethylene terephthalate glycol, and poly(methyl methacrylate) filaments were selected, and samples with 16, 19, or 22 mm diameters and 0%, 5%, 10%, or 15% infill percentages were produced. The dissolution test was performed by a USP dissolution apparatus 1. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide dye (MTT)-based prolonged cytotoxicity test was performed on Caco-2 cells to certify the cytocompatibility properties. The implantable drug delivery systems were characterized by thermogravimetric and heatflow assay, contact angle measurement, scanning electron microscopy, microcomputed tomography, and Raman spectroscopy. Based on our results, it can be stated that the samples are considered nontoxic. The dissolution profiles are influenced by the material properties of the polymers, the diameter, and the infill percentage. Our results confirm the potential of fused deposition modeling (FDM) 3D printing for the manufacturing of different implantable drug delivery systems in personalized medicine and may be applied during surgical interventions.

scholarly journals Alginate-Based Aerogel Particles as Drug Delivery Systems: Investigation of the Supercritical Adsorption and In Vitro Evaluations

Materials ◽  
2020 ◽  
Vol 13 (2) ◽  
pp. 329 ◽  
Author(s):  
Daria Lovskaya ◽  
Natalia Menshutina
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Amorphous State ◽  
Supercritical Drying ◽  
Delivery Systems ◽  
In Vitro Dissolution ◽  
Supercritical Adsorption ◽  
The Stability ◽  
Active Substances

The present work focuses on the preparation of alginate-based aerogels in the form of particles for their further study as potential drug delivery systems (solid dosage forms). The dripping method was used to prepare certain gel particles, and supercritical drying was used to obtain final alginate-based aerogel particles. Three model active substances (ketoprofen, nimesulide, loratadine) were impregnated into the obtained aerogels using the supercritical adsorption process. Using the method of X-ray analysis, it was shown that the in the obtained drug-loaded aerogels the corresponding active substances are in an amorphous state, and the stability of this state after six months of storage is confirmed. In vitro dissolution tests for obtained drug-loaded aerogels was performed. For each sample, an appropriate dissolution medium (with certain pH) was determined. In vitro investigations showed the increasing of the release rate for all model active substances. Time was required to release and dissolve 50% of the active drug from drug-loaded aerogels (T1/2), reduced in comparison with pure active drugs in crystalline form. Obtained results provide insight into the application of alginate-based aerogel particles as a drug delivery system to improve pharmacokinetic properties of certain active drugs.

An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems

2018 ◽  
Vol 147 ◽  
pp. 350-366 ◽  
Author(s):  
Mario Jug ◽  
Anita Hafner ◽  
Jasmina Lovrić ◽  
Maja Lusina Kregar ◽  
Ivan Pepić ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vitro Dissolution ◽  
Mucosal Drug Delivery
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