scholarly journals Rate of endogenous methionine oxidation in rats at different levels of methionine intake

1983 ◽  
Vol 50 (1) ◽  
pp. 157-162 ◽  
Author(s):  
R. J. Neale ◽  
J. C. Waterlow
Keyword(s):  
Body Weight ◽  
Single Dose ◽  
Total Radioactivity ◽  
The Body ◽  
Female Rats ◽  
Methionine Oxidation ◽  
A Value ◽  
Intake Level ◽  
Different Levels ◽  
Fractional Loss

1. The fractional rates of loss of 14C and body-weight were measured in growing female rats after a single dose of [1-14C]methionine. After the dose, the rats were maintained for 30 d on diets containing graded amounts of methionine and killed at 30 d.2. By 20 d after the dose the level of labelling of body proteins was fairly uniform. From 20 to 30 d, 14CO2 was collected at intervals. The rats were killed at 30 d and the total radioactivity remaining in the body was measured.3. The fractional loss of 14CO2 between days 20 and 30 was constant regardless of methionine intake except at the highest intake level.4. After correcting the fractional loss of 14CO2 for urinary 14C loss, a value of 35 mg/kg body-weight (20 mg/kg body-weight0·75) was obtained for the rate of endogenous methionine oxidation.

Acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii (Miq.) Miq. stem bark in rats

2021 ◽  
Vol 10 (2) ◽  
pp. 89-97
Author(s):  
EL Lappa ◽  
◽  
C Bogning Zangueu ◽  
EL Nguemfo ◽  
JJ Kojom Wanche ◽  
...  
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Chronic Toxicity ◽  
Hematological Parameters ◽  
Lethal Dose ◽  
Relative Weight ◽  
Stem Bark ◽  
The Body ◽  
Female Rats ◽  
Male Rats

Ficus vogelii is a medicinal plant mainly found in tropical Africa and reported to treat inflammatory complaints. This study aims to evaluate the acute and sub-chronic toxicity of the aqueous extract of Ficus vogelii stem bark in wistar rats. For acute study, aqueous extract at a single dose of 5000 mg/kg body weight was administered to female rats and observed for 14 days. In the sub-chronic study, the extract was administered daily to both sex rats at the doses of 100, 200, 400, and 600 mg/kg body weight for 28 consecutive days. Body weight was measured weekly, while hematological, biochemical, and histopathological parameters were analyzed after euthanize. Aqueous extract of Ficus vogelii at all tested doses didn’t produced any mortality or significant change on the body weight and relative weight of rats on acute and sub-chronic studies. The lethal dose 50 was estimated greater than 5000 mg/kg (DL50˃5000 mg/kg). Hematological parameters were recorded non-significant in all treated rats. Aqueous extract at 600 mg/kg significantly changed transaminases and alkaline phosphatase activities, these changes were reversible in satellites. The concentrations of bilirubin was increased at 200 and 600 mg/kg in male rats, at 100, 400 mg/kg in female rats. The levels of lipids markers didn’t changed, except the significant decrease of LDL-cholesterol. Histological examination didn’t showed any change in the architecture of the liver and kidney of rats treated compared to control. Thus aqueous extract of Ficus vogelii stem bark didn’t produced adverse effects in rats after oral acute and sub-chronic treatment.

scholarly journals Effect of supplemented dietary protein on certain haematological values and meat yield characteristics of broiler birds

1970 ◽  
Vol 2 (2) ◽  
pp. 121-123 ◽  
Author(s):  
MS Alam ◽  
N Ahmad ◽  
MA Miah ◽  
R Islam
Keyword(s):  
Body Weight ◽  
Dietary Protein ◽  
Body Weight Gain ◽  
The Body ◽  
Meat Yield ◽  
Haematological Values ◽  
Significant Difference ◽  
The Mean ◽  
Group B ◽  
Different Levels

