Macronutrient intake, glycaemic index and glycaemic load of older Australian subjects with and without diabetes: baseline data from the Blue Mountains Eye Study

2006 ◽  
Vol 96 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Alan W. Barclay ◽  
Jennie C. Brand-Miller ◽  
Paul Mitchell
Keyword(s):  
Glycaemic Index ◽  
Baseline Data ◽  
Macronutrient Intake ◽  
Blue Mountains ◽  
Glycaemic Load ◽  
Blue Mountains Eye Study

Evaluating the associations between obesity and age-related cataract: a Mendelian randomization study

2019 ◽  
Vol 110 (4) ◽  
pp. 969-976 ◽  
Author(s):  
Ava Grace Tan ◽  
Annette Kifley ◽  
Victoria M Flood ◽  
Elizabeth G Holliday ◽  
Rodney J Scott ◽  
...  
Keyword(s):  
Instrumental Variable ◽  
Protein Intake ◽  
Mendelian Randomization ◽  
Population Based ◽  
Macronutrient Intake ◽  
Logistic Regression Models ◽  
Blue Mountains ◽  
Age Related ◽  
Blue Mountains Eye Study ◽  
Adjusted Logistic Regression

ABSTRACT Background The obesity–cataract association has been inconsistently reported. The fat mass and obesity–related (FTO) single-nucleotide polymorphism (SNP) rs9939609 is a major SNP associated with obesity and has been used as an instrumental variable for obesity in a Mendelian randomization (MR) approach. An interaction between the FTO SNP and macronutrient intake for obesity was suggested previously. Objective The aim of this study was to assess the associations between obesity and cataract, using FTO SNP rs9939609 as an instrumental variable in an MR approach, and explore interactions of this SNP with macronutrient intake in relation to risk of cataract in a population-based cohort. Methods The Blue Mountains Eye Study (BMES) is a longitudinal population-based study of common eye disease. Of 3654 baseline participants of the BMES (1992–1994), 2334 (75.8% of survivors) and 1952 (76.7% of survivors) were followed 5 and 10 y later. During the 5-y follow-up, 1174 new participants were examined. Cumulative cataract was defined as the presence of cortical, nuclear, or posterior subcapsular (PSC) cataract at any visit, following the Wisconsin Cataract Grading System. Imputed dosage of the FTO SNP rs9939609 was used. Quintiles of macronutrient intake (carbohydrates, protein, fats) were derived from an FFQ. ORs and 95% CIs were estimated using multivariable-adjusted logistic regression models. Results After multivariable adjustment, there were no associations between BMI and any cataract types in MR models using rs9939609 as an instrumental variable. However, an interaction between rs9939609 and protein intake for PSC cataract risk was suggested (P = 0.03). In analyses stratified by quintiles of protein intake, each minor allele of rs9939609 was associated with increased odds of PSC (OR: 2.14; 95% CI: 1.27, 3.60) in the lowest quintile subgroup only. Conclusions Obesity was not causally associated with age-related cataract. However, among persons in the lowest quintile of protein intake, obesity may be associated with PSC cataract.

Dietary Macronutrient Intake and Five-Year Incident Cataract: The Blue Mountains Eye Study

2007 ◽  
Vol 143 (6) ◽  
pp. 932-939.e1 ◽  
Author(s):  
Bradley S. Townend ◽  
Marcia E. Townend ◽  
Victoria Flood ◽  
George Burlutsky ◽  
Elena Rochtchina ◽  
...  
Keyword(s):  
Macronutrient Intake ◽  
Blue Mountains ◽  
Blue Mountains Eye Study

scholarly journals Dietary Fibre Intake and the 10-Year Incidence of Tinnitus in Older Adults

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4126
Author(s):  
Diana Tang ◽  
Yvonne Tran ◽  
Giriraj S. Shekhawat ◽  
George Burlutsky ◽  
Paul Mitchell ◽  
...  
Keyword(s):  
Dietary Fibre ◽  
Glycaemic Index ◽  
Protective Effects ◽  
Total Carbohydrate ◽  
Blue Mountains ◽  
Glycaemic Load ◽  
Increased Risk ◽  
Insoluble Fibre ◽  
Dietary Fibre Intake ◽  
Incidence Analysis

