scholarly journals The rat as a model for pigs: comparative values for the digestibility of NSP and other macronutrients

2003 ◽  
Vol 90 (2) ◽  
pp. 373-383 ◽  
Author(s):  
Elisabeth Wisker ◽  
Knud Erik Bach Knudsen
Keyword(s):  
Organic Matter ◽  
Wistar Rats ◽  
Protein Digestibility ◽  
Dietary Level ◽  
Cell Structures ◽  
Close Relationship ◽  
Male Wistar Rats ◽  
Small Intestinal ◽  
Intestinal Digestibility

The present investigation was undertaken to study whether conventional male Wistar rats could be used as a model for pigs with regard to total tract digestibilities of NSP and macronutrients and whether nebacitin-treated rats could be used as a model for small intestinal digestibility in pigs. Nineteen experimental diets prepared from different fractions of wheat and oats, and which all had been evaluated in experiments with ileal cannulated pigs, were used for the present study. There was a close relationship between the total tract digestibilities of organic matter in the two species. The same was the case with regard to the digestibility of total NSP and arabinoxylans, but the values were on average 6 % lower in rats than in pigs. On average, there were no significant differences between rats and pigs with regard to faecal protein digestibility. However, protein in oat-based diets was significantly better digested in the rat than the pig. The digestibility of fat was consistently higher in rats than in pigs, with the biggest difference being found in oat-based diets, in which most of the fat was locked in cell structures. For the wheat-based diets, in which a large proportion of the fat was present as added fat, there was a greater similarity between the two species. In nebacitin-treated rats the digestibility of organic matter, starch, protein and fat was negatively related to the dietary level of NSP, but this model could not be used to predict the small intestinal digestibility of NSP and macronutrients in ileal-cannulated pigs.

scholarly journals The effect of dietary protein source and guar gum on gastrointestinal growth and enteroglucagon secretion in the rat

1987 ◽  
Vol 58 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Susan Southon ◽  
Jennifer M. Gee ◽  
I. T. Johnson
Keyword(s):  
Dietary Protein ◽  
Wistar Rats ◽  
Guar Gum ◽  
Protein Source ◽  
Endocrine Activity ◽  
Intestinal Length ◽  
Daily Food ◽  
Male Wistar Rats ◽  
Small Intestinal ◽  
Dietary Protein Source

1. Male Wistar rats (approximately 100 g) were given fibre-free semi-synthetic diets containing either casein or albumin (168 g/kg diet) as the protein source with or without guar gum (75 g/kg diet) (casein, albumin, casein- guar gum and albumin-guar gum groups).2. Small intestinal length, weights of caecal tissue and contents and plasma enteroglucagon concentration were significantly increased in guar-gum-fed animals compared with the fibre-free groups.3. Total caecal weight and plasma enteroglucagon concentration were higher in the albumin-guar gum group compared with the casein-guar gum group. The weights of caecal tissue and contents were significantly increased in rats given the fibre-free albumin diet compared with those consuming a similar diet with casein as the protein source, although daily food intake tended to be lower.4. It is concluded that the effect of materials classed as dietary fibre may be significantly influenced by the non- polysaccharide component of the diet, and that such interactions may influence both the growth and endocrine activity of the gastrointestinal tract.

scholarly journals Effect of sweet chestnut extract (Farmatan®) on the digestibility and bioavailability of nitrogen and some minerals in the laboratory rats

2016 ◽  
Vol 108 (1) ◽  
pp. 9
Author(s):  
Tatjana PIRMAN ◽  
Andrej OREŠNIK
Keyword(s):  
Organic Matter ◽  
Dry Matter ◽  
Protein Quality ◽  
Protein Digestibility ◽  
Mineral Elements ◽  
Control Group ◽  
Apparent Digestibility ◽  
Sweet Chestnut ◽  
Male Wistar Rats ◽  
Apparent Bioavailability

Study was conducted to investigate the dietary effect of hydrolysable tannin from sweet chestnut on the protein digestibility and bioavailability, dry matter and organic matter apparent digestibility and apparent digestibility and apparent bioavailability of some mineral elements. Ten male Wistar rats (98.9 g ± 25.6 g of body mass) were fed ad libitum with balanced diets. In the experimental diet 0.1 % of sweet chestnut extract (SCE) was added to the diet. Five days balance experiment takes place after fifteen days of adaptive period. SCE did not have any influence on the protein quality measurements or dry matter and organic matter apparent digestibility. Tannin significantly (<em>p</em> &lt; 0.05) decreased the digestibility and bioavailability of Ca and Fe. The digestibility of Na was unchanged (97.76 % and 97.31 % in control and SCE group, respectively), but bioavailability significantly decreased in SCE group (53.16 %) as compared to the control group (74.17 %). On the contrary, the apparent digestibility of Se significantly increased, (64.25 %) in SCE group compared to the control group (52.31 %).

Comparative study of alanine-ammo-peptidase and gamma-glutamyl-transferase activity in normal Wistar rat urine

1983 ◽  
Vol 17 (3) ◽  
pp. 246-251 ◽  
Author(s):  
S. Stoykova ◽  
C. Philippon ◽  
F. Labaille ◽  
D. Prevot ◽  
Y. Manuel
Keyword(s):  
Wistar Rats ◽  
Urine Volume ◽  
Wistar Rat ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Rat Urine ◽  
Gamma Glutamyl ◽  
Close Relationship ◽  
Male Wistar Rats ◽  
Glutamyl Transferase

24 h urinary alanine-amino-peptidase (AAP) and gamma-glutamyl transferase (GGT) activities were studied from the 3rd-7th month of life in male Wistar rats. A close relationship was found between AAP and GGT activity, except at the beginning and at the end of this period. At the end there appear 2 subgroups, the larger (70%) showing a strong correlation between AAP and GGT activity and the other (30%), demonstrating no correlation at all. A good correlation between AAP and GGT activities, creatinine, 24 h urine volume and 24 h creatinine output was found.