The effect of different levels of supplemented dietary protein on body weight, certain haematological values and meat yield characteristics in 20 "Shaver Star Bro" broilers was studied during the period from 02 March to 12 April 2002. The broilers were randomly assigned to four equal groups (A to D) each consisting of 5 birds. Group A was considered as control, fed only with commercial ration and other three groups were treated with extra dietary protein supplement @ 5%, 10% and 15% as group B, C and D respectively. Increased body weight was recorded in group B and the body weight decreases as the level of protein increased from 5% to 10% and 15% and the decrease was linear. No differences in haematological values were observed among the groups but the TEC varied significantly (p < 0.05). The mean weight of breast meat, drum stick meat varied significantly (p < 0.01). The shank weight varied significantly (p < 0.05) but there was no significant difference among the mean weight of thigh meat and wing meat corresponding to the different levels of supplemented dietary protein. It can be concluded that 5% supplemented dietary protein with commercial ration gives better result in respect to body weight gain, haematological values and meat yield characteristics.Key words: dietary protein; haematological values; meat yield; broiler birdsdoi: 10.3329/bjvm.v2i2.2543Bangl. J. Vet. Med. (2004). 2 (2): 121-123

scholarly journals Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring

2007 ◽  
Vol 293 (3) ◽  
pp. R1056-R1062 ◽  
Author(s):  
Jacqueline Férézou-Viala ◽  
Anne-France Roy ◽  
Colette Sérougne ◽  
Daniel Gripois ◽  
Michel Parquet ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Maternal Diet ◽  
The Body ◽  
Female Rats ◽  
Leptin Resistance ◽  
High Fat ◽  
Leptin Sensitivity ◽  
The Impact

Epidemiological and animal studies suggest that the alteration of hormonal and metabolic environment during fetal and neonatal development can contribute to development of metabolic syndrome in adulthood. In this paper, we investigated the impact of maternal high-fat (HF) diet on hypothalamic leptin sensitivity and body weight gain of offspring. Adult Wistar female rats received a HF or a control normal-fat (C) diet for 6 wk before gestation until the end of the suckling period. After weaning, pups received either C or HF diet during 6 wk. Body weight gain and metabolic and endocrine parameters were measured in the eight groups of rats formed according to a postweaning diet, maternal diet, and gender. To evaluate hypothalamic leptin sensitivity in each group, STAT-3 phosphorylation was measured in response to leptin or saline intraperitoneal bolus. Pups exhibited similar body weights at birth, but at weaning, those born to HF dams weighed significantly less (−12%) than those born to C dams. When given the HF diet, males and females born to HF dams exhibited smaller body weight and feed efficiency than those born to C dams, suggesting increased energy expenditure programmed by the maternal HF diet. Thus, maternal HF feeding could be protective against adverse effects of the HF diet as observed in male offspring of control dams: overweight (+17%) with hyperleptinemia and hyperinsulinemia. Furthermore, offspring of HF dams fed either C or HF diet exhibited an alteration in hypothalamic leptin-dependent STAT-3 phosphorylation. We conclude that maternal high-fat diet programs a hypothalamic leptin resistance in offspring, which, however, fails to increase the body weight gain until adulthood.

EFFECTS OF ADRENALECTOMY ON THE RELEASE OF FOLLICLE-STIMULATING HORMONE AND THE ONSET OF PUBERTY IN FEMALE RATS

1977 ◽  
Vol 75 (3) ◽  
pp. 419-426 ◽  
Author(s):  
H. M. A. MEIJS-ROELOFS ◽  
P. KRAMER
Keyword(s):  
Body Weight ◽  
Adrenal Gland ◽  
Follicle Stimulating Hormone ◽  
The Body ◽  
Biologically Active ◽  
Female Rats ◽  
Vaginal Opening ◽  
Uterine Weight ◽  
Body Weights ◽  
Adrenalectomized Rats

The involvement of the adrenal gland in the release of gonadotrophins and the onset of puberty in female rats was studied. Two and four days after adrenalectomy (ADX) on either day 5 or 10 after birth, a significant decrease in the concentration of FSH was found; 4 days after ADX on either day 15 or 20, FSH concentrations had increased significantly compared with sham-operated and/or intact controls. However, in the rats adrenalectomized on day 15 or 20, the body weights were lower than in control rats. Relative uterine weights (mg/100 g body wt) in adrenalectomized rats never differed from those of control rats. A delay in the time at which vaginal opening and the first oestrus occurred was found in rats adrenalectomized at 20 or 25 days of age; however this delay was accompanied in these rats by a retardation in the gain in body weight. It is argued that the effects of ADX on both the release of gonadotrophins and the onset of puberty are primarily, and presumably exclusively, due to the effects on general bodily development (expressed in body weight). The lack of effect of ADX on uterine weight supports the hypothesis that 'oestrogen-like' products from the adrenal gland are not biologically active as oestrogens.

