scholarly journals Development of antibiotic resistance and options to replace antimicrobials in animal diets

2001 ◽  
Vol 60 (3) ◽  
pp. 291-299 ◽  
Author(s):  
Knud Erik ◽  
Bach Knudsen
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Chemical Properties ◽  
Gut Health ◽  
Growth Promoters ◽  
Eu Member States ◽  
Physico Chemical ◽  
Antimicrobial Growth Promoters ◽  
Experimental Challenge ◽  
The Eu

As there is a risk of developing antibiotic resistance, a number of commonly-used antimicrobial growth promoters have been banned in the EU member states. This decision has put new emphasis on using the diet to control enteric bacterial infections of pigs. Dietary carbohydrates constitute a major proportion of diets for pigs, and the carbohydrate fraction has a diverse composition, with different properties in the gastrointestinal tract, some of which are of importance to gut health. Findings from different studies indicate that dietary carbohydrate composition influences the expression of swine dysentery and infection with nematode worms after experimental challenge withBrachyspira hyodesenteriaeandOesophagostumum dentatumrespectively. In both cases the type, amount and physico-chemical properties of the carbohydrates entering the large intestine played an important role in the infection, and emerging data suggest a synergism between different porcine pathogens. There is also increasing evidence that the feed structure, which relates to the type of plant material in the diet and the way it is processed, can be used to reduceSalmonellaprevalence at the herd level. However, it should be stressed that using the diet to manage gut health is not straightforward, since the expression of a pathogen in many cases requires the presence of other components of the commensal biota.

Probiotic Attributes of Lactobacillus fermentum NKN51 Isolated from Yak Cottage Cheese and the Impact of Its Feeding on Growth, Immunity, Caecal Microbiology and Jejunal Histology in the Starter Phase of Broiler Birds

2020 ◽  
Author(s):  
Ajit S. Yadav ◽  
Geeta . ◽  
Suchismita Pradhan ◽  
Ravi Rajoria ◽  
Asok Kumar M ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Production Performance ◽  
Lactobacillus Fermentum ◽  
Cottage Cheese ◽  
Great Success ◽  
Meat Industry ◽  
Poultry Production ◽  
Gut Health ◽  
Growth Promoters ◽  
The Impact

Background: The discovery of antibiotics was a great success in control of the pathogenic infections in living beings. In addition, it also played a significant role in upliftment of the meat industry with their use as the growth promoters in the food animals including poultry. However, massive and incorrect use of antibiotics has resulted in the adverse outcome of antibiotic resistance over the years. In order to limit the antibiotic resistance at industry level itself, exploration of the possible alternatives such as probiotics is the need of the hour to replace the antibiotics in poultry industry without compromising the productivity. Hence, the present study was conducted to explore the effects of a novel probiotic bacterium, Lactobacillus fermentum NKN51 on the production performance of the broilers with an aim to replace the antibiotics in poultry production. Methods: In the present study, a total of 128 broiler birds were grouped randomly into four treatment groups which were fed basal diet (BD) along with the different levels of L. fermentum NKN51,viz.,T1 (BD+107cfu/gm), T2(BD+106cfu/gm), T3 (BD+105cfu/gm) and T4 or control (BD only) for a period of 28 days so as to observe the effect of Lactobacillus fermentum NKN51 in the starter phase of the broiler birds in terms of growth, immunity, gut health and physiology. Result: The result revealed that the group of broiler birds supplemented with Lactobacillus fermentum NKN51 at the level of 107cfu/gm of basal feed had significantly better growth performance, cell mediated and humoral immunity, gut health and jejunal histology in terms of villus height, VH:CD ratio and intestinal absorption capacity. Thus, Lactobacillus fermentum NKN51 was found as an ideal probiotic supplement exhibiting better potential in enhancing the efficiency of broiler birds in terms of improved productivity.

scholarly journals Antimicrobial resistance in veterinary medicine ? issues and controversies from an Australian perspective

