scholarly journals Whole-body metabolism of glucose and lactate in productive sheep and cows

1983 ◽  
Vol 50 (2) ◽  
pp. 249-265 ◽  
Author(s):  
G. D. Baird ◽  
J. G. Van Der Walt ◽  
E. N. Bergman
Keyword(s):  
Body Weight ◽  
Dairy Cows ◽  
De Novo ◽  
Late Pregnancy ◽  
Whole Body ◽  
Early Lactation ◽  
Metabolic Pattern ◽  
Lactating Cows ◽  
Lactate Turnover ◽  
Whole Body Metabolism

1. Constant infusions of D-[U-14C]glucose, D-[6−3H]glucose and L-[U-14C]lactate were used to determine rates of apparent turnover, de novo production, disposal and interconversions of glucose and lactate, together with total recycling of glucose-C, in ewes and dairy cows during late pregnancy and early lactation. The cows were also examined while being fasted. In the fed animals, infusions were made within 5 h after the morning meal when steady-state conditions appeared to exist.2. In the ewes, circulating concentrations of glucose and lactate, and magnitudes of apparent turnovers of glucose and lactate, tended to be higher during lactation than during pregnancy, while the extent of interconversions of glucose and lactate tended to be lower.3. Although the metabolic pattern seen in the cows appeared to be similar to that of the ewes during pregnancy, there were clear differences during lactation. Thus, in the lactating cows, as compared with the lactating ewes, circulating concentrations of glucose and lactate were lower, as was apparent lactate turnover related to metabolic body-weight. Furthermore, the percentage of lactate turnover converted to glucose was higher.4. In the cows, fasting was characterized by low rates of apparent turnover of glucose and lactate and relatively high rates of interconversion of the two compounds.5. The results indicated that, under the conditions used in this study and when feeding is to recommended levels, carbohydrate metabolism in ewes is more precarious during late pregnancy than during early lactation, while in dairy cows it is more or less equally precarious in both physiological states.6. A further conclusion is that the extent of glucose–lactate interconversions, and thus Cori cycle activity, seems to be lower in ruminants than in other species.

Involvement of Plasma Endocannabinoids and the Hypothalamic Endocannabinoid System in Increasing Feed Intake after Parturition of Dairy Cows

2019 ◽  
Vol 110 (3-4) ◽  
pp. 246-257 ◽  
Author(s):  
Björn Kuhla ◽  
Volkhard Kaever ◽  
Armin Tuchscherer ◽  
Angela Kuhla
Keyword(s):  
Fatty Acid ◽  
Energy Metabolism ◽  
Dairy Cows ◽  
Feed Intake ◽  
Fatty Acid Amide Hydrolase ◽  
Peak Plasma ◽  
Acid Amide ◽  
Late Pregnancy ◽  
Early Lactation ◽  
Lactating Cows

The endocannabinoids (ECs) N-arachidonylethanolamide (anandamide; AEA) and 2-arachidonoylglycerol (2-AG) participate in the control of feed intake and energy metabolism. Most mammals increase their feed intake after parturition to cope with the increased energy and nutrient requirements for milk synthesis, thereby increasing their metabolic rate. Here we investigated in experiment 1 the regulation of plasma AEA and 2-AG concentrations during the transition from late pregnancy to early lactation in dairy cows, and analyzed in experiment 2 the expression of the EC system in the paraventricular nucleus (PVN) and the arcuate nucleus (ARC) of the hypothalamus of late and early lactating cows using immunohistochemistry. Cows in experiment 1 were retrospectively grouped based on peak plasma fatty acid concentrations to a high (H) or low (L) group. Feed intake was not different between groups before parturition, but was lower in H than L cows during early lactation. Plasma AEA and 2-AG concentrations increased 2.2- to 2.4-fold during early lactation, in which time plasma AEA concentrations rose faster in H cows than in L cows postpartum. Upregulation of N-acyl phosphatidylethanolamine-specific phospholipase D together with tending increased cannabinoid receptor 1 (CB1) expression, and downregulation of fatty acid amide hydrolase in early lactating cows suggested an increased PVN AEA tone. The abundance of CB1 in the ARC and diacylglycerol lipase-alpha was not different between late and early lactating cows, but PVN monoacylglycerol lipase expression was 30% higher in early lactating cows, indicating diminished PVN 2-AG concentrations. The results show a potential involvement of AEA in stimulating feed intake and of 2-AG in regulating energy metabolism of early lactating cows.

scholarly journals Determination metabolic and nutritional status in dairy cows during early and mid lactation