Tinnitus is the phantom perception of sound in the ears or head that increases in prevalence as age increases. With strong evidence supporting the benefits of dietary fibre for vascular health and hearing loss, intake of dietary fibre may also have a role in the prevention of tinnitus symptoms. This longitudinal study aims to determine the association between the intake of dietary fibre and other carbohydrate nutrition variables including glycaemic index (GI), glycaemic load (GL) and total carbohydrate intakes, and incident tinnitus over 10 years. Of the 1730 participants (aged ≥50 years) from the Blue Mountains Hearing Study with complete baseline data on tinnitus symptoms and carbohydrate intakes, 536 (31%) cases of tinnitus were identified and excluded from further incidence analysis. Dietary data were collected using a validated semi-quantitative food frequency questionnaire to determine intakes of total dietary fibre and fibre contributions from cereals, vegetables, and fruit. A purpose-built database based on Australian GI values was used to calculate mean GI. Lower versus higher intakes of fruit fibre (≤3.6 g/day vs. >3.6 g/day) and cereal fibre (≤4.2 g/day vs. >4.2 g/day) were significantly associated with a 65% (HR = 1.65; 95% CI: 1.15–2.36) and 54% (HR = 1.54; 95% CI: 1.07–2.22) increased risk of developing tinnitus over 10 years, respectively. Associations between intake of other carbohydrate nutrients and incident tinnitus were mostly non-significant. In summary, our study showed modest associations between intake of dietary fibre and incident tinnitus. The protective effects of fibre, particularly insoluble fibre, could underlie observed associations by reducing the risk of tinnitus via vascular risk factors such as cardiovascular disease. Further longitudinal studies evaluating different types and sources of fibre and tinnitus risk are needed to confirm our study findings.

Intraocular Pressure Over the Clinical Range of Blood Pressure: Blue Mountains Eye Study Findings

2005 ◽  
Vol 140 (1) ◽  
pp. 131-132 ◽  
Author(s):  
Paul Mitchell ◽  
Anne J. Lee ◽  
Jie Jin Wang ◽  
Elena Rochtchina
Keyword(s):  
Blood Pressure ◽  
Intraocular Pressure ◽  
Blue Mountains ◽  
Blue Mountains Eye Study

scholarly journals Glycaemic index values for commercially available potatoes in Great Britain

2005 ◽  
Vol 94 (6) ◽  
pp. 917-921 ◽  
Author(s):  
C. Jeya K. Henry ◽  
Helen J. Lightowler ◽  
Caroline M. Strik ◽  
Michael Storey
Keyword(s):  
Blood Glucose ◽  
Great Britain ◽  
Glycaemic Index ◽  
Crossover Design ◽  
Repeated Measure ◽  
Glycaemic Response ◽  
Potato Varieties ◽  
Glycaemic Load ◽  
Wide Range ◽  
Finger Prick

The glycaemic response to eight potato varieties commercially available in Great Britain was compared against a glucose standard in a non-blind, randomised, repeated measure, crossover design trial. Seventeen healthy subjects (three males, fouteen females), mean age 32 (sd 13) years and mean BMI 22·3 (sd 3·6) kg/m2, were recruited to the study. Subjects were served portions of eight potato varieties and a standard food (glucose), on separate occasions, each containing 50 g carbohydrate. Capillary blood glucose was measured from finger-prick samples in fasted subjects (0 min) and at 15, 30, 45, 60, 90 and 120 min after the consumption of each test food. For each potato variety, the glycaemic index (GI) value was calculated geometrically by expressing the incremental area under the blood glucose curve (IAUC) as a percentage of each subject's average IAUC for the standard food. The eight potato varieties exhibited a wide range in GI values from 56 to 94. A trend was seen whereby potatoes with waxy textures produced medium GI values, whilst floury potatoes had high GI values. Considering the widespread consumption of potatoes in Great Britain (933–1086 g per person per week), this information could be used to help lower the overall GI and glycaemic load of the diets of the British population.

Long-term Topical Timolol and Blood Lipids: The Blue Mountains Eye Study

2000 ◽  
Vol 9 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Paul Mitchell ◽  
Jie Jin Wang ◽  
Robert G. Cumming ◽  
Philip House ◽  
John D. F. England
Keyword(s):  
Blood Lipids ◽  
Blue Mountains ◽  
Blue Mountains Eye Study

Association of glycaemic index and glycaemic load with metabolic syndrome in an Iranian adult population: Isfahan Healthy Heart Program

2016 ◽  
Vol 74 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Noushin Mohammadifard ◽  
Marjan Mansourian ◽  
Firouzeh Sajjadi ◽  
Maryam Maghroun ◽  
Ali Pourmoghaddas ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Glycaemic Index ◽  
Glycaemic Load

Retinal Vessel Caliber and Myopic Retinopathy: The Blue Mountains Eye Study

2011 ◽  
Vol 18 (6) ◽  
pp. 275-280 ◽  
Author(s):  
Haitao Li ◽  
Paul Mitchell ◽  
Elena Rochtchina ◽  
George Burlutsky ◽  
Tien Y. Wong ◽  
...  
Keyword(s):  
Retinal Vessel ◽  
Blue Mountains ◽  
Retinal Vessel Caliber ◽  
Blue Mountains Eye Study
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