2007 ◽  
Vol 28 (4) ◽  
pp. 180 ◽  
Author(s):  
Mary D Barton
Keyword(s):  
Veterinary Medicine ◽  
Antimicrobial Resistance ◽  
Vancomycin Resistance ◽  
Growth Promoters ◽  
Treatment And Prevention ◽  
Livestock Feeds ◽  
Regulatory Changes ◽  
Antimicrobial Growth Promoters ◽  
The Eu

Antimicrobial resistance in veterinary isolates came to renewed prominence in the late 1990s in response to the recognition of an association between the use of avoparcin as a growth promotant in livestock feeds and vanA vancomycin resistance in enterococcal pathogens in humans 1. Since then there have been many regulatory changes in many countries that have resulted in a reduction in use of antimicrobial growth promoters (AGPs) in livestock feeds. The EU has banned the use of most growth promoters and in Australia post-JETACAR avoparcin (a glycopeptide) has been voluntarily withdrawn from the market by the manufacturer (in 2000), recommendations have been made to restrict the use of virginiamycin (a streptogrammin) to a prescription-only medicine for treatment and prevention of some specific conditions, and a review of macrolide AGPs is in the wings. In addition, many of the industries have voluntarily reduced or ceased their use of some of these products. For example, the pig industry stopped use of avoparcin in 1997 and the use of virginiamycin has been curtailed in the meat chicken industry.

scholarly journals Kontrola antibiotika u mesu i mesnim proizvodima u Europskoj Uniji

Meso ◽  
2019 ◽  
Vol 21 (3) ◽  
pp. 279-294
Author(s):  
Nina Bilandžić ◽  
Đurđica Božić Luburić ◽  
Božica Solomun Kolanović ◽  
Ines Varga ◽  
Ivana Varenina
Keyword(s):  
Intestinal Flora ◽  
Meat Products ◽  
Consumer Health ◽  
The European Union ◽  
Bacterial Strains ◽  
Growth Promoters ◽  
Negative Effects ◽  
Eu Member States ◽  
Council Directive ◽  
The Eu

Today, more than 400 drugs in veterinary medicine are used in three main purposes, in the treatment of microbial infections, infection prevention, and growth promoters in order to achieve a faster animal growth. Residues of medicines in meat and meat products can have a number of negative effects on consumer health, ranging from hypersensitivity to cancerous, mutagenic or teratogenic effects, normal intestinal flora disorders, and antibiotic-resistant bacterial strains. In the European Union (EU), the largest meat producers are Spain, Italy, Germany, Poland, France and the United Kingdom, which also have the largest drug sales. The largest quantities of drugs sold were found for tetracyclines, penicillins and sulphonamides whose combined sales at EU level in 2015 were 69.6 % and in Croatia 76.7 %. EU members under Council Directive 96/23/EC carry out control of residues of veterinary drugs according to national residue monitoring plans (NRMP) in animals used for food production. Screening and confirmatory methods are used to control of drug residues. Most commonly, liquid chromatography in combination with tandem mass spectrometry is used. Today, priority is the development of effective multimethods that allow simultaneous analysis of residues of different antibiotic families. Every year, the European Food Safety Authority (EFSA) summarizes the results of the NRMP of the EU Member States in a joint report. The total number of non-compliant antibiotic results in meat samples in 2015 and 2016 was 250 and 195, respectively. The highest number of non-compliant results was found for tetracyclines. A coordinated and comprehensive control of veterinary medicines is established in the EU necessary for a high level of consumer health protection. The system of regulations just as well as analytical methods are constantly being upgraded and developed.

scholarly journals Incidence of Tetracycline and Erythromycin Resistance in Meat-Associated Bacteria: Impact of Different Livestock Management Strategies

2021 ◽  
Vol 9 (10) ◽  
pp. 2111
Author(s):  
Cecilia Fontana ◽  
Vania Patrone ◽  
Constanza Maria Lopez ◽  
Lorenzo Morelli ◽  
Annalisa Rebecchi
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Bacterial Resistance ◽  
Management Strategies ◽  
Tetracycline Resistance ◽  
Animal Husbandry ◽  
Growth Promoters ◽  
Erythromycin Resistance ◽  
Coagulase Negative Staphylococci ◽  
Associated Bacteria

