Expression of Heat-Shock Protein 25 Immunoreactivity in the Dental Pulp and Enamel Organ During Odontogenesis in the Rat Molar

2002 ◽  
Vol 43 (2) ◽  
pp. 220-223 ◽  
Author(s):  
Hayato Ohshima ◽  
Kuniko Nakakura-Ohshima ◽  
Takeyasu Maeda
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Dental Pulp ◽  
Enamel Organ ◽  
Rat Molar

scholarly journals Possible Role of Heat Shock Protein (Hsp) 25 in the Enamel Organ during Amelogenesis in the Rat Molar.

2001 ◽  
Vol 64 (4) ◽  
pp. 369-378 ◽  
Author(s):  
Yumiko OTSUKA ◽  
Kuniko NAKAKURA-OHSHIMA ◽  
Tadashi NODA ◽  
Takeyasu MAEDA ◽  
Hayato OHSHIMA
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Enamel Organ ◽  
Rat Molar

scholarly journals Transient Expression of Heat Shock Protein (Hsp) 25 in the Dental Pulp and Enamel Organ during Odontogenesis in the Rat Incisor.

2000 ◽  
Vol 63 (4) ◽  
pp. 381-395 ◽  
Author(s):  
Hayato OHSHIMA ◽  
Hisao AJIMA ◽  
Yoshiro KAWANO ◽  
Kayoko NOZAWA-INOUE ◽  
Satoshi WAKISAKA ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Transient Expression ◽  
Dental Pulp ◽  
Enamel Organ ◽  
Rat Incisor

Promotion of the Differentiation of Dental Pulp Stem Cells into Oligodendrocytes by Knockdown of Heat-Shock Protein 27

2022 ◽  
Author(s):  
Shu-Lin Guo ◽  
Chih-Hui Chin ◽  
Chi-Jung Huang ◽  
Chih-Cheng Chien ◽  
Yih-Jing Lee
Keyword(s):  
Stem Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Neurodegenerative Diseases ◽  
Dental Pulp ◽  
Potential Application ◽  
Neural Differentiation ◽  
Heat Shock Protein 27 ◽  
Dental Pulp Stem Cells ◽  
Immunofluorescent Staining

Stem cell-based therapy has been evaluated in many different clinical trials for various diseases. This capability was applied in various neurodegenerative diseases, such as Alzheimer’s disease, which is characterized by synaptic damage accompanied by neuronal loss. Dental pulp stem cells (DPSCs) are mesenchymal stem cells from the oral cavity and have been studied with potential application for regeneration of different tissues. Heat shock protein 27 (HSP27) is known to regulate neurogenesis in the process of neural differentiation of placenta-multipotent stem cells. Here, we hypothesize that HSP27 expression is also critical in neural differentiation of DPSCs. An evaluation of the possible role of HSP27 in differentiation of DPSCs was per-formed by gene knockdown and neural immunofluorescent staining. We found that HSP27 has a role in the differentiation of DPSCs and that knockdown of HSP27 in DPSCs renders cells to oligodendrocyte progenitors. In other words, shHSP27-DPSCs showed NG2-positive immunoreactivity and gave rise to oligodendrocytes or type-2 astrocytes. This neural differentiation of DPSCs may have clinical significance for treatment of patients with neurodegenerative diseases. In conclusion, our data provide an example of oligodendrocyte differentiation of a DPSCs model that may have potential application in human regenerative medicine.

scholarly journals Immunohistochemical localization of heat shock protein 25 (HSP 25) during root formation of the rat molar

2002 ◽  
Vol 267 (4) ◽  
pp. 321-329 ◽  
Author(s):  
Tomoyuki Onishi ◽  
Hanako Tsubone ◽  
Takashi Ooshima ◽  
Shizuo Sobue ◽  
Ashraf El-Sharaby ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Root Formation ◽  
Immunohistochemical Localization ◽  
Rat Molar
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