Insecticide chlorpyrifos and fungicide carbendazim, common food contaminants mixture, induce hepatic, renal, and splenic oxidative damage in female rats

2016 ◽  
Vol 36 (5) ◽  
pp. 483-493 ◽  
Author(s):  
AO Abolaji ◽  
IO Awogbindin ◽  
IA Adedara ◽  
EO Farombi
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Weight Gain ◽  
Oxidative Damage ◽  
Body Weight Gain ◽  
The Body ◽  
Female Rats ◽  
Exposure Group ◽  
Food Contaminants ◽  
Antioxidant Enzymes Activities

The fungicide carbendazim (CBZ) and insecticide chlorpyrifos (CPF) are currently applied together by farmers for the control of pests. Here, we investigated the impacts of 7 days oral co-exposure to 10 mg/kg body weight of CPF and 50 mg/kg body weight of CBZ on selected oxidative stress and antioxidant biomarkers in the liver, kidney, and spleen of female rats. The results showed that while the body weight gain and relative organ weights were not significantly affected after separate exposure to CPF and CBZ, there was a significant decrease in the body weight gain with concomitant increases in the relative kidney and spleen weights of rats treated with the mixture. Also, CPF and CBZ co-exposure significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine ( p < 0.05) when compared with the groups treated with CBZ or CPF alone and the control. The significant decreases in both antioxidant enzymes activities and nonenzymatic antioxidant level following individual administration of CPF and CBZ to rats were intensified in the co-exposure group ( p < 0.05). Additionally, the marked increases in the levels of oxidative stress indices in liver, kidney, and spleen of rats treated with CPF or CBZ alone were intensified in the co-exposure group ( p < 0.05). Histopathologically, co-exposure to CPF and CBZ exacerbates their individual effects on the liver, kidney, and spleen. These findings showed that co-exposure to CPF and CBZ in rats elicited more severe oxidative damage on the liver, kidney, and spleen of the rats, indicative of an additive effect compared to CPF or CBZ alone and as such, may pose a greater environmental risk to humans.

scholarly journals Histological study of the effects of aluminum chloride exposure on the brain of wistar rats female

2020 ◽  
Vol 10 (3-s) ◽  
pp. 37-42
Author(s):  
Hadjer Bekhedda ◽  
Norredine Menadi ◽  
Abbassia Demmouche ◽  
Abdelaziz Ghani ◽  
Hicham Mai
Keyword(s):  
Nervous System ◽  
Body Weight ◽  
Aluminum Chloride ◽  
Histological Study ◽  
The Body ◽  
Brain Weight ◽  
Female Rats ◽  
Aluminium Chloride ◽  
The Impact ◽  
The Brain

Introduction: Aluminum (Al) has the potential to be neurotoxic in human and animals, is present everywhere in the environment, many manufactured foods and medicines and is also added to drinking water for purification purposes and tooth paste cosmetic products They accumulate in living organisms and disrupt balances, and accumulate in the body biological systems, causing toxic effects (They may affect the nervous system, kidney, liver, respiratory or other functions). Nervous system is a vulnerable target for toxicants due to critical voltages which must be maintained in the cells and the all responses when voltages reach threshold levels. Objective This study aimed to expose the impact of aluminum chloride (AlCl3) on brain architecture. Methods: In our study, twenty healthy female rats were intraperitoneal administered of aluminum chloride (ALCL3) at 10 mg / kg body weight with consecutively for 15 day Result. The results showed a highly significant reduction in body weight (p<0.0001).  This is because aluminum has an anorectic effect contrariwise, there is no significant impact of aluminium exposure has been observed with respect to brain weight and relative brain weight respectively (p<0.912), (p<0.45). The histological study describes the alterations in the brain marked tissue necrosis and cytoplasmic vacuolations and karyopyknosis of neuronal cells of the brain. Conclusion; Aluminum is a toxic heavy metal and a ubiquitous environmental pollutant. It can alter the permeability of the blood-brain barrier and enter the brain, severely affecting the functioning of the nervous system. Keywords: Toxicity, brain, Aluminium chloride, Rats female, necrosis.