The extensive use of antibiotics as growth promoters, or their continued abusive misuse to cure or prevent the onset of bacterial infections as occurs in the intensive farming, may have played a pivotal role in the spread of reservoirs of antibiotic resistance (AR) among food-associated bacteria including pathogens representing risks to human health. The present study compares the incidence of tetracycline and erythromycin resistances in lactic acid bacteria (LAB) and coagulase negative staphylococci (CNS) from fermented products manufacturing using meat from intensive animal husbandry (industrialized manufacturing Italian salami) and from extensive farms (artisanal sausages facilities pork and llama Argentinean sausages). A higher incidence of tetracycline resistance (TET-R) compared to erythromycin resistance (ERY-R) was observed among the 205 isolates. Unlike CNS strains, the LAB showed a significant correlation between the TET-R and the ERY-R phenotypes. Genotypic assessment shows a high correlation with tetK and tetM for the TET-R strains and with ermB and ermC for the ERY-R strains. Multiple correspondence analyses have highlighted the association between AR phenotypes and CNS species isolated from Italian salami, while the susceptible phenotypes were associated with the LAB species from Argentinean sausages. Since antibiotic resistance in meat-associated bacteria is a very complex phenomenon, the assessment of bacterial resistance in different environmental contexts with diverse farming practices and food production technologies will help in monitoring the factors influencing AR emergence and spread in animal production.

Decoration of specific sites on freeze-fractured membranes

1978 ◽  
Vol 36 (2) ◽  
pp. 140-141
Author(s):  
H. Gross ◽  
H. Moor
Keyword(s):  
Pure Water ◽  
Freeze Fracture ◽  
Chemical Properties ◽  
Surface Forces ◽  
Sulfate Pentahydrate ◽  
Copper Sulfate Pentahydrate ◽  
Physico Chemical ◽  
Water Of Hydration ◽  
Small Container ◽  
Binding Forces

Fracturing under ultrahigh vacuum (UHV, p ≤ 10-9 Torr) produces membrane fracture faces devoid of contamination. Such clean surfaces are a prerequisite foe studies of interactions between condensing molecules is possible and surface forces are unequally distributed, the condensate will accumulate at places with high binding forces; crystallites will arise which may be useful a probes for surface sites with specific physico-chemical properties. Specific “decoration” with crystallites can be achieved nby exposing membrane fracture faces to water vopour. A device was developed which enables the production of pure water vapour and the controlled variation of its partial pressure in an UHV freeze-fracture apparatus (Fig.1a). Under vaccum (≤ 10-3 Torr), small container filled with copper-sulfate-pentahydrate is heated with a heating coil, with the temperature controlled by means of a thermocouple. The water of hydration thereby released enters a storage vessel.

Physico-Chemical Properties of Recombinant Desulphatohirudin

1990 ◽  
Vol 63 (03) ◽  
pp. 499-504 ◽  
Author(s):  
A Electricwala ◽  
L Irons ◽  
R Wait ◽  
R J G Carr ◽  
R J Ling ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gel Filtration ◽  
Chemical Properties ◽  
Alpha Helix ◽  
Apparent Molecular Weight ◽  
Correlation Spectroscopy ◽  
Nmr Studies ◽  
Recombinant Hirudin ◽  
Physico Chemical ◽  
Recombinant Molecule

