Anti-Inflammatory Effects of Besifloxacin, a Novel Fluoroquinolone, in Primary Human Corneal Epithelial Cells

2008 ◽  
Vol 33 (11-12) ◽  
pp. 923-932 ◽  
Author(s):  
Jin-Zhong Zhang ◽  
Megan E. Cavet ◽  
Keith W. Ward
Keyword(s):  
Epithelial Cells ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial ◽  
Human Corneal Epithelial Cells ◽  
Anti Inflammatory

scholarly journals Anandamide Concentration-Dependently Modulates Toll-Like Receptor 3 Agonism or UVB-Induced Inflammatory Response of Human Corneal Epithelial Cells

2021 ◽  
Vol 22 (15) ◽  
pp. 7776
Author(s):  
Ágnes Angyal ◽  
Zsófia Pénzes ◽  
Shahrzad Alimohammadi ◽  
Dorottya Horváth ◽  
Lili Takács ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Response ◽  
Toll Like Receptor ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial ◽  
Uvb Irradiation ◽  
Human Corneal Epithelial Cells ◽  
Anti Inflammatory

Photodamage-induced and viral keratitis could benefit from treatment with novel nonsteroid anti-inflammatory agents. Therefore, we determined whether human corneal epithelial cells (HCECs) express members of the endocannabinoid system (ECS), and examined how the endocannabinoid anandamide (AEA, N-arachidonoyl ethanolamine) influences the Toll-like receptor 3 (TLR3) agonism- or UVB irradiation-induced inflammatory response of these cells. Other than confirming the presence of cannabinoid receptors, we show that endocannabinoid synthesizing and catabolizing enzymes are also expressed in HCECs in vitro, as well as in the epithelial layer of the human cornea in situ, proving that they are one possible source of endocannabinoids. p(I:C) and UVB irradiation was effective in promoting the transcription and secretion of inflammatory cytokines. Surprisingly, when applied alone in 100 nM and 10 μM, AEA also resulted in increased pro-inflammatory cytokine production. Importantly, AEA further increased levels of these cytokines in the UVB model, whereas its lower concentration partially prevented the transcriptional effect of p(I:C), while not decreasing the p(I:C)-induced cytokine release. HCECs express the enzymatic machinery required to produce endocannabinoids both in vitro and in situ. Moreover, our data show that, despite earlier reports about the anti-inflammatory potential of AEA in murine cornea, its effects on the immune phenotype of human corneal epithelium may be more complex and context dependent.

scholarly journals Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study

Eye ◽  
2015 ◽  
Vol 29 (7) ◽  
pp. 964-971 ◽  
Author(s):  
J Ye ◽  
Y-F Xu ◽  
L-X Lou ◽  
K Jin ◽  
Q Miao ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
In Vitro Study ◽  
Vitro Study ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial ◽  
Human Corneal Epithelial Cells ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory effects of paeoniflorin from Paeonia lactiflora Pall. on human corneal epithelial cells and a mouse model of dry eye disease

RSC Advances ◽  
2019 ◽  
Vol 9 (23) ◽  
pp. 12998-13006 ◽  
Author(s):  
Mincong Zhao ◽  
Li Liu ◽  
Yating Zheng ◽  
Guangrong Liu ◽  
Biao Che ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mouse Model ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Paeonia Lactiflora ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial ◽  
Human Corneal Epithelial Cells ◽  
Anti Inflammatory

Dry eye disease (DED) is characterized by increased osmolality of tears due to a lack of production or increased evaporation of tears.

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