THE INTERRELATION OF THE GROWTH AND METABOLIC RESPONSES TO ANTERIOR PITUITARY GROWTH HORMONE ADMINISTRATION

1957 ◽  
Vol 35 (1) ◽  
pp. 1113-1118
Author(s):  
George H. Beaton ◽  
Hannah Z. Banky ◽  
Audrey M. Haufschild
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Amino Nitrogen ◽  
The Body ◽  
Female Rats ◽  
Male Rats ◽  
Weight Increase ◽  
Metabolic Alterations ◽  
Nitrogen Levels ◽  
Body Weight Increase

Doses of growth hormone which were minimal with respect to body weight increase were sufficient to produce significant alterations in liver alanine – glutamic transaminase and arginase activities and blood urea and amino nitrogen levels. The biochemical effects of the hormone appeared coincident with the body weight increase. Female rats showed a more pronounced response to growth hormone than did male rats. This sex difference was evident with respect to all of the metabolic alterations observed. Although it is not possible to state whether the metabolic alterations are direct effects of the hormone, they do take an integral part in bringing about the over-all biological effect.

scholarly journals Effect of different levels of hydrolysable tannin intake on the reproductive hormones and serum biochemical indices in healthy female rats

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Faiza Manzoor ◽  
Mahr Un Nisa ◽  
Hafiz Amjad Hussain ◽  
Nazir Ahmad ◽  
Huma Umbreen
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Density Lipoprotein ◽  
Nutrient Digestibility ◽  
Female Rats ◽  
Hydrolysable Tannin ◽  
Healthy Female ◽  
Serum Biochemical ◽  
Biochemical Indices ◽  
Different Levels

AbstractThe present work aimed to find out the effect of different levels of hydrolysable tannin (HT) on serum hormonal profile, biochemical indices, lipid profile, apparent digestibility of nutrients and body weight gain in healthy female rats. Forty five adult healthy female rats of 8 weeks old were randomly divided into five equal groups. Different doses of HT 0, 0.5, 1, 1.5 and 2% were administered daily to each rats group on the body weight basis for 6 weeks. The results had shown the reduction trend (p < 0.05) in the blood glucose, serum cholesterol, low density lipoprotein, testosterone, prolactin, ghrelin, total oxidative stress and serum iron levels; while an improvement (p < 0.05) was seen in serum follicle stimulating hormone, progesterone, luteinizing hormone, high density lipoprotein, IgM and total antioxidant capacity. However, no effect (p > 0.05) was noticed in serum IgG, protein, estrogen and calcium levels. A significant reduction (p < 0.05) was seen in the apparent nutrient digestibility and body weight gain. The results had shown improvement in the feed conversion ratio (p < 0.05) but non-significant decrease (p > 0.05) in the feed intake. The findings showed that HT had healthy effects on the serum biochemical indices and reproductive hormonal profile but had a negative impact on the nutrient digestibility. Thus, the study concluded that HT could be used as an herbal medicine for the treatment of leading metabolic and infertility diseases like obesity and polycystic ovarian syndrome in females.

Pengaruh Penggunaan Limbah Feses Sapi Dan Probiotik Sebagai Bahan Pakan Pelet Terhadap Keuntungan Usaha Pemeliharaan Ikan Lele Dumbo

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Fahrina Fahrina ◽  
Yusdar Zakaria ◽  
M. Aman Yaman
Keyword(s):  
Body Weight ◽  
Analysis Of Variance ◽  
The Body ◽  
Feed Consumption ◽  
Total Income ◽  
Feed Ingredient ◽  
Feed Cost ◽  
Commercial Feed ◽  
Pellet Feed ◽  
Different Levels