2016 ◽  
Vol 32 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Radojica Djokovic ◽  
Zoran Ilic ◽  
Vladimir Kurcubic ◽  
Milan Petrovic ◽  
Violeta Caro-Petrovic ◽  
...  
Keyword(s):  
Blood Serum ◽  
Dairy Cows ◽  
Metabolic Status ◽  
Early Lactation ◽  
Serum Concentrations ◽  
Nonesterified Fatty Acids ◽  
Lactating Cows ◽  
Lower Blood ◽  
Positive Correlations ◽  
Beta Hydroxybutyrate

The objective of the present study was to investigate nutritional and metabolic status in Simmental cows during early and mid-lactation. Fifteen early lactating cows and 15 mid lactating cows were chosen for the investigation. Blood samples were collected to measure beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), triglycerides (TG), glucose and the activity of aspartate transaminase (AST). Early lactation as compared to mid lactating cows were found to have significantly higher (P<0.05) blood serum concentrations of NEFA, BHB and AST and lower blood serum concentrations of glucose (P<0.05) and TG (P>0.05). Significantly negative correlations were observed between BHB and glucose (P<0.01), BHB and TG (P<0.05), NEFA and glucose (P<0.05). Significantly positive correlations were observed between NEFA and BHB (P<0.05), NEFA and AST (P<0.05), glucose and TG (P<0.01). The results suggest that these parameters can serve as useful indicators of the nutritional and metabolic status of dairy cows during lactation.

Adipose tissue progesterone concentrations in dairy cows during late pregnancy and early lactation

1996 ◽  
Vol 43 (1) ◽  
pp. 15-23 ◽  
Author(s):  
H. Hamudikuwanda ◽  
G. Gallo ◽  
E. Block ◽  
B.R. Downey
Keyword(s):  
Adipose Tissue ◽  
Dairy Cows ◽  
Late Pregnancy ◽  
Early Lactation

scholarly journals Comparison of performance and metabolism from late pregnancy to early lactation in dairy cows with elevated v. normal body condition at dry-off

animal ◽  
2019 ◽  
Vol 13 (7) ◽  
pp. 1478-1488 ◽  
Author(s):  
K. Schuh ◽  
H. Sadri ◽  
S. Häussler ◽  
L.A. Webb ◽  
C. Urh ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Body Condition ◽  
Late Pregnancy ◽  
Early Lactation ◽  
Normal Body

scholarly journals PSI-18 Adiponectin serum concentrations in late pregnancy and early lactation in primiparous and multiparous Holstein dairy cows.

2018 ◽  
Vol 96 (suppl_3) ◽  
pp. 65-65
Author(s):  
C Urh ◽  
J Denißen ◽  
I Harder ◽  
C Koch ◽  
E Stamer ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Late Pregnancy ◽  
Early Lactation ◽  
Serum Concentrations ◽  
Holstein Dairy Cows

scholarly journals Effects of supplements of folic acid, vitamin B12, and rumen-protected methionine on whole body metabolism of methionine and glucose in lactating dairy cows

2009 ◽  
Vol 92 (2) ◽  
pp. 677-689 ◽  
Author(s):  
A. Preynat ◽  
H. Lapierre ◽  
M.C. Thivierge ◽  
M.F. Palin ◽  
J.J. Matte ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Dairy Cows ◽  
Whole Body ◽  
Lactating Dairy Cows ◽  
Whole Body Metabolism

Prediction of body weight and composition in lactating dairy cows: Relationship between body condition score and body composition

2005 ◽  
Vol 2005 ◽  
pp. 19-19
Author(s):  
T. Yan ◽  
R. E. Agnew ◽  
C. S. Mayne
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Dairy Cows ◽  
Milk Production ◽  
Body Condition ◽  
Body Condition Score ◽  
Early Lactation ◽  
Lactating Dairy Cows ◽  
Condition Score ◽  
Body Concentration

Body condition of lactating dairy cows varies at different stages of lactation. Cows usually mobilise their body reserves to provide energy and protein for milk production in early lactation, and gain weight to deposit energy and protein for pregnancy at a later stage. The objective of the present study was to examine relationships between body condition score (CS) and body concentration of lipid, CP and energy.

Leptin interrelationships to energy-related metabolites and hormones in fed and fasted sheep

2002 ◽  
Vol 2002 ◽  
pp. 87-87 ◽  
Author(s):  
A.R.G. Wylie ◽  
D.J. Devlin ◽  
A.J. Bjourson
Keyword(s):  
Body Weight ◽  
Dairy Cows ◽  
Body Fat ◽  
Body Condition ◽  
Previous Investigation ◽  
Body Condition Score ◽  
Backfat Thickness ◽  
Early Lactation ◽  
Weak Correlation ◽  
Condition Score

