Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate

2003 ◽  
Vol 22 (1) ◽  
pp. 1-108
Keyword(s):  
Salicylic Acid ◽  
Methyl Salicylate ◽  
Safety Assessment ◽  
Sodium Salicylate ◽  
Alkyl Salicylate

scholarly journals Particle Properties of Spray-Dried and Agglomerated Products of Salicylic Acid and Sodium Salicylate

1972 ◽  
Vol 21 (225) ◽  
pp. 557-561
Author(s):  
Yoshiaki KAWASHIMA ◽  
Keiichi MATSUDA ◽  
Yoshiharu YASUE ◽  
Hideo TAKENAKA
Keyword(s):  
Salicylic Acid ◽  
Sodium Salicylate ◽  
Particle Properties ◽  
Spray Dried

Serum Concentrations of Salicylic Acid following Topically Applied Salicylate Derivatives

1996 ◽  
Vol 30 (9) ◽  
pp. 935-940 ◽  
Author(s):  
Pina Morra ◽  
William R Bartle ◽  
Scott E Walker ◽  
S Nicole Lee ◽  
Susan K Bowles ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Rate Constant ◽  
Maximum Concentration ◽  
Methyl Salicylate ◽  
Absorption Rate ◽  
The Other ◽  
Pharmacokinetic Parameters ◽  
Absorption Rate Constant ◽  
Serum Concentrations ◽  
Women Volunteers

OBJECTIVE: To compare the rate and extent of systemic salicylate absorption following single and multiple applications of two topically applied analgesics, one containing methyl salicylate and the other containing trolamine salicylate. DESIGN: Two-period, two-treatment, randomized, crossover, multiple-dose study in healthy men and women volunteers. PARTICIPANTS: Six men and six women volunteers, 21–14 years of age. INTERVENTIONS: Subjects applied 5 g of an ointment containing 12.5% methyl salicylate twice daily for 4 days (8 doses) or a cream containing trolamine 10% twice daily for two doses, to a 10-cm2 area on the thigh. Treatment order and leg (right or left) were assigned randomly. Subjects were crossed over to the alternate treatment on the other leg after a minimum washout period of 7 days. MAIN OUTCOME MEASURES: The total amount of salicylate recovered in the urine during two dosing intervals (24 hours) on each study day, relative to the applied dose, was used to calculate the bioavailability of each product. Mean standard pharmacokinetic parameters including area under the curve, maximum concentration (Cmax), time to maximum concentration, and minimum concentrations at steady-state were determined from serum concentrations. Serum concentrations were fit to three pharmacokinetic models and the suitability of each model was evaluated. Estimates of absorption rate constant, clearance, volume, and fraction absorbed on day 1 were estimated by using the best-fitting model. RESULTS: Salicylic acid could not be detected in serum after trolamine application. However, concentrations between 0.31 and 0.91 mg/L were detected within 1 hour of the first application of methyl salicylate and Cmax, between 2 and 6 mg/L were observed following the seventh application on day 4. Both the extent and rate of absorption changed after the first 24 hours. The absorption rate constant increased significantly from the first to the seventh dose (first dose absorption rate constant: 0.16 h−1; seventh dose: 0.28 h−1; p < 0.035). Urinary recovery of total salicylate (salicylic acid and principal metabolites of salicylic acid) during the first 24 hours of the methyl salicylate phase averaged 175.2 mg, exceeding the 6.9 mg (p < 0.05) recovered during the trolamine phase. The recovery of salicylate in the urine in the first 24 hours after application of methyl salicylate was significantly greater than the 1.4% recovered after application of trolamine (p < 0.05). Furthermore, the fraction of methyl salicylate recovered in the urine increased significantly from 15.5% on day 1 to approximately 22% on the second, third, and fourth days. CONCLUSIONS: A considerable amount of salicylic acid may be absorbed through the skin after topical application of methyl salicylate products and this may increase with multiple applications. Caution is warranted in patients for whom systemic salicylate may be hazardous or problematic.

Infrared spectra of hydrogen-bonded salicylic acid and its derivatives. Methyl salicylate

1985 ◽  
Vol 63 (6) ◽  
pp. 1344-1344
Author(s):  
Marek J. Wójcik ◽  
Czeslawa Paluszkiewicz
Keyword(s):  
Salicylic Acid ◽  
Infrared Spectra ◽  
Methyl Salicylate ◽  
Hydrogen Bonded

not available

Phenolic-type stabilizers as generators and quenchers of singlet molecular oxygen . Part I: methyl salicylate, salicylic acid and some related compounds

1995 ◽  
Vol 49 (3) ◽  
pp. 371-378 ◽  
Author(s):  
Arnaldo T. Soltermann ◽  
Daniel de la Peña ◽  
Santiago Nonell ◽  
Francisco Amat-Guerri ◽  
Norman A. García
Keyword(s):  
Salicylic Acid ◽  
Molecular Oxygen ◽  
Methyl Salicylate ◽  
Singlet Molecular Oxygen ◽  
Related Compounds

scholarly journals Use of a Synthetic Salicylic Acid Analog to Investigate the Roles of Methyl Salicylate and Its Esterases in Plant Disease Resistance

2009 ◽  
Vol 284 (11) ◽  
pp. 7307-7317 ◽  
Author(s):  
Sang-Wook Park ◽  
Po-Pu Liu ◽  
Farhad Forouhar ◽  
A. Corina Vlot ◽  
Liang Tong ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Disease Resistance ◽  
Plant Disease Resistance ◽  
Methyl Salicylate ◽  
Plant Disease ◽  
Acid Analog
Sign in / Sign up

Export Citation Format

Share Document