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats

2020 ◽  
pp. 1-6 ◽  
Author(s):  
Masoud Nasiri ◽  
Saja Ahmadizad ◽  
Mehdi Hedayati ◽  
Tayebe Zarekar ◽  
Mehdi Seydyousefi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Wistar Rats ◽  
Enzymatic Antioxidants ◽  
Acute Response ◽  
Total Antioxidant ◽  
Male Wistar Rats ◽  
Exercise Induced ◽  
And Control

Abstract. Physical exercise increases free radicals production; antioxidant supplementation may improve the muscle fiber’s ability to scavenge ROS and protect muscles against exercise-induced oxidative damage. This study was designed to examine the effects of all-trans resveratrol supplementation as an antioxidant to mediate anti-oxidation and lipid per-oxidation responses to exercise in male Wistar rats. Sixty-four male Wistar rats were randomly divided into four equal number (n = 16) including training + supplement (TS), training (T), supplement (S) and control (C) group. The rats in TS and S groups received a dose of 10 mg/kg resveratrol per day via gavage. The training groups ran on a rodent treadmill 5 times per week at the speed of 10 m/min for 10 min; the speed gradually increased to 30 m/min for 60 minutes at the end of 12th week. The acute phase of exercise protocol included a speed of 25 m/min set to an inclination of 10° to the exhaustion point. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activity, non-enzymatic antioxidants bilirubin, uric acid, lipid peroxidation levels (MDA) and the total antioxidant capacity (TAC) were measured after the exercise termination. The data were analyzed by using one-way ANOVA. The result showed that endurance training caused a significant increase in MDA level [4.5 ± 0.75 (C group) vs. 5.9 ± 0.41 nmol/l (T group)] whereas it decreased the total antioxidant capacity [8.5 ± 1.35 (C group) vs. 7.1 ± 0.55 mmol/l (T group)] (p = 0.001). In addition, GPx and CAT decreased but not significantly (p > 0.05). The training and t-resveratrol supplementation had no significant effect on the acute response of all variables except MDA [4.3 ± 1.4 (C group) vs. 4.0 ± 0.90 nmol/l (TS group)] (p = 0.001) and TAC [8.5 ± 0.90 (C group) vs. 6.6 ± 0.80 mmol/l (TS group)] (p = 0.004). It was concluded that resveratrol supplementation may prevent exercise-induced oxidative stress by preventing lipid peroxidation.

Augurin stimulates food intake in male Wistar rats

2013 ◽  
pp. 1-1
Author(s):  
Michael Patterson ◽  
John Tadross ◽  
Keisuke Suzuki ◽  
Kylie Beale ◽  
Charoltte Boughton ◽  
...  
Keyword(s):  
Food Intake ◽  
Wistar Rats ◽  
Male Wistar Rats

Pengaruh Profilaksis Ekstrak Ubi Jalar Ungu (Ipomoea batatas L.) terhadap Kadar Malondialdehida Hepar Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diinduksi Karagenan

2018 ◽  
Vol 15 (2) ◽  
pp. 146
Author(s):  
BRILIAN DINANTI ◽  
FITRI HANDAJANI
Keyword(s):  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Wistar Rats ◽  
Group Method ◽  
Control Group ◽  
Intraplantar Injection ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Potato Extract ◽  
Purple Sweet Potato

<p>Liver is an organ with complex metabolism. When the liver is inflamed, cellular immunity will defend against inflammatory agents by stimulating immune cells to produce reactive oxygen species (ROS). Excessive ROS accumulation cause oxydative stress with increased  liver malondialdehyde (MDA) level. Some researches showed that purple sweet potato contain flavonoids (anthocyanins) that functioned as antioxydants. This study aimed to show the prophylactic effect of purple sweet potato extract to the liver MDA level of male Wistar rats induced by carrageenan.</p><p>This study used post-only control group method using 18 male Wistar rats divided into 3 groups: group of rats without treatment, group of rats induced by 0,1 ml of 1% carrageenan by intraplantar injection on day-8, and group of rats given with 872 mg/kgBW of purple sweet potato extract for 7 days and induced by 0,1 ml of 1% carrageenan. In the end of the study, the liver MDA levels were measured by Thio-Barbituric Acid method on each groups.</p><p>The results of One-Way ANOVA test showed there was no significant difference (p = 0,290) between group of rats without treatment (<em>x̅</em>= 207,50) and group of rats induced by carrageenan (<em>x̅</em>=233,17). Then, there is no significant difference (p = 0.978) between group of rats induced by carrageenan and group of rats given with prophylactic purple sweet potato extract and induced by carrageenan (<em>x̅</em>= 232,50).</p><p>The conclusion of this study is giving intraplantar injection of carrageenan can increase liver MDA level insignificantly and giving prophylactic purple sweet potato extract has an effect to decrease the liver MDA level of rats induced by carragenan insignificantly because it contains anthocyanins as antioxidants.</p><p> </p><strong>Keywords: </strong>Liver, <em>Ipomoea batatas</em> L., Malondialdehyde, Anthocyanins

Sign in / Sign up

Export Citation Format

Share Document