A review of published leptin data for growing lambs, older ewes and mature dairy cows in late lactation showed that only 0.30-0.37 of the variation in blood leptin concentration was explained by differences in body fat variably expressed as % of liveweight (LW), backfat thickness and body condition score (BCS) respectively (Wylieet al., 2002). In dairy cows between 15d and 226d postpartum, Wylieet al(2002) observed no overall correlation between leptin at slaughter and lipid expressed as % of LW, empty body weight or carcase weight and only a weak correlation in cows in mid-lactation. Losses of fat during early lactation may ‘uncouple’ the link between leptin and fat and produce a bias across all of lactation. Another explanation is that leptin may be more closely linked with lipogenesis than with the amount of stored fat. This study revisits some metabolite and hormone data from a previous investigation of IGF-1 changes in fed, fasted and re-fed sheep in the light of more recently obtained leptin concentrations in the same animals.

Zinc deficiency impairs whole body accumulation of polyunsaturates and increases the utilization of [1-14C]linoleate for de novo lipid synthesis in pregnant rats

1995 ◽  
Vol 73 (9) ◽  
pp. 1246-1252 ◽  
Author(s):  
S. C. Cunnane ◽  
J. Yang
Keyword(s):  
Food Intake ◽  
Zinc Deficiency ◽  
De Novo ◽  
Control Diet ◽  
Lipid Synthesis ◽  
Whole Body ◽  
Deficient Diet ◽  
Pregnant Rats ◽  
Whole Body Metabolism ◽  
Zinc Deficient Diet

Zinc deficiency impairs the metabolism of polyunsaturates, but the degree to which its effects are independent of food intake are still in question. Identical amounts of a semiliquid control diet (26.4 mg zinc/kg) or moderately zinc deficient diet (3.2 mg zinc/kg) were tube fed to rats for 11 days during the second half of pregnancy to evaluate the specific effects of zinc deficiency on maternal utilization and fetal accumulation of polyunsaturates. The whole body fatty acid balance method was used to determine net accumulation of polyunsaturates and their whole-body disappearance. Incorporation of 14C from [1-14C]linoleate into maternal and fetal lipid classes was also studied on days 20–21. At term, zinc-deficient rats had significantly higher whole-body disappearance of linoleate and α-linolenate and lower accumulation of n−6 and n−3 long-chain polyunsaturates. Zinc-deficient rats had higher 14C activity in free cholesterol, saturates, and monounsaturates in several maternal organs but not in the fetuses. We conclude that during pregnancy, moderate zinc deficiency not affecting food intake or weight gain still alters whole-body metabolism of linoleate and α-linolenate towards increased β-oxidation and also increases the utilization of carbon from linoleate for de novo lipid synthesis.Key words: cholesterol, linoleate, α-linolenate, oxidation, polyunsaturates, pregnancy, zinc.

Addition of protected and unprotected fish oil to diets for dairy cows. I. Effects on the yield, composition and taste of milk

2002 ◽  
Vol 69 (4) ◽  
pp. 511-520 ◽  
Author(s):  
PIERRE LACASSE ◽  
JOHN J. KENNELLY ◽  
LOUIS DELBECCHI ◽  
CHARAF E. AHNADI
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Fish Oil ◽  
Milk Yield ◽  
Milk Fat ◽  
De Novo ◽  
Short Chain Fatty Acids ◽  
Lactating Cows ◽  
Silage Maize ◽  
Long Chain

Thirty Holstein cows in mid-lactation (158±20 DIM) were given a total mixed ration based on grass silage, maize silage and rolled barley. After a preliminary period of 1 week, this diet was supplemented with nothing (control), unprotected fish oil (3.7% of dry matter, DM), or two levels of glutaraldehyde-protected microcapsules of fish oil (1.5% and 3.0% of DM, respectively). Unprotected and protected supplements contained, respectively, 74% and 58% of DM as lipids. Cows given the unprotected supplement reduced their feed intake by >25%. Consequently, these cows lost body weight and produced less milk. DM intake, body weight, and milk yield were unaffected by protected fish oil. Fish oil reduced both milk fat and protein percentages, and decreased the proportion of short-chain fatty acids, stearic, and oleic acids in milk fat. Milk trans C18[ratio ]1 fatty acids increased in cows given both unprotected and protected fish oil. Milk fat content of very-long-chain n3 polyunsaturated fatty acids, including C20[ratio ]5 and C22[ratio ]6, increased with fish oil in the diet. Accordingly, the peroxide index increased and a taste panel was able to detect unusual taste in milk from cows consuming the higher level of protected fish oil and disliked the milk from cows given unprotected fish oil. In conclusion, when lactating cows consumed fish oil, milk concentration of long-chain n3 fatty acids increased and mammary de novo synthesis of fatty acids decreased, but milk yield and milk protein content were reduced, and the milk was more susceptible to oxidation and its taste was adversely affected.

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