Penelitian tentang pengaruh penggunaan limbah feses sapi dan probiotik sebagai bahan pakan pelet terhadap keuntungan usaha pemeliharaan ikan lele dumbo, telah dilakukan di Station Riset II (dua) Ie Suum, UPT. University Farm, Aceh Besar sejak tanggal 22 Mei – 14 Agustus 2016. Tujuan penelitian untuk melihat keuntungan usaha pemeliharaan ikan lele dumbo dengan menggunakan limbah feses sapi dan probiotik  sebagai bahan pakan pelet organik. Penelitian ini menggunakan 800 bibit ikan Lele Dumbo. penelitian berlansung 90 hari. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) terdiri dari 4 perlakuan dan 4 ulangan. Perlakuan yang dilakukan adalah penggunaan pakan pelet organik (PPO) dengan level yang berbeda yaitu P0=0%, P1=10%, P2=20%, P3=30% kedalam ransum komersil. Parameter yang diamati meliputi aspek produksi (berat badan akhir dan total konsumsi ransum) dan aspek ekonomis (penerimaan, biaya tetap, biaya variabel, Income over Feed Cost, dan total income). Data parameter produksi yang diperoleh dianalisis dengan Analysis of Variance (ANOVA), jika didapatkan perbedaan yang nyata, dilanjutkan dengan Uji Jarak Berganda Duncan (Steel dan Torrie, 1993). Data  parameter ekonomis dianalisis dengan B/C dan R/C ratio (Sjahrial, 2008). Hasil penelitian memperlihatkan bahwa penggunaan ransum komersil dengan pakan pelet organik pada level yang berbeda selama pemeliharan berpengaruh sangat nyata (P0.01) terhadap berat badan dan konsumsi ransum ikan lele dumbo. Penggunaan ransum komersil dengan pakan pelet organik selama pemeliharaan menurunkan biaya ransum dan menaikkan Income Over Feed Cost (IOFC)  dan total income pemeliharaan ikan Lele Dumbo. Pemberian pakan komersil 90% + PPO 10% layak dan menguntungkan dalam pemeliharaan ikan Lele Dumbo. Effect Of The Use Of  Waste Cow Feces And Probiotics As Pellet Feed Ingredient To The Profit Of Maintenance Business Of CatfishResearch on the effect of the use of cow feces waste and probiotics as pellet feed ingredient to the profit of maintenance business of catfish has been conducted in Research Station II (two) Ie Seum, UPT. University Farm, Aceh Besar from May 22, to August 14, 2016. The purpose of this research is to see the profit of  catfish maintenance business by using cow feces waste and probiotics as organic food pellet feed. This research uses 800 catfish seedlings , the studywas done for 90 days. This study used a complete randomized design (RAL) consisting of 4 treatments and 4 replications. Treatment was the used of organic feed pellets (PPO) with different levels as P0 = 0%, P1 = 10%, P2 = 20%, P3 = 30% into commercial ration. The parameters observed production of aspects (final body weight and total  feed consumption) and economic aspects  (revenue, cost, Income over Feed Cost, and total income). The former was analyzed by Analysis of Variance (ANOVA),  if significantly different results were detected, then continued by Duncan's Multiple Range Test (Steel and Torrie, 1993), while the latter was analysis by B/C and R/C ratio (Sjahrial, 2008).  The results of study showed that the use of commercial feed with an organic pellet feed at different levels during maintenance was highly significant (P 0.01) in the body weight and feed intake of catfish. The use of commercial feed with an organic pellet feed for lowering maintenance costs and increase the ration Income Over Feed Cost (IOFC), and total income maintenance catfish. Feeding commercial 90% + PPO 10% viable and profitable in the maintenance catfish.

Effects of intestinal bypass surgery on appetite, food intake, and body weight in obese and lean rats.

1978 ◽  
Vol 234 (4) ◽  
pp. E389 ◽  
Author(s):  
A Sclafani ◽  
H S Koopmans ◽  
J R Vasselli ◽  
M Reichman
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Bypass Surgery ◽  
Sucrose Solution ◽  
Caloric Intake ◽  
Jejunoileal Bypass ◽  
The Body ◽  
Female Rats ◽  
Intestinal Bypass ◽  
Clinical Observations

Jejunoileal bypass surgery or sham surgery was performed in female rats made obese with ventromedial hypothalamic (VMH) knife cuts, and in lean control rats. After bypass surgery, the VMH rats underate and lost weight until they reached the body weight of the control sham rats, and they then maintained their weight at control levels. Bypass surgery in lean rats produced much smaller reductions in food intake and body weight. Both bypass groups initially consumed less of a sucrose solution and milk diet during 1 h/day tests, but their intakes returned to near normal levels during the second postoperative month. Reconnection of the intestinal tract in the VMH-bypass rats led to renewed hyperphagia and return to obese body weights. A second experiment revealed that bypass surgery reduces food intake and body weight in genetically obese (fatty) rats, but this effect is not as pronounced as that displayed by VMH rats. These results confirm recent clinical observations that reduced appetite and caloric intake are the major causes of the weight loss produced by intestinal bypass surgery.

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