SummaryPhysico-chemical properties of recombinant desulphatohirudin expressed in yeast (CIBA GEIGY code No. CGP 39393) were reinvestigated. As previously reported for natural hirudin, the recombinant molecule exhibited abnormal behaviour by gel filtration with an apparent molecular weight greater than that based on the primary structure. However, molecular weight estimation by SDS gel electrophoresis, FAB-mass spectrometry and Photon Correlation Spectroscopy were in agreement with the theoretical molecular weight, with little suggestion of dimer or aggregate formation. Circular dichroism studies of the recombinant molecule show similar spectra at different pH values but are markedly different from that reported by Konno et al. (13) for a natural hirudin-variant. Our CD studies indicate the presence of about 60% beta sheet and the absence of alpha helix in the secondary structure of recombinant hirudin, in agreement with the conformation determined by NMR studies (17)

Physico-chemical properties of the rare-earth metals, scandium, and yttrium

1963 ◽  
Vol 79 (2) ◽  
pp. 263-293 ◽  
Author(s):  
E.M. Savitskii ◽  
V.F. Terekhova ◽  
O.P. Naumkin
Keyword(s):  
Rare Earth ◽  
Rare Earth Metals ◽  
Chemical Properties ◽  
Physico Chemical ◽  
The Rare Earth

EUROPEAN UNION´S SUGAR MARKET CONCENTRATION UNDER THE SUGAR QUOTA PRODUCTION SYSTEM

2015 ◽  
Author(s):  
Ľuboš SMUTKA ◽  
Helena ŘEZBOVÁ ◽  
Patrik ROVNÝ
Keyword(s):  
United Kingdom ◽  
Quota System ◽  
Eu Member States ◽  
The United Kingdom ◽  
Sugar Market ◽  
Current Production ◽  
High Dynamic ◽  
Production Capacities ◽  
Very High ◽  
The Eu

The European sugar beet quota system is in very high dynamic process in recent years. The number of sugar companies involved in this system has been constantly decreasing. The aim of this paper is to define subjects (companies/alliances), which possess the current production capacities working under the production quotas system. The paper is determining especially the level of beet sugar production quota holder system concentration using the Herfindahl-Hirschman Index. The paper provides the following findings. The European quota holder system is extremely concentrated and it is becoming more and more dominated by fewer players. Sugar quota is distributed among 19 EU-Member States. In this regard, the quota is generous, especially in relation to France, Germany, Poland and United Kingdom. In Finland, Lithuania, Hungary, Sweden, Denmark, the Netherlands, Slovakia and the United Kingdom controlled by two or even one subject (companies, alliances). There is a large discrepancy between political efforts to distribute equitable R 1308/2013-sugar quotas among states and the actual reality of those distributions. While the EU-quota holder system does not indicate an extreme concentration, an analysis according to the headquarters´ location and allocated quotas to owners of production capacities provides the evidence of extreme concentration.

BIOECONOMY DEVELOPMENT POTENTIAL BASED ON MORE EFFICIENT LAND USE IN THE EU

2015 ◽  
Author(s):  
Irina PILVERE ◽  
Aleksejs NIPERS ◽  
Bartosz MICKIEWICZ
Keyword(s):  
Green Growth ◽  
Member States ◽  
Eu Member States ◽  
Growing Stock ◽  
Europe 2020 ◽  
Europe 2020 Strategy ◽  
Analysis And Synthesis ◽  
Key Industries ◽  
The Eu ◽  
Production Resource

Europe 2020 Strategy highlights bioeconomy as a key element for smart and green growth in Europe. Bioeconomy in this case includes agriculture, forestry, fisheries, food and pulp and paper production, parts of chemical, biotechnological and energy industries and plays an important role in the EU’s economy. The growth of key industries of bioeconomy – agriculture and forestry – highly depends on an efficient and productive use of land as a production resource. The overall aim of this paper is to evaluate opportunities for development of the main sectors of bioeconomy (agriculture and forestry) in the EU based on the available resources of land. To achieve this aim, several methods were used – monographic, analysis and synthesis, induction and deduction, statistical analysis methods. The findings show that it is possible to improve the use of land in the EU Member States. If all the Member States reached the average EU level, agricultural products worth EUR 77 bln would be annually additionally produced, which is 19 % more than in 2014, and an extra 5 billion m3 volume of forest growing stock would be gained, which is 20 % more than in 2010.

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